Review
Biochemistry & Molecular Biology
Rola A. Bekdash
Summary: Neurodegenerative diseases, particularly Alzheimer's disease, are associated with dysregulation of cholinergic and adrenergic signaling systems, leading to the degeneration of specific neurons. Understanding and targeting these systems may have therapeutic implications for treating Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
N. L. Taylor, A. D'Souza, B. R. Munn, J. Lv, L. Zaborszky, E. J. Muller, G. Wainstein, F. Calamante, J. M. Shine
Summary: Complex cognitive abilities are believed to come from the brain's ability to reconfigure its internal network structure in response to task demands. Recent research suggests that this flexibility is partly due to the widespread projections of the ascending arousal systems. This study found that the strength of structural connectivity between the noradrenergic and cholinergic arousal systems is related to the dynamic features of functional integration in the brain, indicating the crucial role of anatomical connections in mediating adaptive network dynamics.
Article
Behavioral Sciences
F. Krohn, E. Lancini, M. Ludwig, M. Leiman, G. Guruprasath, L. Haag, J. Panczyszyn, E. Duezel, D. Haemmerer, M. Betts
Summary: The locus coeruleus (LC), a small structure in the brainstem, is the main source of noradrenaline (NA) in the brain. It modulates cognition, autonomic functions, and the brain's immune response. Degeneration of the LC may contribute to the pathogenesis of Alzheimer's and Parkinson's disease. Understanding early LC degeneration could provide insights into the mechanisms of these neurodegenerative diseases.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Shahryar Noei, Ioannis S. Zouridis, Nikos K. Logothetis, Stefano Panzeri, Nelson K. Totah
Summary: The noradrenergic locus coeruleus (LC) plays a crucial role in controlling brain and behavioral states. It has been found that different ensembles of spontaneously coactive LC neurons could lead to diverse cortical states, with some showing high-frequency power increase and others showing decreased high-frequency power.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Robert A. Morrison, Stephanie T. Abe, Tanya Danaphongse, Vikram Ezhil, Armaan Somaney, Katherine S. Adcock, Robert L. Rennaker, Michael P. Kilgard, Seth A. Hays
Summary: Vagus nerve stimulation (VNS) enhances synaptic plasticity during motor rehabilitation, and common pharmaceuticals at clinically relevant doses are unlikely to negatively impact the efficacy of VNS therapy.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Xiaojing Zhai, Dongyu Zhou, Yi Han, Ming-Hu Han, Hongxing Zhang
Summary: Resilience is an active adaption process in response to adversity, trauma, tragedy, threats, or stress. The neurobiological mechanisms of resilience have provided new insights for preclinical research and drug development for stress-related disorders. The locus coeruleus norepinephrine system plays a key role in mediating stress susceptibility versus resilience and has gained significant attention in recent years. This review article discusses resilience-related concepts, rodent paradigms for studying susceptibility and resilience, recent findings on neuronal and molecular substrates of active resilience in the locus coeruleus, and potential future directions for resilience research.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biology
Juan Carlos Cerpa, Alessandro Piccin, Margot Dehove, Marina Lavigne, Eric J. Kremer, Mathieu Wolff, Shauna L. Parkes, Etienne Coutureau
Summary: Organisms need to track the relationship between actions and consequences in order to make decisions, which relies on circuits in the brain. There is functional heterogeneity within certain areas of the brain in rodents. Neuromodulatory agents play a crucial role in prefrontal functions and behavioral flexibility.
Article
Neurosciences
Theodoros Tsetsenis, Julia K. Badyna, Rebecca Li, John A. Dani
Summary: Processing of contextual information is crucial for learning and memory. This study demonstrates that increasing noradrenergic activity in the hippocampus enhances contextual associative learning, and this effect requires activation of specific receptors. Additionally, it shows that increasing norepinephrine release can ameliorate contextual fear learning impairments caused by dopaminergic dysregulation in the hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yuxiao Zhang, Yan Chen, Yushi Xin, Beibei Peng, Shuai Liu
Summary: Reward learning is crucial for survival and attention plays a key role in the recognition of reward cues and formation of reward memories. However, the neurological processes of the interaction between reward and attention are not well understood due to the diverse neural substrates involved in these processes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Anthony M. Downs, Zoe A. McElligott
Summary: This review discusses recent advances in understanding the role of the noradrenergic system in substance use disorders, including potential therapeutic targets and new treatment approaches.
Article
Clinical Neurology
Michael A. Urbin, Charles W. Lafe, Tyler W. Simpson, George F. Wittenberg, Bharath Chandrasekaran, Douglas J. Weber
Summary: The study investigated the acute pupillary responses elicited by transcutaneous stimulation of the external ear, finding that stimulation at different locations can provoke such responses, with effects influenced by pulse amplitude and frequency. Further research is needed to distinguish the roles of vagal and non-vagal afferents in mediating biomarker activation.
Article
Endocrinology & Metabolism
Agustin Benitez, Raul Riquelme, Miguel del Campo, Camila Araya, Hernan E. Lara
Summary: The study finds that NGF may be one of the main regulators of the ovary, suggesting its role in the cholinergic system of the ovary as well.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Behavioral Sciences
Isabella F. Orlando, James M. Shine, Trevor W. Robbins, James B. Rowe, Claire O'Callaghan
Summary: Noradrenergic and cholinergic systems play a crucial role in neuropsychiatric diseases of aging like Alzheimer's disease and Parkinson's disease. However, their contribution to symptoms is not well understood, and pharmacological interventions targeting these systems have had mixed success. This review addresses these challenges, outlining the roles of these systems in cognition and behavior and discussing their influence on neuropsychiatric symptoms in disease. Bridging across levels of analysis, the review emphasizes opportunities for improving drug therapies and personalized medicine strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Oncology
Cody Slater, Qi Wang
Summary: Alzheimer's disease is a significant global health issue with no disease-altering therapy achieved yet, but research shows dysfunction in the noradrenergic system plays an important role in the pathogenesis and symptomatic exacerbation of the disease. The imbalance between noradrenergic and cholinergic systems is involved in AD, with potential for treatment using neural stimulation techniques.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alejandro Osorio-Forero, Romain Cardis, Gil Vantomme, Aurelie Guillaume-Gentil, Georgia Katsioudi, Christiane Devenoges, Laura M. J. Fernandez, Anita Luthi
Summary: During NREMS, fluctuation of noradrenaline levels in thalamus are associated with sleep spindle rhythms and heart-rate variations, indicating vigilance-promoting mechanism by LC neurons. Optogenetic activation or inhibition of LC neurons can modulate sleep-spindle clustering and heart-rate variations, affecting sensory arousability during NREMS. Noradrenergic modulation of thalamic circuits plays a key role in maintaining sensory arousability in mammalian NREMS.
Article
Computer Science, Artificial Intelligence
Enhao Zheng, Jingeng Mai, Yuxiang Liu, Qining Wang
FRONTIERS IN NEUROROBOTICS
(2018)
Article
Neurosciences
Charles Rodenkirch, Yang Liu, Brian J. Schriver, Qi Wang
NATURE NEUROSCIENCE
(2019)
Article
Engineering, Biomedical
Charles Rodenkirch, Qi Wang
JOURNAL OF NEURAL ENGINEERING
(2020)
Article
Psychology, Biological
Brian J. Schriver, Sean M. Perkins, Paul Sajda, Qi Wang
Article
Neurosciences
Yuxiang Liu, Shreya Narasimhan, Brian J. Schriver, Qi Wang
Summary: This study found that pupil size and heart rate were correlated with behavioral outcomes in rats, and the use of both as inputs allowed for better prediction of behavior, indicating that the effects of the two arousal systems on behavior are not completely redundant.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2021)
Review
Oncology
Cody Slater, Qi Wang
Summary: Alzheimer's disease is a significant global health issue with no disease-altering therapy achieved yet, but research shows dysfunction in the noradrenergic system plays an important role in the pathogenesis and symptomatic exacerbation of the disease. The imbalance between noradrenergic and cholinergic systems is involved in AD, with potential for treatment using neural stimulation techniques.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Pawan Lapborisuth, Sharath Koorathota, Qi Wang, Paul Sajda
Summary: This study utilized virtual reality (VR) technology to investigate the relationship between gaze and attention reorienting, finding that gaze dwell time contributed most significantly to reorienting signals. By integrating EEG, pupil, and dwell time features, a hybrid classifier successfully detected reorienting signals in both fixed and free conditions.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Biology
Evan Weiss, Michael Kann, Qi Wang
Summary: Over the past few decades, advancements in EEG recordings and brain stimulation have provided insights into how specific brain structures communicate and organize complex cognitive functions. Neurotransmitters such as norepinephrine, acetylcholine, and dopamine have been shown to impact neural oscillations and cognitive functions. Cross-frequency coupling (CFC) in neurological disorders highlights the crucial role of neurotransmitters in coordinating healthy brain function.