PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma

SuperPlotsOfData – a web app for the transparent display and quantitative comparison of continuous data from different conditions

(2021) Joachim Goedhart   MOLECULAR BIOLOGY OF THE CELL

Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets

(2021) Krzysztof Kotowski et al.   Cancers

High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer

(2019) Ling Yao et al.   Cancer Cell International

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

(2018) Subhamoy Dasgupta et al.   NATURE

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates

(2017) Jean-Louis Plouhinec et al.   PLOS BIOLOGY

HIF-1α activates hypoxia-induced PFKFB4 expression in human bladder cancer cells

(2016) Hao Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells

(2016) Christian Posch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphorylation of PPARγ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4

(2016) Yuxin Shu et al.   Oncotarget

Targeting protein kinase CK2 suppresses bladder cancer cell survival via the glucose metabolic pathway

(2016) Xiaolei Zhang et al.   Oncotarget

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening

(2015) A M Strohecker et al.   ONCOGENE

PFKFB4 controls embryonic patterning via Akt signalling independently of glycolysis

(2015) Caterina Pegoraro et al.   Nature Communications

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor

(2015) Jason Chesney et al.   Oncotarget

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis

(2015) Florian Rambow et al.   Cell Reports

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

(2015) Jason Chesney et al.   Oncotarget

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

(2014) Julia Petschnigg et al.   NATURE METHODS

BRAF/NRASwild-type melanoma, NF1 status and sensitivity to trametinib

(2014) Marco Ranzani et al.   Pigment Cell & Melanoma Research

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

(2014) Oleksandr H Minchenko   WORLD JOURNAL OF GASTROENTEROLOGY

Melanoma epidemiology, biology and prognosis

(2013) Z. Ali et al.   EJC SUPPLEMENTS

Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) isoforms display a tissue-specific and dynamic expression during Xenopus laevis development

(2013) Caterina Pegoraro et al.   GENE EXPRESSION PATTERNS

Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival

(2012) Susana Ros et al.   Cancer Discovery

B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance

(2012) Agathe Valluet et al.   Cell Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival

(2011) V Goidts et al.   ONCOGENE

PFKFB4 as a prognostic marker in non-muscle-invasive bladder cancer

(2011) Seok Joong Yun et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe

(2009) L. P. Wright et al.   MOLECULAR AND CELLULAR BIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS