Inflammation-induced transgene expression in genetically engineered equine mesenchymal stem cells

scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy

(2015) L R Goodrich et al.   GENE THERAPY

Pretreatment of mesenchymal stem cells with angiotensin II enhances paracrine effects, angiogenesis, gap junction formation and therapeutic efficacy for myocardial infarction

(2015) Chao Liu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Genetically engineered mesenchymal stromal cells producing TNFα have tumour suppressing effect on human melanoma xenograft

(2015) Silvia Tyciakova et al.   JOURNAL OF GENE MEDICINE

Engineering mesenchymal stem cells for regenerative medicine and drug delivery

(2015) Ji Sun Park et al.   METHODS

Mesenchymal Stromal Cell Therapy in Hematology: From Laboratory to Clinic and Back Again

(2015) Ann De Becker et al.   STEM CELLS AND DEVELOPMENT

Use of mesenchymal stem cells to treat liver fibrosis: Current situation and future prospects

(2015) Silvia Berardis et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mesenchymal Stem Cell Implantation in Osteoarthritic Knees

(2014) Yong Sang Kim et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis

(2014) Eline A Vermeij et al.   ANNALS OF THE RHEUMATIC DISEASES

Tissue-engineered cartilage with inducible and tunable immunomodulatory properties

(2014) Katherine A. Glass et al.   BIOMATERIALS

Optimization of a nonviral transfection system to evaluate Cox-2 controlled interleukin-4 expression for osteoarthritis gene therapyin vitro

(2014) Annemarie Lang et al.   JOURNAL OF GENE MEDICINE

Autologous protein solution prepared from the blood of osteoarthritic patients contains an enhanced profile of anti-inflammatory cytokines and anabolic growth factors

(2014) Krista O'Shaughnessey et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Characterization of Constitutive Promoters for piggyBac Transposon-Mediated Stable Transgene Expression in Mesenchymal Stem Cells (MSCs)

(2014) Sheng Wen et al.   PLoS One

Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

(2014) Anika I Tsuchida et al.   ARTHRITIS RESEARCH & THERAPY

Mesenchymal Stem Cells in Cartilage Regeneration

(2014) Vuk Savkovic et al.   Current Stem Cell Research & Therapy

Mechanisms of Immune Modulation by Mesenchymal Stromal Cells and Clinical Translation

(2013) J. Stagg et al.   CURRENT MOLECULAR MEDICINE

Inflammatory Cytokines Induce a Unique Mineralizing Phenotype in Mesenchymal Stem Cells Derived from Human Bone Marrow

(2013) Elisabeth Ferreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autologous solution protects bovine cartilage explants from IL-1α- and TNFα-induced cartilage degradation

(2013) Andrea Matuska et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Advances in Regenerative Orthopedics

(2013) Christopher H. Evans   MAYO CLINIC PROCEEDINGS

Synovial joint fluid cytokine levels in hip disease

(2013) H. Abe et al.   RHEUMATOLOGY

Arthritis gene therapy and its tortuous path into the clinic

(2013) Christopher H. Evans et al.   Translational Research

Inflammatory effects of autologous, genetically modified autologous, allogeneic, and xenogeneic mesenchymal stem cells after intra-articular injection in horses

(2013) J. H. Pig et al.   VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

(2013) Laurie R Goodrich et al.   Molecular Therapy-Nucleic Acids

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

(2012) R S Watson et al.   GENE THERAPY

Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells

(2012) Sebastian Elsler et al.   JOURNAL OF GENE MEDICINE

Ku80 attentuates cytotoxicity induced by green fluorescent protein transduction independently of non-homologous end joining

(2012) Manabu Koike et al.   FEBS Open Bio

Clinical potential and challenges of using genetically modified cells for articular cartilage repair

(2011) Henning Madry et al.   CROATIAN MEDICAL JOURNAL

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Autologous conditioned serum: The comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood

(2011) T. H. HRAHA et al.   EQUINE VETERINARY JOURNAL

Metabolic Activities and Chondrogenic Differentiation of Human Mesenchymal Stem Cells Following Recombinant Adeno-Associated Virus–Mediated Gene Transfer and Overexpression of Fibroblast Growth Factor 2

(2011) Magali Cucchiarini et al.   TISSUE ENGINEERING PART A

Catabolic Factors and Osteoarthritis-Conditioned Medium Inhibit Chondrogenesis of Human Mesenchymal Stem Cells

(2011) Genoveva T.H. Heldens et al.   TISSUE ENGINEERING PART A

Genetically modified cells in regenerative medicine and tissue engineering☆

(2010) Dima Sheyn et al.   ADVANCED DRUG DELIVERY REVIEWS

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Anticytokine Therapy for Osteoarthritis

(2010) Charles J. Malemud   DRUGS & AGING

Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi

(2010) J. L. KAMM et al.   EQUINE VETERINARY JOURNAL

Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter

(2010) C E Badr et al.   GENE THERAPY

Shifting HIFs in osteoarthritis

(2010) Matthew Husa et al.   NATURE MEDICINE

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Interleukin-1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF-κB-dependent pathways

(2009) N. Wehling et al.   ARTHRITIS AND RHEUMATISM

Alterations of the CD4+, CD8+ T Cell Subsets, Interleukins-1β, IL-10, IL-17, Tumor Necrosis Factor-α and Soluble Intercellular Adhesion Molecule-1 in Rheumatoid Arthritis and Osteoarthritis: Preliminary Observations

(2009) Mahmoud R. Hussein et al.   PATHOLOGY & ONCOLOGY RESEARCH

Application of inflammation‐responsive promoter for an in vitro arthritis model

(2008) P. Sivaramakrishna Rachakonda et al.   ARTHRITIS AND RHEUMATISM

Lentiviral-Transduced Human Mesenchymal Stem Cells Persistently Express Therapeutic Levels of Enzyme in a Xenotransplantation Model of Human Disease

(2008) Todd E. Meyerrose et al.   STEM CELLS