Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles

Advances and challenges in stroke rehabilitation

(2020) Cathy M Stinear et al.   LANCET NEUROLOGY

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial

(2020) Hugues Chabriat et al.   LANCET NEUROLOGY

Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery

(2020) Ping Sun et al.   CIRCULATION RESEARCH

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro

(2020) Eyad Naser et al.   JOURNAL OF LIPID RESEARCH

Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial

(2020) Erik Lundström et al.   LANCET NEUROLOGY

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Sphingolipidomics Investigation of the Temporal Dynamics after Ischemic Brain Injury

(2019) Hsi-Chun Chao et al.   JOURNAL OF PROTEOME RESEARCH

Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

(2019) Simon F. Merz et al.   Nature Communications

High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation

(2018) Fengyan Jin et al.   ANGIOGENESIS

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

(2018) Claudia Verderio et al.   JOURNAL OF LIPID RESEARCH

Comparison of In-Solution, FASP, and S-Trap Based Digestion Methods for Bottom-Up Proteomic Studies

(2018) Katelyn R. Ludwig et al.   JOURNAL OF PROTEOME RESEARCH

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

(2018) Raul G. Nogueira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

(2018) Anne Gulbins et al.   MOLECULAR PSYCHIATRY

Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging

(2018) Takatsugu ABE et al.   NEUROLOGIA MEDICO-CHIRURGICA

Postacute Delivery of GABA A α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling

(2018) Ya-chao Wang et al.   STROKE

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

(2018) Martin Dennis et al.   LANCET

Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

(2018) Min Hee Park et al.   NEURON

New Directions in Treatments Targeting Stroke Recovery

(2018) David J. Lin et al.   STROKE

3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy

(2017) Erlen Lugo-Hernandez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Restoring brain function after stroke — bridging the gap between animals and humans

(2017) Nick S. Ward   Nature Reviews Neurology

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia

(2017) Leonardo Ermini et al.   Scientific Reports

Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide

(2016) Anne Gulbins et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

(2016) Mette M. B. Nielsen et al.   Scientific Reports

The role of sphingolipids in endothelial barrier function

(2015) Peter L. Jernigan et al.   BIOLOGICAL CHEMISTRY

Promoting brain remodeling to aid in stroke recovery

(2015) Zheng Gang Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine

(2015) R. Brunkhorst et al.   NEURAL PLASTICITY

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

The ceramide system as a novel antidepressant target

(2014) Johannes Kornhuber et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking

(2013) Fengyan Jin et al.   ANGIOGENESIS

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis

(2013) Carlos Salomon et al.   PLoS One

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

(2011) Viktoriya Sokolova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics

(2011) Julia Maria Burkhart et al.   Journal of Proteomics

Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial

(2011) François Chollet et al.   LANCET NEUROLOGY

Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions

(2011) Josephine Herz et al.   NEUROBIOLOGY OF DISEASE

Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity

(2010) Raluca Reitmeir et al.   BRAIN

Subventricular Zone-Derived Neural Progenitor Cells Migrate Along a Blood Vessel Scaffold Toward the Post-Stroke Striatum

(2010) Takuro Kojima et al.   STEM CELLS

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

(2009) Tae Kyeong Shin et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect

(2008) Chae-Moon Lim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke

(2008) Wen-Lei Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

(2008) X. Deng et al.   SCIENCE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Nortriptyline Protects Mitochondria and Reduces Cerebral Ischemia/Hypoxia Injury

(2008) Wen-hua Zhang et al.   STROKE

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY