EZH2 Is Required for Breast and Pancreatic Cancer Stem Cell Maintenance and Can Be Used as a Functional Cancer Stem Cell Reporter

The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models

(2012) M. Mizuma et al.   MOLECULAR CANCER THERAPEUTICS

Absence of CD71 Transferrin Receptor Characterizes Human Gastric Adenosquamous Carcinoma Stem Cells

(2011) Masahisa Ohkuma et al.   ANNALS OF SURGICAL ONCOLOGY

Silencing ofhHS6ST2inhibits progression of pancreatic cancer through inhibition of Notch signalling

(2011) Kai Song et al.   BIOCHEMICAL JOURNAL

Salinomycin can effectively kill ALDHhigh stem-like cells on gastric cancer

(2011) Qiao Ming Zhi et al.   BIOMEDICINE & PHARMACOTHERAPY

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells

(2011) Guan-Nan Zhang et al.   CANCER LETTERS

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

(2011) J. Stagg et al.   CANCER RESEARCH

XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells

(2011) Zhaoquan Xing et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer

(2011) Francesco Crea et al.   Molecular Cancer

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells

(2011) M C Anania et al.   ONCOGENE

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

(2011) S Floor et al.   ONCOGENE

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

(2011) F Yu et al.   ONCOGENE

Rac1 Targeting Suppresses Human Non-Small Cell Lung Adenocarcinoma Cancer Stem Cell Activity

(2011) Shailaja Akunuru et al.   PLoS One

Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway

(2011) Igor Paron et al.   PLoS One

GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1

(2011) Yi Zhong et al.   PLoS One

The Importance of the Stem Cell Marker Prominin-1/CD133 in the Uptake of Transferrin and in Iron Metabolism in Human Colon Cancer Caco-2 Cells

(2011) Erika Bourseau-Guilmain et al.   PLoS One

RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo

(2010) Yangchao Chen et al.   CANCER LETTERS

Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma ofPtch-Mutant Mice via CaMKII

(2010) Frauke Nitzki et al.   CANCER RESEARCH

Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in “Stem-Cell-Like” Tumor Cells

(2010) Zhiyong Du et al.   DIGESTIVE DISEASES AND SCIENCES

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma

(2010) Adam D. Toll et al.   HUMAN PATHOLOGY

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Epigenetic regulation of signaling pathways in cancer: Role of the histone methyltransferase EZH2

(2010) Daisy PF Tsang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cancer stem cells: problems for therapy?

(2010) Malcolm R Alison et al.   JOURNAL OF PATHOLOGY

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming

(2009) O. Sripichai et al.   BLOOD

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells

(2009) Sung Pil Hong et al.   INTERNATIONAL JOURNAL OF CANCER

The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies

(2009) Brett G. Hollier et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Interaction between CXCR4 and CCL20 Pathways Regulates Tumor Growth

(2009) Katia Beider et al.   PLoS One

Therapeutic Implications of the Cancer Stem Cell Hypothesis

(2009) Maximilian Diehn et al.   SEMINARS IN RADIATION ONCOLOGY

Stem cell regulation by polycomb repressors: postponing commitment

(2008) Alexandra M Pietersen et al.   CURRENT OPINION IN CELL BIOLOGY

Expression of the fras1/frem gene family during zebrafish development and fin morphogenesis

(2008) Philippe Gautier et al.   DEVELOPMENTAL DYNAMICS

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL