PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value

Pim-3 contributes to radioresistance through regulation of the cell cycle and DNA damage repair in pancreatic cancer cells

(2016) Xiang-Yuan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization

(2016) Yang Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages

(2016) Qiaofei Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Regulation of prostate stromal fibroblasts by the PIM1 protein kinase

(2015) Marina Y. Zemskova et al.   CELLULAR SIGNALLING

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

(2015) Niina M. Santio et al.   PLoS One

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine

(2015) Chen Liang et al.   Oncotarget

PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells

(2015) Allan Siu et al.   Oncotarget

Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and Is under the Control of Epidermal Growth Factor Receptor

(2015) Katriina Peltola et al.   NEOPLASIA

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

EGFR as a Potential Target for the Treatment of Pancreatic Cancer: Dilemma and Controversies

(2014) Reza Nedaeinia et al.   CURRENT DRUG TARGETS

PIM kinases: an overview in tumors and recent advances in pancreatic cancer

(2014) Jianwei Xu et al.   Future Oncology

The multiple facets of drug resistance: one history, different approaches

(2014) Evandro Niero et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

(2013) E. K. Keeton et al.   BLOOD

Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine

(2013) Dapeng Xu et al.   CANCER BIOLOGY & THERAPY

Combination of Pim Kinase Inhibitor SGI-1776 and Bendamustine in B-Cell Lymphoma

(2013) Qingshan Yang et al.   Clinical Lymphoma Myeloma & Leukemia

Pim-3 promotes the growth of human pancreatic cancer in the orthotopic nude mouse model through vascular endothelium growth factor

(2013) Chen Wang et al.   JOURNAL OF SURGICAL RESEARCH

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms

(2012) Karthika Natarajan et al.   BIOCHEMICAL PHARMACOLOGY

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities

(2012) Carmen Blanco-Aparicio et al.   BIOCHEMICAL PHARMACOLOGY

The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells

(2012) M.-A. Hospital et al.   BLOOD

Nestin and other putative cancer stem cell markers in pancreatic cancer

(2012) Yoko Matsuda et al.   Medical Molecular Morphology

EZH2 Is Required for Breast and Pancreatic Cancer Stem Cell Maintenance and Can Be Used as a Functional Cancer Stem Cell Reporter

(2012) Lilian E. van Vlerken et al.   Stem Cells Translational Medicine

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

(2011) D. Xu et al.   CARCINOGENESIS

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

(2010) Carolin Reiser-Erkan et al.   CANCER BIOLOGY & THERAPY

PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

(2010) Fengxue Zhang et al.   CANCER BIOLOGY & THERAPY

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

(2010) Carmen Blanco-Aparicio et al.   CANCER LETTERS

Overexpression of Pim-1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma

(2010) Hong-Tao Liu et al.   JOURNAL OF SURGICAL ONCOLOGY

Pim-1 Kinase Protects P-Glycoprotein from Degradation and Enables Its Glycosylation and Cell Surface Expression

(2010) Y. Xie et al.   MOLECULAR PHARMACOLOGY

Pancreatic cancer: understanding and overcoming chemoresistance

(2010) Zhiwei Wang et al.   Nature Reviews Gastroenterology & Hepatology

EGFR signaling in breast cancer: Bad to the bone

(2010) John Foley et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

(2009) J J Gu et al.   ONCOGENE

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

(2008) Yunsong Tong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH