The Effect of Leucine Supplementation on Sarcopenia-Related Measures in Older Adults: A Systematic Review and Meta-Analysis of 17 Randomized Controlled Trials

Prevalence, Incidence, and Associated Factors of Possible Sarcopenia in Community-Dwelling Chinese Older Adults: A Population-Based Longitudinal Study

(2022) Zi Chen et al.   Frontiers in Medicine

Effect of vitamin D monotherapy on indices of sarcopenia in community‐dwelling older adults: a systematic review and meta‐analysis

(2022) Konstantinos Prokopidis et al.   Journal of Cachexia Sarcopenia and Muscle

Dose–response relationships of sarcopenia parameters with incident disability and mortality in older Japanese adults

(2022) Satoshi Seino et al.   Journal of Cachexia Sarcopenia and Muscle

Mitochondrial Content, but Not Function, Is Altered With a Multimodal Resistance Training Protocol and Adequate Protein Intake in Leucine-Supplemented Pre/Frail Women

(2021) Kathryn J. Jacob et al.   Frontiers in Nutrition

Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n–3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial

(2021) Caoileann H Murphy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Isolated Leucine and Branched-Chain Amino Acid Supplementation for Enhancing Muscular Strength and Hypertrophy: A Narrative Review

(2021) Daniel L. Plotkin et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Higher Branched-Chain Amino Acid Intake Is Associated with Handgrip Strength among Korean Older Adults

(2021) Seonghee Park et al.   Nutrients

Supplement-based nutritional strategies to tackle frailty: A multifactorial, double-blind, randomized placebo-controlled trial

(2021) Hamilton Roschel et al.   CLINICAL NUTRITION

Vitamin D and Muscle Health: A Systematic Review and Meta‐analysis of Randomized Placebo‐Controlled Trials

(2021) Lise Sofie Bislev et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Signatures and Clinical Significance of Amino Acid Flux in Sarcopenia: A Systematic Review and Meta-Analysis

(2021) Miao Dai et al.   Frontiers in Endocrinology

The effects of glucagon and the target of rapamycin (TOR) on skeletal muscle protein synthesis and age-dependent sarcopenia in humans

(2021) María M. Adeva-Andany et al.   Clinical Nutrition ESPEN

Relationship between malnutrition and sarcopenia in elderly Turkish community-dwellers

(2021) Gökcen Doğan et al.   Nutrition Clinique et Metabolisme

Daily Leucine Intake Is Positively Associated with Lower Limb Skeletal Muscle Mass and Strength in the Elderly

(2021) Manoel E. Lixandrão et al.   Nutrients

Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial

(2020) Francisco M. Martínez-Arnau et al.   Nutrients

Over-expression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy

(2020) Joseph J. Bass et al.   Molecular Metabolism

Effects of adequate dietary protein with whey protein, leucine, and vitamin D supplementation on sarcopenia in older adults: An open-label, parallel-group study

(2020) Chih-Chien Lin et al.   CLINICAL NUTRITION

Improving rehabilitation in sarcopenia: a randomized‐controlled trial utilizing a muscle‐targeted food for special medical purposes

(2020) Mariangela Rondanelli et al.   Journal of Cachexia Sarcopenia and Muscle

Exercise and Dietary-Protein as a Countermeasure to Skeletal Muscle Weakness: Liverpool Hope University – Sarcopenia Aging Trial (LHU-SAT)

(2019) Ben Kirk et al.   Frontiers in Physiology

Sarcopenia

(2019) Alfonso J Cruz-Jentoft et al.   LANCET

Muscle-targeted nutritional support for rehabilitation in patients with parkinsonian syndrome

(2019) Michela Barichella et al.   NEUROLOGY

Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial

(2019) Maria Amasene et al.   Nutrients

Current protein and amino acid intakes among Japanese people: Analysis of the 2012 National Health and Nutrition Survey

(2018) Kazuko Ishikawa-Takata et al.   Geriatrics & Gerontology International

Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells

(2018) Yuma HIROSE et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Diet Quality and Sarcopenia in Older Adults: A Systematic Review

(2018) Ilse Bloom et al.   Nutrients

An Update on Protein, Leucine, Omega-3 Fatty Acids, and Vitamin D in the Prevention and Treatment of Sarcopenia and Functional Decline

(2018) Anne-Julie Tessier et al.   Nutrients

The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial

(2018) M Kyla Shea et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Supplementing Breakfast with a Vitamin D and Leucine–Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men

(2017) Audrey Chanet et al.   JOURNAL OF NUTRITION

Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly

(2016) Mariangela Rondanelli et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans

(2016) Jheelam Banerjee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leucine in Obesity: Therapeutic Prospects

(2016) Kang Yao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise

(2015) Syed S. I. Bukhari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis

(2015) Zhe-rong Xu et al.   BRITISH JOURNAL OF NUTRITION

Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 65–75 years

(2015) T Ispoglou et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial

(2015) Jürgen M. Bauer et al.   Journal of the American Medical Directors Association

A high whey protein–, leucine-, and vitamin D–enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial

(2014) Amely M Verreijen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Age-associated decline of muscle mass, grip strength and gait speed: A 4-year longitudinal study of 3018 community-dwelling older Chinese

(2014) Tung Wai Auyeung et al.   Geriatrics & Gerontology International

Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: A systematic review and meta-analysis

(2014) B. Komar et al.   Journal of Nutrition Health & Aging

Leucine Supplementation Improves Skeletal Muscle Regeneration after Cryolesion in Rats

(2014) Marcelo G. Pereira et al.   PLoS One

Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein

(2012) Shanon L. Casperson et al.   CLINICAL NUTRITION

Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men

(2012) Benjamin T. Wall et al.   CLINICAL NUTRITION

Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men

(2011) Marika Leenders et al.   JOURNAL OF NUTRITION

Effects of Exercise and Amino Acid Supplementation on Body Composition and Physical Function in Community-Dwelling Elderly Japanese Sarcopenic Women: A Randomized Controlled Trial

(2011) Hun Kyung Kim et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People

(2010) A. J. Cruz-Jentoft et al.   AGE AND AGEING

An overview of sarcopenia: facts and numbers on prevalence and clinical impact

(2010) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men

(2009) Suzanne Verhoeven et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Influence of leucine infusion on intracellular amino acids in humans

(2008) A. ALVESTRAND et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals

(2008) M. Pfeifer et al.   OSTEOPOROSIS INTERNATIONAL