Host–virus interactions in hepatitis B and hepatitis C infection

Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis

(2016) Yuchen Xia et al.   GASTROENTEROLOGY

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly

(2015) Hiromichi Dansako et al.   FEBS Journal

Natural killer cell phenotype modulation and natural killer/T-cell interplay in nucleos(t)ide analogue-treated hepatitis e antigen-negative patients with chronic hepatitis B

(2015) Carolina Boni et al.   HEPATOLOGY

Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B

(2015) Sachiyo Yoshio et al.   HEPATOLOGY

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

A novel dendritic-cell-targeting DNA vaccine for hepatitis B induces T cell and humoral immune responses and potentiates the antivirus activity in HBV transgenic mice

(2015) Debin Yu et al.   IMMUNOLOGY LETTERS

A thymine–adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus

(2015) Satoshi Hiramine et al.   JOURNAL OF GASTROENTEROLOGY

Early inhibition of hepatocyte innate responses by hepatitis B virus

(2015) Souphalone Luangsay et al.   JOURNAL OF HEPATOLOGY

Association of serum IFN-λ3 with inflammatory and fibrosis markers in patients with chronic hepatitis C virus infection

(2014) Yoshihiko Aoki et al.   JOURNAL OF GASTROENTEROLOGY

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

(2014) Yinghui Liu et al.   JOURNAL OF VIROLOGY

Hepatitis B virus infection

(2014) Christian Trépo et al.   LANCET

HBV and the immune response

(2014) Carlo Ferrari   LIVER INTERNATIONAL

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

(2014) Jia Liu et al.   PLoS Pathogens

The Role of Natural Killer Cells and CD8+ T Cells in Hepatitis B Virus Infection

(2014) Anita Schuch et al.   Frontiers in Immunology

Genome-Wide Association Study of Spontaneous Resolution of Hepatitis C Virus Infection: Data From Multiple Cohorts

(2013) Priya Duggal et al.   ANNALS OF INTERNAL MEDICINE

T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

(2013) Karin Krebs et al.   GASTROENTEROLOGY

Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection

(2013) Shujuan Lv et al.   HEPATOLOGY

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver

(2013) Stefan Wieland et al.   HEPATOLOGY

Natural killer cells: multifaceted players with key roles in hepatitis C immunity

(2013) Lucy Golden-Mason et al.   IMMUNOLOGICAL REVIEWS

Mobilizing monocytes to cross-present circulating viral antigen in chronic infection

(2013) Adam J. Gehring et al.   JOURNAL OF CLINICAL INVESTIGATION

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus–induced microRNAs

(2013) Adelle P McFarland et al.   NATURE IMMUNOLOGY

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

(2013) Li-Rung Huang et al.   NATURE IMMUNOLOGY

Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection

(2013) Su-Hyung Park et al.   NATURE MEDICINE

Galectin-9 and IL-21 Mediate Cross-regulation between Th17 and Treg Cells during Acute Hepatitis C

(2013) Hassen Kared et al.   PLoS Pathogens

NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection

(2013) Mala K. Maini et al.   Frontiers in Immunology

Targeted delivery of interferon-α to hepatitis B virus-infected cells using T-cell receptor-like antibodies

(2012) Changhua Ji et al.   HEPATOLOGY

Plasmacytoid dendritic cells induce efficient stimulation of antiviral immunity in the context of chronic hepatitis B virus infection

(2012) Jeremie Martinet et al.   HEPATOLOGY

IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection

(2012) Heiyoung Park et al.   HEPATOLOGY

Human blood dendritic cell antigen 3 (BDCA3)+dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus

(2012) Sachiyo Yoshio et al.   HEPATOLOGY

Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion

(2012) Dimitra Peppa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

IFN-λs

(2011) Sergei V Kotenko   CURRENT OPINION IN IMMUNOLOGY

Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-α in Chimeric Mice

(2011) Marc Lütgehetmann et al.   GASTROENTEROLOGY

How chronic viral infections impact on antigen-specific T-cell responses

(2010) Helge Frebel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C

(2010) Thomas J. Urban et al.   HEPATOLOGY

Functional changes, increased apoptosis, and diminished nuclear factor–κB activity of myeloid dendritic cells during chronic hepatitis C infection

(2010) Li Zhao et al.   HUMAN IMMUNOLOGY

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKK  and DDX3

(2010) S. Yu et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection

(2010) José-Ignacio Riezu-Boj et al.   JOURNAL OF HEPATOLOGY

Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B

(2010) Eric T.T.L. Tjwa et al.   JOURNAL OF HEPATOLOGY

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

(2010) C. Wei et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Inhibition Is Connected to Exhaustion of CD8+ T Cell Polyfunctionality during Chronic Hepatitis C Virus Infection

(2010) I. G. Rodrigue-Gervais et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection

(2010) Dimitra Peppa et al.   PLoS Pathogens

Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections

(2009) Barbara Oliviero et al.   GASTROENTEROLOGY

Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

(2009) P Fisicaro et al.   GUT

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

(2009) Barbara Rehermann   JOURNAL OF CLINICAL INVESTIGATION

Differential Effects of Hepatitis C Virus JFH1 on Human Myeloid and Plasmacytoid Dendritic Cells

(2009) H. Liang et al.   JOURNAL OF VIROLOGY

Patients with chronic hepatitis B infection display deficiency of plasmacytoid dendritic cells with reduced expression of TLR9

(2009) Qing Xie et al.   MICROBES AND INFECTION

HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells

(2009) Yongfen Xu et al.   MOLECULAR IMMUNOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Host genetic determinants of spontaneous hepatitis C clearance

(2009) Andri Rauch et al.   PHARMACOGENOMICS

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Natural killer cell function is intact after direct exposure to infectious hepatitis C virions

(2008) Joo Chun Yoon et al.   HEPATOLOGY

Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells

(2008) Svetlana Marukian et al.   HEPATOLOGY

Hepatitis C virus–infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells

(2008) Takashi Ebihara et al.   HEPATOLOGY

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

(2008) Jun Wu et al.   HEPATOLOGY

Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus

(2008) Marjoleine L. Op den Brouw et al.   IMMUNOLOGY

Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure

(2008) Zheng Zhang et al.   JOURNAL OF HEPATOLOGY

Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived Cells

(2008) H. Guo et al.   JOURNAL OF VIROLOGY

Genetic interactions of KIR and G1M immunoglobulin allotypes differ in obese from non-obese individuals with type 2 diabetes

(2008) Viviana Romero et al.   MOLECULAR IMMUNOLOGY