Review
Biochemistry & Molecular Biology
Marina Ruxandra Otelea, Oana Cristina Arghir, Corina Zugravu, Agripina Rascu
Summary: Adiponectin is a molecule associated with the healthy obese phenotype, affecting insulin sensitivity and providing cardiovascular protection. Studies suggest a potential role of adiponectin in asthma, but its specific effects are still controversial. Research focuses on the mechanisms of adiponectin and its impact on the pathobiology of asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Rosaria Anna Fontanella, Lucia Scisciola, Maria Rosaria Rizzo, Surina Surina, Celestino Sardu, Raffaele Marfella, Giuseppe Paolisso, Michelangela Barbieri
Summary: The study confirmed the role of epigenetics in obesity-related cardiovascular complications, and proposed plasma miRNA-21 and IL-6 as well as NF-kB DNA methylation changes in nucleated blood cells as potential biomarkers for evaluating cardiovascular risk in obesity. It also showed the protective role of adiponectin in preventing epigenetic modifications induced by increased adipose tissue content in obese individuals. Further research is needed to explore the exact mechanisms of obesity-related epigenetic modifications in blood cells and their reflection of changes in adipose and myocardial tissues.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Monica Zocchi, Matteo Della Porta, Federico Lombardoni, Roberta Scrimieri, Gian Vincenzo Zuccotti, Jeanette A. Maier, Roberta Cazzola
Summary: Obesity is a major public health issue associated with low-grade chronic inflammation and increased cardiovascular risks. The interaction between adiponectin and HDLs is crucial, especially in obese individuals.
Article
Endocrinology & Metabolism
Luigi Di Filippo, Rebecca De Lorenzo, Clara Sciorati, Annalisa Capobianco, Nicola Lore, Andrea Giustina, Angelo A. Manfredi, Patrizia Rovere-Querini, Caterina Conte
Summary: In this study, the Adpn/Lep ratio was found to be significantly different among COVID-19 patients of varying severity, and it was positively correlated with systemic inflammation, indicating a compensatory response mechanism. Patients with higher Adpn/Lep ratios were associated with better health conditions and lower mortality rates.
DIABETES & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Isabell Kaczmarek, Isabel Wower, Katja Ettig, Christina Katharina Kuhn, Robert Kraft, Kathrin Landgraf, Antje Koerner, Torsten Schoeneberg, Susanne Horn, Doreen Thor
Summary: This study established an interactive public database, FATTLAS, for improved access and analysis of RNA-seq data of mouse and human adipose tissue. Highly expressed and differentially regulated GPCRs were identified by extracting the GPCRome of non-obese and obese individuals. Four receptors (GPR146, MRGPRF, FZD5, PTGER2) were analyzed for their functions in a (pre)adipocyte cell model.
Article
Pediatrics
Carolina Ochoa-Rosales, Lorena Mardones, Marcelo Villagran, Claudio Aguayo, Miquel Martorell, Carlos Celis-Morales, Natalia Ulloa
Summary: Children carrying the 'A' allele at the FTO gene have higher obesity prevalence. A cross-sectional study was conducted on 323 children aged 6-11 years to examine the relationship between FTO rs9939609 polymorphism and plasma adiponectin, and the mediating role of body adiposity. Linear regressions and mediation analysis were used to analyze the data. The study found that body adiposity may mediate up to 29.8% of the association between FTO and adiponectin.
Article
Nutrition & Dietetics
Rawan Nehme, Arthur Chervet, Caroline Decombat, Lucie Longechamp, Adrien Rossary, Rebecca Boutin, Amandine Rousset, Francois Senejoux, Caroline Vachias, Celine Auxenfans, Didier Fraisse, Jean-Baptiste Guyon, Edith Filaire, Jean-Yves Berthon, Mona Diab-Assaf, Laetitia Delort, Florence Caldefie-Chezet
Summary: Polyphenols and flavonoids in Rooibos tea can reduce obesity and inflammation by reducing ROS production and pro-inflammatory cytokine secretion, inhibiting macrophage polarization, and decreasing lipid accumulation and adipogenesis.
Review
Endocrinology & Metabolism
Hai Jiang, Yu Pu, Zeng-Hui Li, Wei Liu, Yan Deng, Rui Liang, Xiao-Ming Zhang, Hou-Dong Zuo
Summary: Osteoarthritis (OA) is a common joint disease in elderly individuals, caused by chronic inflammation and abnormal lipid metabolism. Adiponectin, as a adipokine, may have a protective effect on OA by regulating inflammatory factors and lipid metabolism.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Cristina Barale, Elena Melchionda, Alessandro Morotti, Isabella Russo
Summary: COVID-19 infection is associated with a range of symptoms, with alveolar capillary microthrombi being a common finding, likely due to severe endothelial injury. This suggests a COVID-19-related coagulopathy may worsen thrombosis, organ damage, severity, and mortality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Yunlin Ge, Siqi Li, Tao Yao, Yuexiao Tang, Qiangyou Wan, Xiaoli Zhang, Jing Zhao, Mingliang Zhang, Mengle Shao, Lijun Wang, Ying Wu
Summary: Sarcopenic obesity, which refers to obesity combined with sarcopenia, poses risks to the aging population. The complex etiology of this condition has hindered the development of effective treatments. Recent research has shown that the way adipose tissue remodels itself is important for metabolic health in obesity. Healthy remodeling of adipose tissue provides metabolic protection to non-adipose tissues, including skeletal muscle. In this study, the effects of inactivating the HIF1 alpha gene in adipocytes on muscle protection were evaluated. The findings indicate that inactivating adipocyte HIF1 alpha improves metabolic health, reduces levels of lipids and pro-inflammatory molecules, and increases adipokine circulation in obese mice. These effects also contribute to lower muscle inflammation. The study suggests that promoting healthy remodeling of adipose tissue may be a new therapeutic strategy for improving muscle health in sarcopenic obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Immunology
Andrew N. Bubak, Christina Coughlan, Janelle Posey, Anthony J. Saviola, Christy S. Niemeyer, Serena W. R. Lewis, Sara Bustos Lopez, Adriana Solano, Stephen K. Tyring, Cassidy Delaney, Keith B. Neeves, Ravi Mahalingam, Kirk C. Hansen, Maria A. Nagel
Summary: Herpes zoster (HZ; shingles) increases the risk of stroke, possibly due to the activation of platelets and formation of platelet-leukocyte aggregates by plasma exosomes from HZ patients. These findings suggest potential prothrombotic mechanisms that can be targeted for reducing stroke risk.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Ruben Garcia-Martin, Bruna Brasil Brandao, Thomas Thomou, Emrah Altindis, C. Ronald Kahn
Summary: Exosomes/small extracellular vesicles (sEVs) can mediate cell-to-cell communication through their miRNA and protein cargo. Each cell type has a unique sEV proteome, but there are also common markers. Specific markers of different cell types can predict the tissue of origin of serum sEVs, as demonstrated in a mouse model.
Review
Geriatrics & Gerontology
Yuanyuan Zhou, Ying Yang, Taicheng Zhou, Bai Li, Zhanjian Wang
Summary: Thyroid cancer has seen a sharp rise in incidence in recent decades, becoming the most common endocrine cancer worldwide. Obesity is identified as an independent risk factor for thyroid cancer, with focus on adiponectin as a key adipocytokine. Research exploring the relationship between adiponectin, obesity, and thyroid cancer is gaining increasing attention.
Review
Biochemistry & Molecular Biology
Sebastian Dommel, Matthias Bluher
Summary: Obesity is associated with adipose tissue dysfunction, leading to metabolic inflammation and increased immune cell infiltration, with CCL2 playing a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Emine Vezir, Ersoy Civelek, Emine Dibek Misirlioglu, Muge Toyran, Murat Capanoglu, Esra Karakus, Tamer Kahraman, Meltem Ozguner, Fatma Demirel, Ihsan Gursel, Can Naci Kocabas
Summary: The study found an interaction between obesity and asthma in children, manifested in airway and systemic inflammation. Obesity and asthma can affect levels of inflammatory markers in the body, but no significant interaction was found in terms of airway inflammation.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Food Science & Technology
Hee-Sook Park, Haeng Jeon Hur, Soon-Hee Kim, Su-Jin Park, Moon Ju Hong, Mi Jeong Sung, Dae Young Kwon, Myung-Sunny Kim
MOLECULAR NUTRITION & FOOD RESEARCH
(2016)
Article
Multidisciplinary Sciences
Moonju Hong, Jeeyoun Jung, Hee-Sook Park, So Min Lee, Nam-Joo Jeong, Soon-Hee Kim, Kyoung-Won Lee, Ju-A Lee, Myung-Sunny Kim
Article
Food Science & Technology
Soon-Hee Kim, Hee-Sook Park, Moon Ju Hong, Haeng Jeon Hur, Dae Young Kwon, Myung-Sunny Kim
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)