Retigabine holds KV7 channels open and stabilizes the resting potential

The Sensorless Pore Module of Voltage-gated K+Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine

(2015) Ruhma Syeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bimodal regulation of an Elk subfamily K+channel by phosphatidylinositol 4,5-bisphosphate

(2015) Xiaofan Li et al.   JOURNAL OF GENERAL PHYSIOLOGY

Early-Onset Epileptic Encephalopathy Caused by Gain-of-Function Mutations in the Voltage Sensor of Kv7.2 and Kv7.3 Potassium Channel Subunits

(2015) F. Miceli et al.   JOURNAL OF NEUROSCIENCE

A recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of Kv7 channels

(2015) Affef Abidi et al.   NEUROBIOLOGY OF DISEASE

Novel Genes of Early-Onset Epileptic Encephalopathies: From Genotype to Phenotypes

(2015) Mario Mastrangelo   PEDIATRIC NEUROLOGY

Atomic basis for therapeutic activation of neuronal potassium channels

(2015) Robin Y. Kim et al.   Nature Communications

Hv1 Proton Channel Opening Is Preceded by a Voltage-independent Transition

(2014) Carlos A. Villalba-Galea   BIOPHYSICAL JOURNAL

A novelKCNQ3mutation in familial epilepsy with focal seizures and intellectual disability

(2014) Francesco Miceli et al.   EPILEPSIA

Conditional Deletions of Epilepsy-Associated KCNQ2 and KCNQ3 Channels from Cerebral Cortex Cause Differential Effects on Neuronal Excitability

(2014) H. Soh et al.   JOURNAL OF NEUROSCIENCE

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

S3-S4 Linker Length Modulates the Relaxed State of a Voltage-Gated Potassium Channel

(2013) Michael F. Priest et al.   BIOPHYSICAL JOURNAL

Sensing charges of theCiona intestinalisvoltage-sensing phosphatase

(2013) Carlos A. Villalba-Galea et al.   JOURNAL OF GENERAL PHYSIOLOGY

Investigations into the Mechanism of Action of the New Anticonvulsant Retigabine - Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels

(2012) Chris Rundfeldt et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

(2012) Martin J. Gunthorpe et al.   EPILEPSIA

Retigabine/Ezogabine, a KCNQ/KV7 channel opener: pharmacological and clinical data

(2012) Gökce Orhan et al.   EXPERT OPINION ON PHARMACOTHERAPY

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

(2012) Ernesto Vargas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular mechanism for depolarization-induced modulation of Kv channel closure

(2012) Alain J. Labro et al.   JOURNAL OF GENERAL PHYSIOLOGY

Infrared light excites cells by changing their electrical capacitance

(2012) Mikhail G. Shapiro et al.   Nature Communications

Probability Fluxes and Transition Paths in a Markovian Model Describing Complex Subunit Cooperativity in HCN2 Channels

(2012) Klaus Benndorf et al.   PLoS Computational Biology

Voltage-Controlled Enzymes: The New JanusBifrons

(2012) Carlos A. Villalba-Galea   Frontiers in Pharmacology

Properties of Deactivation Gating Currents in Shaker Channels

(2011) Jérôme J. Lacroix et al.   BIOPHYSICAL JOURNAL

M channel enhancers and physiological M channel block

(2011) John E. Linley et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Voltage-Sensing Domain of Kv7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants

(2011) Francesco Miceli et al.   Frontiers in Pharmacology

KV7 channelopathies

(2010) Snezana Maljevic et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effect of Voltage Sensitive Fluorescent Proteins on Neuronal Excitability

(2009) Walther Akemann et al.   BIOPHYSICAL JOURNAL

Charge Movement of a Voltage-Sensitive Fluorescent Protein

(2009) Carlos A. Villalba-Galea et al.   BIOPHYSICAL JOURNAL

Neural KCNQ (Kv7) channels

(2009) David A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

Refinement of the Binding Site and Mode of Action of the Anticonvulsant Retigabine on KCNQ K+ Channels

(2008) W. Lange et al.   MOLECULAR PHARMACOLOGY

How membrane proteins sense voltage

(2008) Francisco Bezanilla   NATURE REVIEWS MOLECULAR CELL BIOLOGY

S4-based voltage sensors have three major conformations

(2008) C. A. Villalba-Galea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs

(2007) F MICELI et al.   CURRENT OPINION IN PHARMACOLOGY

Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy

(2007) Thomas V. Wuttke et al.   JOURNAL OF PHYSIOLOGY-LONDON