Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis

Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

(2022) Jie Tong et al.   Acta Pharmaceutica Sinica B

Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

(2022) Xingchun Wang et al.   Cell Death Discovery

Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability

(2022) Chen Chi et al.   EUROPEAN HEART JOURNAL

MAFLD: a holistic view to redefining fatty liver disease

(2021) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

A systematic review of animal models of NAFLD finds high fat, high fructose diets most closely resemble human NAFLD

(2021) Yu Ri Im et al.   HEPATOLOGY

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

(2021) SangJoon Lee et al.   NATURE

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

(2021) Wulf Tonnus et al.   Nature Communications

Hepcidin Downregulation Correlates With Disease Aggressiveness And Immune Infiltration in Liver Cancers

(2021) Jinhu Wang et al.   Frontiers in Oncology

Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4

(2021) Zixin Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1

(2021) Shyamalagauri Jadhav et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel therapeutic targets for cholestatic and fatty liver disease

(2021) Michael Trauner et al.   GUT

Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death

(2021) Omkar Zilka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of Nonalcoholic Fatty Liver Disease

(2020) James M. Paik et al.   HEPATOLOGY

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Animal Models for Liver Disease - A Practical Approach for Translational Research

(2020) Yulia A. Nevzorova et al.   JOURNAL OF HEPATOLOGY

Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity

(2020) Xiaoya Li et al.   LIVER INTERNATIONAL

From NAFLD to MAFLD: Implications of a premature change in terminology

(2020) Zobair M Younossi et al.   HEPATOLOGY

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Parimal Samir et al.   Frontiers in Cellular and Infection Microbiology

The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy

(2020) Shalini S. Rao et al.   JOURNAL OF ALZHEIMERS DISEASE

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

(2020) Xingyan Li et al.   Nature Communications

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

Melatonin safeguards against fatty liver by antagonizing TRAFs‐mediated ASK1 deubiquitination and stabilization in a β‐arrestin‐1 dependent manner

(2019) Dong‐Jie Li et al.   JOURNAL OF PINEAL RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer

(2018) Sun-Hye Jeong et al.   JOURNAL OF CLINICAL INVESTIGATION

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Nicotinic acetylcholine receptor α7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease

(2018) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Deferoxamine ameliorates hepatosteatosis via several mechanisms inob/obmice

(2016) Han Xue et al.   Annals of the New York Academy of Sciences

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Physiological and Pharmacological Control of BAK, BAX, and Beyond

(2016) Mark P.A. Luna-Vargas et al.   TRENDS IN CELL BIOLOGY

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

(2016) Tanja Krainz et al.   ACS Central Science

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Aging promotes the development of diet-induced murine steatohepatitis but not steatosis

(2012) Luis Fontana et al.   HEPATOLOGY

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS