Review
Gastroenterology & Hepatology
Yiftach Barash, Eyal Klang, Noam Tau, Shomron Ben-Horin, Hussein Mahajna, Asaf Levartovsky, Naila Arebi, Shelly Soffer, Uri Kopylov
Summary: The study found a steady increase in the number of publications related to inflammatory bowel disease over the past 25 years. While the United States leads in total publication count, Denmark, Sweden, and Israel stand out in terms of per capita publications. Medical therapeutics is the most popular topic, with a rising focus on imaging and monitoring research.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Kunio Asonuma, Keiji Ozeki, Hajime Yamazaki, Shinji Okabayashi, Soh Okano, Ryo Ozaki, Nobuaki Nishimata, Hiroki Kiyohara, Naoki Ichinari, Taku Kobayashi, Masahiro Yamada, Mao Matsubayashi, Yoko Yokoyama, Shoko Arimitsu, Junji Umeno, Yoshinori Munetomo, Akira Andoh, Shinichiro Shinzaki, IBD Terakoya Grp
Summary: The use of immunomodulators after discontinuing anti-TNF-alpha antibody treatment was not significantly associated with relapse in patients with UC. Careful patient follow-up is necessary when discontinuing due to side effects or in younger patients at the time of discontinuation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Abel Botelho Quaresma, Fernanda da Silva Barbosa Barauna, Fabio Vieira Teixeira, Rogerio Saad-Hossne, Paulo Gustavo Kotze
Summary: Most studies have not shown increased complication rates after abdominal surgical procedures in UC patients with preoperative exposure to biologics. Further prospective studies are needed to better establish the impact of preoperative biologics on surgical complications in UC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jongwook Yu, Soo Jung Park, Hyung Wook Kim, Yun Jeong Lim, Jihye Park, Jae Myung Cha, Byong Duk Ye, Tae Oh Kim, Hyun-Soo Kim, Hyun Seok Lee, Su Young Jung, Youngdoe Kim, Chang Hwan Choi
Summary: The study demonstrated that golimumab was effective and safe as an induction and maintenance treatment for Korean patients with moderate-to-severe UC. Clinical response and remission rates increased over time, with a mucosal healing rate of 65.8%.
Article
Gastroenterology & Hepatology
Judy Splawski, Atiye Nur Aktay, Sharon Perry, Virginia Baez-Socorro, Sarah DeLozier, Thomas J. Sferra, Jonathan Moses
Summary: This study compares the association of eosinophilic esophagitis (EoE) with ulcerative colitis (UC) and Crohn's disease (CD), finding that a higher percentage of UC patients had EoE compared to CD patients. EoE was more likely to be present at the initial diagnosis of UC than CD. Additionally, EoE was more likely to occur after diagnosis and treatment of CD with anti-TNF, when CD activity was mild or in remission.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Amy Yu, Sonia Friedman, Ashwin N. Ananthakrishnan
Summary: This study analyzed patients with pregnancy-onset IBD, and found that they were more likely to develop ulcerative colitis and had a higher risk of disease-related hospitalizations.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hiroki Tanaka, Fuminao Takeshima, Shingo Kato, Takehiro Torisu, Yuki Ohta, Kenji Watanabe, Shiro Nakamura, Naoki Yoshimura, Taku Kobayashi, Akiko Shiotani, Fumihito Hirai, Sakiko Hiraoka, Mamoru Watanabe, Minoru Matsuura, Shohei Nishimoto, Shinta Mizuno, Hideki Iijima, Tetsuo Takehara, Tetsuji Naka, Takanori Kanai, Takayuki Matsumoto
Summary: This study evaluated the usefulness of serum leucin-rich alpha-2 glycoprotein (LRG) levels in monitoring disease activity in inflammatory bowel disease (IBD) during adalimumab treatment. The results showed that serum LRG levels correlated with endoscopic activity in both Crohn's disease (CD) and ulcerative colitis (UC), and had better correlation compared to C-reactive protein (CRP) and fecal calprotectin (fCal). Serum LRG was found to be a useful biomarker for assessing endoscopic activity in IBD patients.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Michelle T. Lee, Dhruv Mahtta, Liang Chen, Aliza Hussain, Mahmoud Al Rifai, Preetika Sinh, Umair Khalid, Khurram Nasir, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani
Summary: This study found an association between inflammatory bowel disease and extremely premature atherosclerotic cardiovascular disease, especially in patients under 40 years of age. As patients age, this risk is attenuated by traditional cardiometabolic factors such as obesity, hypertension, diabetes, smoking, and dyslipidemia.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Helene Hermand, Jeremie H. Lefevre, Conor Shields, Najim Chafai, Clotilde Debove, Laurent Beaugerie, Magali Svrcek, Yann Parc
Summary: The study found that a small proportion of patients undergoing subtotal colectomy may have their diagnosis changed from ulcerative colitis to Crohn's disease postoperatively, with patients with a disease duration of less than 10 years and an initial diagnosis of IBDU being at higher risk for this diagnostic change.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Pharmacology & Pharmacy
Hassan Maleki, Maryam Doostan, Mohammad Hosein Farzaei, Parisa Seifi, Shahram Miraghaee, Mahtab Doostan
Summary: This study aimed to formulate a colon-specific delivery system for A. wilhelmsii extract using chitosan nanoparticles and Eudragit S100. The prepared nanoparticles showed spherical shape, suitable size, and high encapsulation efficiency. They exhibited a pH-sensitive release pattern and effectively mitigated UC-related inflammation and colonic lesions.
Article
Gastroenterology & Hepatology
Hillary Moore, Joshua Wechsler, Carrie Frost, Elizabeth Whiteside, Robert Baldassano, Jonathan Markowitz, Amanda B. Muir
Summary: This study investigated the pediatric population with both EoE and IBD, revealing a notable trend of co-occurrence of these two diseases in the same patient. Patients with both diseases were more likely to have IgE-mediated food allergy, and treatment with anti-TNFs can reduce the risk of developing EoE.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Jeongseok Kim, Hyuk Yoon, Nayoung Kim, Kang-Moon Lee, Sung-Ae Jung, Chang Hwan Choi, Eun Soo Kim, Yunho Jung, Chang Soo Eun, Tae Oh Kim, Sang-Bum Kang, You Sun Kim, Geom-Seog Seo, Chang Kyun Lee, Jong Pil Im, Soo Jung Park, Dong Il Park, Byong Duk Ye
Summary: The study demonstrated the effectiveness and safety of VDZ induction therapy among Korean patients with CD or UC for whom anti-tumor necrosis factor therapy failed. Early clinical response was associated with clinical remission after VDZ induction therapy.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Rachel Levy, Manar Matar, Maya Zvuloni, Raanan Shamir, Amit Assa
Summary: TC response to adjustment of anti-TNFa treatment can be predicted for adalimumab but not for infliximab. Decreasing interval for adalimumab results in increased TC, while increasing interval for adalimumab and dose increase for infliximab both lead to decreased TC.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Immunology
Xia Luo, Xiaojing Wang, Shaowei Huang, Bo Xu, Shuang Luo, Yanyang Li, Qing Wang, Yanping Chen, Xiangliang Deng, Lingyun Liu, Lian Zhou
Summary: The study reveals that an increase in abundance and infiltration of Gram-positive bacteria in colon tissues of ulcerative colitis mice. Paeoniflorin can significantly alleviate symptoms of experimental colitis, reduce Gram-positive bacteria abundance, and decrease levels of inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Masaya Yokoyama, Motoko Y. Kimura, Toshihiro Ito, Koji Hayashizaki, Yukihiro Endo, Yangsong Wang, Ryoji Yagi, Tomoo Nakagawa, Naoya Kato, Hisahiro Matsubara, Toshinori Nakayama
Summary: This study found that Myl9/12 were highly expressed in patients with inflammatory bowel disease and mice with DSS-induced colitis. Administration of anti-Myl9/12 Ab alleviated inflammation and prolonged survival, indicating Myl9/12 may be a new therapeutic target for patients with IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Aikaterini Mantaka, Eleni Orfanoudaki, Ioannis E. Koutroubakis
INFLAMMATORY BOWEL DISEASES
(2019)
Article
Health Care Sciences & Services
Mairi Koulentaki, Ioannis Drygiannakis, Aikaterini Mantaka, Evangelos Moschapidakis, Anna Chalkiadaki, Aikaterini Augoustaki, Aspasia Spyridaki, Elias Kouroumalis, Anastasia Markaki
Summary: This study assessed the nutritional status of Greek liver cirrhosis (LC) patients and compared different assessment tools for predicting mortality. The study found a high prevalence of malnutrition in LC patients, but unexpectedly discovered a high proportion of well-nourished patients when evaluating nutritional status using various measurements. The Mini Nutritional Assessment (MNA) score was identified as a strong predictor of mortality.