Journal
MOLECULAR MEDICINE
Volume 22, Issue -, Pages 192-201Publisher
FEINSTEIN INST MED RES
DOI: 10.2119/molmed.2015.00026
Keywords
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Funding
- Natural Science Foundation of China [81200148, 81270281, 81470371, 81000055]
- Jiangsu Provincial Special Program of Medical Science [BL2012014]
- State Key Laboratory of Pharmaceutical Biotechnology [KF-GN-200901]
- Peak of Six - Personnel in Jiangsu Province [2013-WSN-008]
- Funds for Distinguished Young Scientists in Nanjing [JQX13006]
- Key Program of the Science Foundation in Nanjing [ZKX13023]
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Cardiac hypertrophy can be broadly classified as either physiological or pathological. Physiological stimuli such as exercise cause adaptive cardiac hypertrophy and normal heart function. Pathological stimuli including hypertension and aortic valvular stenosis cause maladaptive cardiac remodeling and ultimately heart failure. Syndecan-4 (synd4) is a transmembrane - proteoglycan identified as being involved in cardiac adaptation after injury, but whether it takes part in physiological cardiac hypertrophy is unclear. We observed upregulation of synd4 in exercise-induced hypertrophic myocardium. To evaluate the role of synd4 in the - physiological form of cardiac hypertrophy, mice lacking synd4 (synd4(-/-)) were exercised by swimming for 4 wks. Ultrasonic cardiogram (UCG) and histological analysis revealed that swimming induced the hypertrophic phenotype but was blunted in synd4-/- compared with wildtype (WT) mice. The swimming-induced activation of Akt, a key molecule in physiological - hypertrophy was also more decreased than in WT controls. In cultured cardiomyocytes, synd4 overexpression could induce cell enlargement, protein synthesis and distinct physiological molecular alternation. Akt activation also was observed in synd4-overexpressed cardiomyocytes. Furthermore, inhibition of protein kinase C (PKC) prevented the synd4-induced hypertrophic phenotype and Akt phosphorylation. This study identified an essential role of synd4 in mediation of physiological cardiac hypertrophy.
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