scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy

OARSI guidelines for the non-surgical management of knee osteoarthritis

(2014) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial

(2014) Muneaki Ishijima et al.   ARTHRITIS RESEARCH & THERAPY

Arthritis gene therapy and its tortuous path into the clinic

(2013) Christopher H. Evans et al.   Translational Research

Multiple Recombinant Adeno-Associated Viral Vector Serotypes Display Persistent In Vivo Gene Expression in Vector-Transduced Rat Stifle Joints

(2013) Jeffrey B. Mason et al.   Human Gene Therapy Methods

The horse as a model of naturally occurring osteoarthritis

(2013) C. W. McIlwraith et al.   Bone & Joint Research

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

(2013) Laurie R Goodrich et al.   Molecular Therapy-Nucleic Acids

Influence of serotype, cell type, tissue composition, and time after inoculation on gene expression in recombinant adeno-associated viral vector–transduced equine joint tissues

(2012) Jeffrey B. Mason et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

(2012) R S Watson et al.   GENE THERAPY

Single Amino Acid Modification of Adeno-Associated Virus Capsid Changes Transduction and Humoral Immune Profiles

(2012) C. Li et al.   JOURNAL OF VIROLOGY

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254)

(2012) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates

(2011) Steven J Gray et al.   MOLECULAR THERAPY

Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)

(2011) Jonathan B Catterall et al.   ARTHRITIS RESEARCH & THERAPY

Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: Report of forty-six patients from an international multicenter series

(2010) Peter A. Nigrovic et al.   ARTHRITIS AND RHEUMATISM

Efficacy and Safety of Retreatment in Patients with Rheumatoid Arthritis with Previous Inadequate Response to Tumor Necrosis Factor Inhibitors: Results from the SUNRISE Trial

(2010) P. J. MEASE et al.   JOURNAL OF RHEUMATOLOGY

Getting arthritis gene therapy into the clinic

(2010) Christopher H. Evans et al.   Nature Reviews Rheumatology

Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection

(2010) Marijn Rutgers et al.   ARTHRITIS RESEARCH & THERAPY

Evaluation of polysulfated glycosaminoglycan or sodium hyaluronan administered intra-articularly for treatment of horses with experimentally induced osteoarthritis

(2009) David D. Frisbie et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Ex Vivo Serotype-Specific Transduction of Equine Joint Tissue by Self-Complementary Adeno-Associated Viral Vectors

(2009) L.R. Goodrich et al.   HUMAN GENE THERAPY

Clinical Responses to Gene Therapy in Joints of Two Subjects with Rheumatoid Arthritis

(2009) Peter Wehling et al.   HUMAN GENE THERAPY

Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus

(2009) Jesse D. Kay et al.   JOURNAL OF GENE MEDICINE

Safety, Tolerability, and Clinical Outcomes after Intraarticular Injection of a Recombinant Adeno-associated Vector Containing a Tumor Necrosis Factor Antagonist Gene: Results of a Phase 1/2 Study

(2009) P. J. MEASE et al.   JOURNAL OF RHEUMATOLOGY

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY

Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis

(2008) A.W.A. Baltzer et al.   OSTEOARTHRITIS AND CARTILAGE

Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial

(2007) K.G. Auw Yang et al.   OSTEOARTHRITIS AND CARTILAGE