The evolutionary and functional divergence of the Atg8 autophagy protein superfamily

Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses

(2022) Arindam Bhattacharjee et al.   Autophagy

LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

(2022) Hyun Jung Hwang et al.   Nature Communications

How the amino acid leucine activates the key cell-growth regulator mTOR

(2021) Tibor Vellai   NATURE

The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?

(2020) Marine Jacquet et al.   Autophagy

Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

(2020) Anne-Claire Jacomin et al.   Cell Reports

Emerging roles of ATG proteins and membrane lipids in autophagosome formation

(2020) Taki Nishimura et al.   Cell Discovery

Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB

(2020) Suresh Kumar et al.   Autophagy

Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles

(2020) András Jipa et al.   Autophagy

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

(2019) Anuradha Bhukel et al.   Nature Communications

Developmentally regulated autophagy is required for eye formation in Drosophila

(2018) Viktor Billes et al.   Autophagy

Analysis of Drosophila melanogaster testis transcriptome

(2018) Viktor Vedelek et al.   BMC GENOMICS

The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation

(2018) Tetsuya Kotani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Arl8 is a general positive regulator of lysosomal fusion events

(2018) Attila Boda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagosome Maturation and Fusion

(2017) Fulvio Reggiori et al.   JOURNAL OF MOLECULAR BIOLOGY

GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells

(2017) Laura Poillet-Perez et al.   Oncotarget

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms

(2017) Tibor Kovács et al.   Scientific Reports

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

GABARAP-mediated targeting of PI4K2A/PI4KIIα to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion

(2015) Joseph Albanesi et al.   Autophagy

Distinct requirements of Autophagy-related genes in programmed cell death

(2015) T Xu et al.   CELL DEATH AND DIFFERENTIATION

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome

(2015) T. Proikas-Cezanne et al.   JOURNAL OF CELL SCIENCE

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

(2015) David G. McEwan et al.   MOLECULAR CELL

Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy

(2015) Fan Wu et al.   MOLECULAR CELL

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Human GABARAP can restore autophagosome biogenesis in aC. elegans lgg-1mutant

(2014) Céline Jenzer et al.   Autophagy

The C. elegans LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39

(2014) Marion Manil-Ségalen et al.   DEVELOPMENTAL CELL

Hox Proteins Mediate Developmental and Environmental Control of Autophagy

(2014) Agnes Banreti et al.   DEVELOPMENTAL CELL

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

(2014) A. H. Lystad et al.   EMBO REPORTS

Omegasomes: PI3P platforms that manufacture autophagosomes

(2013) Rebecca Roberts et al.   Essays in Biochemistry

Uba1 functions in Atg7- and Atg3-independent autophagy

(2013) Tsun-Kai Chang et al.   NATURE CELL BIOLOGY

Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

(2013) Chen-Chen Tan et al.   NEUROBIOLOGY OF AGING

Specific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1

(2013) Jaclyn Nicole Le Grand et al.   PLoS One

Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage

(2013) Martina Wirth et al.   SEMINARS IN CANCER BIOLOGY

Dual roles of Atg8−PE deconjugation by Atg4 in autophagy

(2012) Zhong-Qiu Yu et al.   Autophagy

Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis

(2012) Hitoshi Nakatogawa et al.   Autophagy

Selective autophagy in budding yeast

(2012) Kuninori Suzuki   CELL DEATH AND DIFFERENTIATION

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans

(2010) Adriana Alberti et al.   Autophagy

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

Atg8 regulates vacuolar membrane dynamics in a lipidation-independent manner in Pichia pastoris

(2010) Naoki Tamura et al.   JOURNAL OF CELL SCIENCE

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

The Amphimedon queenslandica genome and the evolution of animal complexity

(2010) Mansi Srivastava et al.   NATURE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Links between Autophagy, Innate Immunity, Inflammation and Crohn’s Disease

(2009) Vojo Deretic   DIGESTIVE DISEASES

The regulation of aging: does autophagy underlie longevity?

(2009) Tibor Vellai et al.   TRENDS IN CELL BIOLOGY

Specific regional distribution of gec1 mRNAs in adult rat central nervous system

(2008) Fabrice Tolle et al.   BRAIN RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Atg8 Controls Phagophore Expansion during Autophagosome Formation

(2008) Zhiping Xie et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE