High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
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Title
High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
Authors
Keywords
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Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 213, Issue 9, Pages 1819-1834
Publisher
Rockefeller University Press
Online
2016-07-25
DOI
10.1084/jem.20150598
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Note: Only part of the references are listed.- Immune-surveillance through exhausted effector T-cells
- (2016) Dietmar Zehn et al. Current Opinion in Virology
- Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells
- (2015) Pamela M. Odorizzi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Protective Efficacy of Individual CD8+T Cell Specificities in Chronic Viral Infection
- (2015) Susan Johnson et al. JOURNAL OF IMMUNOLOGY
- Overcoming T cell exhaustion in infection and cancer
- (2015) Kristen E. Pauken et al. TRENDS IN IMMUNOLOGY
- Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation
- (2014) Bertram Bengsch et al. JOURNAL OF HEPATOLOGY
- Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution
- (2014) Lalit K. Beura et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion
- (2013) Daniel T Utzschneider et al. NATURE IMMUNOLOGY
- Tolerance and exhaustion: defining mechanisms of T cell dysfunction
- (2013) Andrea Schietinger et al. TRENDS IN IMMUNOLOGY
- Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner
- (2013) Talyn Chu et al. Cell Reports
- Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells
- (2013) Amandine Legat et al. Frontiers in Immunology
- Clonal Exhaustion as a Mechanism to Protect Against Severe Immunopathology and Death from an Overwhelming CD8 T Cell Response
- (2013) Markus Cornberg et al. Frontiers in Immunology
- Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?
- (2012) Selena Viganò et al. Clinical & Developmental Immunology
- Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice
- (2012) Helge Frebel et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
- (2012) Sarah Enouz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection
- (2012) J. M. Angelosanto et al. JOURNAL OF VIROLOGY
- Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection
- (2012) M. A. Paley et al. SCIENCE
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
- (2010) Kirsten M.L. Hertoghs et al. JOURNAL OF CLINICAL INVESTIGATION
- Lack of Original Antigenic Sin in Recall CD8+ T Cell Responses
- (2010) D. Zehn et al. JOURNAL OF IMMUNOLOGY
- Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity
- (2010) Lukas Flatz et al. NATURE MEDICINE
- Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
- (2010) H.-T. Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation
- (2010) Bertram Bengsch et al. PLoS Pathogens
- Redefining Chronic Viral Infection
- (2009) Herbert W. Virgin et al. CELL
- Complete but curtailed T-cell response to very low-affinity antigen
- (2009) Dietmar Zehn et al. NATURE
- High antigen levels are the cause of T cell exhaustion during chronic viral infection
- (2009) S. N. Mueller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection
- (2009) J. S. Yi et al. SCIENCE
- IL-21 Is Required to Control Chronic Viral Infection
- (2009) H. Elsaesser et al. SCIENCE
- IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection
- (2009) A. Frohlich et al. SCIENCE
- Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
- (2009) Nobuhiro Nakamoto et al. PLoS Pathogens
- An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
- (2008) Alexandre Harari et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
- (2008) Shawn D Blackburn et al. NATURE IMMUNOLOGY
- Selective expansion of a subset of exhausted CD8 T cells by PD-L1 blockade
- (2008) S. D. Blackburn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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