Thinking about Enhanced Permeability and Retention Effect (EPR)

The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application

(2021) Jun Wu   Journal of Personalized Medicine

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

(2016) F. Danhier   JOURNAL OF CONTROLLED RELEASE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect

(2013) Hiroshi Maeda   CANCER SCIENCE

Markedly Enhanced Permeability and Retention Effects Induced by Photo-immunotherapy of Tumors

(2012) Kohei Sano et al.   ACS Nano

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Tumor delivery of macromolecular drugs based on the EPR effect

(2010) Vladimir Torchilin   ADVANCED DRUG DELIVERY REVIEWS

Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: Analogy between angina pectoris and solid tumors and enhancement of the EPR effect

(2010) Hiroshi Maeda   JOURNAL OF CONTROLLED RELEASE

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine