Article
Chemistry, Medicinal
Luciane M. Monteiro, Lislaine M. Klider, Aline A. M. Marques, Paulo V. Farago, Janaina Emiliano, Roosevelt I. C. Souza, Ariany C. dos Santos, Vera L. P. dos Santos, Mei Wang, Nadla S. Cassemiro, Denise B. Silva, Ikhlas A. Khan, Arquimedes Gasparotto Junior, Jane Manfron
Summary: This study investigated the use of Piper amalago in Brazilian traditional medicine and its effects on the kidneys and cardiovascular system. The results showed that Piper amalago leaves are safe and have diuretic effects, and can induce significant vasodilatory response by activating the NO/cGMP pathway and voltage-dependent K+ channels.
Article
Medicine, Legal
Julia Stein, Barbara Campos Jorge, Ana Carolina Casali Reis, Joyce Alencar Santos Radai, Suyane da Silva Moreira, Thiago Leite Fraga, Jonas da Silva Mota, Rodrigo Juliano Oliveira, Candida Aparecida Leite Kassuya, Arielle Cristina Arena
Summary: This study evaluated the toxicological safety of ethanolic extract from Piper amalago leaves (EEPA) through subacute toxicity and genotoxicity assays. The results showed that EEPA had hemato-biochemical toxicity profile in rats, suggesting cautious use, especially for a prolonged period.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Fan Yang, Hua Li, Yan-Qiu Yang, Yue Hou, Dong Liang
Summary: In this study, four new lignanamides and four known analogs were isolated from the stems of Piper hancei Maxim. These compounds exhibited potential inhibitory effects on NO production in BV-2 microglial cells and moderate cytotoxic activities against certain types of cells.
Article
Chemistry, Medicinal
Fan Yang, Hua Li, Yan-Qiu Yang, Yue Hou, Dong Liang
Summary: Four new lignanamides and four known analogs were isolated from the stems of Piper hancei Maxim. These compounds showed potential inhibitory effects on NO production in LPS-induced BV-2 microglial cells, and exhibited moderate cytotoxic activities against various cancer cell lines.
Article
Agricultural Engineering
Jeferson Adriano e Silva Assuncao, Diego da Silva Marcelino, Jessica Regina Sales Felisberto, Elsie Fraklin Guimaraes, George de Azevedo Queiroz, Ygor Jesse Ramos, Davyson de Lima Moreira
Summary: This study aimed to assess the post-harvest impact of UV-C irradiation on the metabolic profile of essential oils (EOs) from fresh leaves of Piper aduncum cultivated in Southeastern Brazil. The results showed that UV-C radiation can alter the relative percentage of specific chemical constituents, with a significant increase in the relative percentage of the compound dillapiole. This study suggests that UV-C irradiation may be a promising technique for enriching the dillapiole content in the essential oil of P. aduncum.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Plant Sciences
Armelle T. Mbaveng, Brice E. N. Wamba, Gabin T. M. Bitchagno, Simplice Beaudelaire Tankeo, Ilhami Celik, Brice C. K. Atontsa, Antoine H. Nkuete Lonfouo, Victor Kuete, Thomas Efferth
Summary: Piper capense is a medicinal spice with potential cytotoxic effects against various cancer cell lines, especially compound 2 and PCFb, which induce apoptosis in cancer cells. These findings suggest that Piper capense could be explored further for developing new drugs to combat malignancies.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andre M. Marques, Alexandre Siqueira da Rocha Queiroz, Elsie F. Guimaraes, Ana Carolina Mafud, Paulo de Sousa Carvalho, Yvonne Primerano Mascarenhas, Thais da Silva Barenco, Pamella Dourila N. Souza, David William Provance, Jose Hamilton M. do Nascimento, Cristiano G. Ponte, Maria Auxiliadora C. Kaplan, Davyson de Lima Moreira, Maria Raquel Figueiredo
Summary: Piper species, especially Piper tectoniifolium Kunth, are potential natural sources of the bioactive compound (-)-grandisin. A new method for identifying (-)-grandisin was developed, and the molecule was found to have a vasorelaxant effect. These findings suggest that P. tectoniifolium has the potential to be a renewable source of grandisin and a template for the development of new drugs.
Article
Plant Sciences
Ygor Jesse Ramos, Jessica Sales Felisberto, Joao Gabriel Gouvea-Silva, Ulisses Carvalho de Souza, Claudete da Costa-Oliveira, George Azevedo de Queiroz, Elsie Franklin Guimaraes, Nicholas John Sadgrove, Davyson de Lima Moreira
Summary: This study tested the hypothesis that clonal chemical heritability is crucial for the conservation of chemical uniformity in controlled monoclonal cultivation of Piper essential oils. The results showed that while clonal heritability is important for chemical homology, significant chemical plasticity can occur when cultivated from wild specimens.
Article
Biochemistry & Molecular Biology
Carlos Eduardo P. Maduro, Rebeca G. de Camargo, Ana Paula P. K. Hendges, Aurea P. Ferriani, Allan R. da Silva, Marta Cristina T. Duarte, Wanderlei do Amaral, Beatriz Helena L. N. Sales Maia
Summary: This study evaluated the seasonal variation of the chemical composition and antimicrobial activity of Piper caldense and Piper xylosteoides leaves essential oils. Different seasons and plant species have an impact on the composition and activity of the essential oils.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Environmental Sciences
Leandro P. Franca, Ana Claudia F. Amaral, Aline de S. Ramos, Jose Luiz P. Ferreira, Ana Clara B. Maria, Kelson Mota T. Oliveira, Earle S. Araujo, Adjane Dalvana S. Branches, Jonathas N. Silva, Noam G. Silva, Gabriel de A. Barros, Francisco Celio M. Chaves, Wanderli P. Tadei, Jefferson Rocha de A. Silva
Summary: Mosquitoes, particularly Aedes aegypti and Aedes albopictus, are important vectors of diseases like dengue and Zika worldwide. Essential oils extracted from plants, such as Piper capitarianum, show insecticidal potential against these mosquitoes and are environmentally friendly.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Yu Juan Chai, Younghoon Go, Hai Qi Zhou, Hong Xu Li, Sun Joo Lee, Yeo Jin Park, Wahyu Widowatib, Rizal Rizal, Young Ho Kim, Seo Young Yang, Wei Li
Summary: Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from Piper crocatum leaves. Their chemical structures were elucidated through spectroscopic analyses and compared with previous data. Two compounds showed strong inhibitory effects against pyruvate dehydrogenase E1 alpha S300 phosphorylation in comparison to the positive control.
Article
Entomology
Nancy Alonso-Hernandez, Carlos Granados-Echegoyen, Ileana Vera-Reyes, Rafael Perez-Pacheco, Fabian Arroyo-Balan, Alejandro Valdez-Calderon, Arian Espinosa-Roa, Henry Jesus Loeza-Concha, Evert Villanueva-Sanchez, Florinda Garcia-Perez, Fidel Diego-Nava
Summary: Mosquitoes are a significant threat to human health due to their ability to transmit various diseases. Plant-derived products, such as essential oils, offer an alternative and sustainable option for controlling mosquito populations. The essential oil extracted from the endemic plant Piper cordoncillo var. apazoteanum demonstrated effective control of Aedes aegypti larvae, while also providing valuable information on the plant's chemical composition.
Article
Multidisciplinary Sciences
Vanessa F. S. Ayres, Midia R. Oliveira, Edson L. L. Baldin, Geone M. Correa, Anderson C. Guimaraes, Renata Takeara
Summary: The study showed that the essential oils of Piper callosum and Vitex agnus-castus have potential fumigant toxicity against Zabrotes subfasciatus, providing an alternative method for controlling pests in stored products.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2021)
Article
Agronomy
Camila Soledade de Lira Pimentel, Bheatriz Nunes de Lima Albuquerque, Suyana Karolyne Lino da Rocha, Andre Severino da Silva, Alana Bittencourt Vieira da Silva, Remi Bellon, Afonso Cordeiro Agra-Neto, Julio Cesar Ribeiro de Oliveira Farias de Aguiar, Patricia Maria Guedes Paiva, Jefferson Luiz Princival, Thiago Henrique Napoleao, Daniela Maria do Amaral Ferraz Navarro
Summary: The study demonstrated that PcLEO and BMDB exhibited insecticidal activity against S. zeamais, with toxic effects by fumigation, contact, and ingestion, as well as strong food deterrence and inhibition of trypsin and alpha-amylase activities. These results suggest the potential use of PcLEO and BMDB in pest control.
PEST MANAGEMENT SCIENCE
(2022)
Article
Plant Sciences
Nina Reis Soares, Caio Tulio Rodrigues Correa, Jhonata Costa da Silva, Jacson Rondinelli da Silva Negreiros, Vania Helena Techio, Giovana Augusta Torres
Summary: The species Piper hispidinervum, Piper aduncum, and Piper affinis hispidinervum have essential oils with different compounds, and their taxonomy is controversial due to morphological similarities. Detailed analysis of their karyotypes and rDNA sites revealed similar traits, indicating difficulty in differentiation. Genomic hybridization showed high similarity in repetitive DNA fraction among the species, emphasizing the need for further genomic studies to resolve taxonomic controversy.
Article
Neurosciences
Elisangela Dos Santos, Joyce Alencar Santos Radai, Kamilla Felipe do Nascimento, Anelise Samara Nazari Formagio, Natalia de Matos Balsalobre, Edward Benjamin Ziff, Elisabete Castelon Konkiewitz, Candida Aparecida Leite Kassuya
Summary: This study demonstrates that the essential oil from Psidium guineense leaves has anti-nociceptive and anti-hyperalgesic effects in acute and continuous treatment, and exhibits anxiolytic and antidepressive effects in the experimental state of chronic pain.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Immunology
Roberto Mikio Kassuya, Joyce Alencar Santos Radai, Luis Fernando Benitez Macorini, Viktor Krejci Nunes, Marcos Jose Salvador, Patricia Regina Terco Leite, Rodrigo Juliano Oliveira, Julio Croda, Arielle Cristina Arena, Candida Aparecida Leite Kassuya
Summary: The study demonstrates the anti-inflammatory and antibiotic properties of ethanolic extracts obtained from Blutaparon portulacoides stem, suggesting the potential development of safe new drugs with dual anti-inflammatory/antimycobacterial activities.
INFLAMMOPHARMACOLOGY
(2021)
Article
Cell Biology
Roberto Mikio Kassuya, Elisangela dos Santos, Fernando Henrique Bosso, Taise Fonseca Pedroso, Jane Vasconcelos Neves Marinho, Marcos Jose Salvador, Candida Aparecida Leite Kassuya, Arquimedes Gasparotto Junior
Summary: The study confirmed the anti-inflammatory properties of ethanolic extract from Alternanthera tenella Colla (Amaranthaceae) whole plant and the flavone C-glycoside A19, showing significant inhibitory effects on edema, hyperalgesia, leukocyte migration, and enzyme activities associated with inflammation. Additionally, in silico analysis indicated the potential of A19 as a TNF-alpha inhibitor, further supporting its anti-inflammatory effects.
Article
Plant Sciences
Sher Ali, Katlin S. Rech, Gul Badshah, Frederico L. F. Soares, Andersson Barison
Summary: The study evaluates the authenticity of collected and commercial M. ilicifolia samples using metabolomics fingerprinting and principal component analysis, showing that plant specimen types from different habitats and seasons may affect metabolic profiles.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Nutrition & Dietetics
Luane Aparecida do Amaral, Taina da Silva Fleming de Almeida, Gabriel Henrique Oliveira de Souza, Adrivanio Baranoski, Rafael Souza Maris, Felipe Francisco Bittencourt Junior, Bruna Paola Murino Rafacho, Antonio Carlos Duenhas Monreal, Candida Aparecida Leite Kassuya, Andreia Conceicao Milan Brochado Antoniolli-Silva, Elisvania Freitas dos Santos, Rodrigo Juliano Oliveira
Summary: The study aimed to formulate a natural fiber-rich food product (NFRFP) for colorectal cancer prevention and evaluate its safety and effects in a preclinical model. Results showed that NFRFP exhibited a chemopreventive effect and reduced the incidence of aberrant crypts in the colon.
Article
Plant Sciences
Kamilla Felipe do Nascimento, Candida Aparecida Leite Kassuya, Marcia Regina Pereira Cabral, Roosevelt Isaias Carvalho Souza, Janaine Alberto Marangoni, Rosilda Mara Mussury Franco Silva, Douglas Alves da Costa Canella, Anelise Samara Nazari Formagio
Summary: The study demonstrated that the hydromethanolic extract of Psidium guineense leaves has antioxidant and anti-inflammatory properties, with no toxicity observed in animals treated acutely or subacutely. This suggests the potential safe traditional use of Psidium guineense.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Elisangela dos Santos, Saulo Euclides Silva-Filho, Joyce Alencar Santos Radai, Arielle Cristina Arena, Thiago Leite Fraga, Claudia Andrea Lima Cardoso, Julio Croda, Candida Aparecida Leite Kassuya
Summary: The ethanolic extract from Vatairea macrocarpa (EEVM) demonstrated anti-inflammatory properties and effectiveness against inflammatory diseases such as rheumatism and rheumatic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Automation & Control Systems
Leandro S. Herculano, Gustavo V. B. Lukasievicz, Elizandra Sehn, Alex S. Torquato, Marcos P. Belancon, Anna P. Simon, Andersson Barison, Maria de Fatima C. Santos, Elton L. Savi, Luis C. Malacarne, Nelson G. C. Astrath
Summary: This study investigates the determination of alcohol concentration in gel-based hand sanitizers using spectroscopic techniques and principal component regression. The results show that this method is fast, low-cost, and safe for determining alcohol concentration in commercial samples.
JOURNAL OF CHEMOMETRICS
(2022)
Article
Reproductive Biology
Beatriz de Matos Manoel, Suyane da Silva Moreira, Gabriela Morelli Zampieri, Luisa Machado Pinheiro, Barbara Campos Jorge, Ana Carolina Casali Reis, Candida Aparecida Leite Kassuya, Arielle Cristina Arena
Summary: This study demonstrates that maternal exposure to tamoxifen can affect reproductive and behavioral parameters in male offspring. Tamoxifen exposure leads to changes in body weight, delayed onset of puberty, and alterations in sperm count and motility in the epididymis.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robson Araujo de Freitas Junior, Paloma Kenia de Moraes Berenguel Lossavaro, Candida Aparecida Leite Kassuya, Edgar Julian Paredes-Gamero, Nelson Carvalho Farias Junior, Maria Ines Lenz Souza, Francielli Maria de Souza Silva-Comar, Roberto Kenji Nakamura Cuman, Denise Brentan Silva, Monica Cristina Toffoli-Kadri, Saulo Euclides Silva-Filho
Summary: This study evaluated the phytochemical profile, oral acute toxicity, and the anti-inflammatory effect of ylang-ylang essential oil. The results showed that ylang-ylang essential oil affected leukocyte activation and had anti-edematogenic, anti-hyperalgesic, and anti-inflammatory properties.
Article
Plant Sciences
Natalia de Matos Balsalobre, Elisangela Dos Santos, Sidney Mariano Dos Santos, Arielle Cristina Arena, Elisabete Castelon Konkiewitz, Edward Benjamin Ziff, Anelise Samara Nazari Formagio, Candida Aparecida Leite Kassuya
Summary: The aim of this study was to investigate the analgesic and anti-arthritic properties of EOAE and viridiflorol using in vivo models.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Silvia Cordeiro das Neves, Flavio Henrique de Araujo, Willian Ayala Correa, Allana Cristina Faustino Martins, Henrique Rodrigues Scherer Coelho, Marcelo Luiz Brandao Vilela, Valter Aragao do Nascimento, Candida Aparecida Leite Kassuya, Denis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira, Roberto da Silva Gomes
Summary: In this study, the genotoxic potential, cell-killing potential, and interactions of phthalide 1 with cyclophosphamide and cisplatin were evaluated. The results showed that 1 increased the frequency of chromosomal damage, cell death, and splenic phagocytosis. The association of 1 with cyclophosphamide and cisplatin demonstrated a chemopreventive effect and reduced the frequency of chromosomal damage.
Article
Pharmacology & Pharmacy
Armando Jorge Junior, Joyce dos Santos Lencina, Elisangela dos Santos, Jonas da Silva Mota, Roberto Kenji Nakamura Cuman, Elisabete Castelon Konkiewitz, Candida Aparecida Leite Kassuya, Saulo Euclides Silva-Filho
Summary: This study demonstrated for the first time the antiarthritic and antinociceptive effects of the ethanolic extract of Piper vicosanum leaves, highlighting its potential clinical applications.
Article
Plant Sciences
Laura Priscila Toledo Bernal, Maicon Matos Leitao, Joyce Alencar Santos Radai, Claudia Andrea Lima Cardoso, Joyce dos Santos Lencina, Thiago Leite Fraga, Arielle Cristina Arena, Saulo Euclides Silva-Filho, Candida Aparecida Leite Kassuya
Summary: This study investigated the analgesic and anti-inflammatory properties of the ethanolic extract from Serjania erecta leaves (EESE) in mice. The results showed that EESE reduced pain response, inhibited leukocyte migration, and decreased neutrophil chemotaxis. Furthermore, EESE exhibited no cytotoxicity in vitro. These findings support the traditional use of S. erecta as a natural analgesic agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Jessica Thais de Lima, Sonia Faria Zawadzki, Frederico Luis Felipe Soares, Kahlil Schwanka Salome, Andersson Barison, Tiago Bueno de Moraes, Caroline Da Ros Montes D'Oca
Summary: Counterfeiting of branded spirits is a growing global problem due to its potential economic gain and the difficulty for consumers to detect counterfeit spirits organoleptically. Apart from the health risks, counterfeit spirits impose financial liability on genuine suppliers and cause revenue loss for governments. The counterfeiting process involves refilling brand spirit bottles with cheaper alternatives or counterfeits and resealing them with authentic bottle caps, leaving behind traces that can be used for identification. Infrared Spectroscopy and Time-Domain Nuclear Magnetic Resonance are effective tools for detecting counterfeit spirits based on the analysis of bottle caps.
MICROCHEMICAL JOURNAL
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)