Article
Biochemistry & Molecular Biology
Wenjun Miao, Rong Huang, Xiaoli Huang, Fei Gao, Xiangpeng Leng, Qiu Li
Summary: In this study, polysaccharides from grape pomace (GPPs) were characterized and evaluated. GPPs were found to be heteropolysaccharides rich in arabinose, galactose, and glucuronic acid, with irregular clusters on the surface. In vitro assays showed concentration-dependent antioxidant activity of GPPs. In vivo experiments demonstrated that GPPs decreased levels of inflammatory markers and oxidative stress indicators, while increasing levels of antioxidant enzymes in serum and liver tissues. The histopathological examination further confirmed the hepatoprotective effects of GPPs.
Article
Biochemistry & Molecular Biology
Huifan Liu, Yuke Fang, Yanfu Li, Lukai Ma, Qin Wang, Gengsheng Xiao, Cuiyun Zou
Summary: PCS-2A is an acidic polysaccharide purified from chestnut shell with a molecular weight of 34,023 Da, containing various sugar units in specific ratios. It shows potential in protecting liver cells from H2O2-induced injury through activation of the NRF2 signaling pathway, reducing oxidative stress and inflammatory response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Fei Gao, Huimin Liu, Hao Han, Xin Wang, Lihua Qu, Congmin Liu, Xuemei Tian, Ranran Hou
Summary: In this study, BRP-selenium nanoparticles (BRP-SeNPs) were prepared using Berberidis radix polysaccharide (BRP) as capping agents, and their properties and pharmacological functions were investigated. The results showed that BRP-SeNPs exhibited hepatoprotective effects and attenuated oxidative stress and inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yihua Huang, Yi Gao, Xionge Pi, Shuang Zhao, Wei Liu
Summary: This study determined the composition of polysaccharide-peptides from Pleurotus citrinopileatus and investigated their protective effects on liver and gut microbiota. The polysaccharide-peptides showed hepatoprotective effects, reduced lipid accumulation, and influenced the relative abundances of gut bacteria. The findings suggest that polysaccharide-peptides may play a role through the liver-gut axis system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Fang Zhang, Xia Zhang, Yutian Gu, Min Wang, Sheng Guo, Jiazheng Liu, Xiaofei Zhang, Zihan Zhao, Bowen Qian, Yichao Yan, Li Yu, Chunlei Xu, Chunmei Liu, Funing Cao, Dawei Qian, Jin-ao Duan
Summary: Natural polysaccharide LFP-a1 isolated from Lycii fructus showed hepatoprotective effects in NAFLD models by regulating oxidative stress and apoptotic pathways, indicating its potential as a therapeutic agent for liver diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Rositsa Mihaylova, Reneta Gevrenova, Alexandra Stefanova, Dimitrina Zheleva-Dimitrova, Vessela Balabanova, Gokhan Zengin, Rumyana Simeonova, Georgi Momekov
Summary: Oxidative stress is a common phenomenon in liver disorders and it affects patient survival and drug effectiveness. In this study, the antioxidant and hepatoprotective activities of the Prenanthes purpurea extract were investigated. The extract contains various secondary metabolites, including quinic acid and flavonoids, which contribute to its hepatoprotective activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Jing-Kun Yan, Chun Wang, Ting -Ting Chen, Jie Zhu, Xu Chen, Longqing Li, Xiaozhen Liu, Henan Zhang, Lin Li
Summary: This study demonstrated the hepatoprotective potential of pectic polysaccharide OPS-50 from fresh okra pods in mice with acute liver damage. OPS-50 showed positive effects in relieving weight reduction, organ damage, liver function and dyslipidemia, oxidative stress, pro-inflammatory cytokines, gut microbiota modulation, and short-chain fatty acid secretion. The histopathology of the liver also supported the protective benefit of OPS-50.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: 18-β-Glycyrrhetinic acid has promising hepatoprotective effects against cholestatic liver injury, improving liver histology and reducing oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis.
Article
Pharmacology & Pharmacy
Fahad S. Alshehri, Nasser M. Alorfi
Summary: Vancomycin has a high risk of causing liver injury, but resveratrol can protect the liver from its toxicity. The study showed that co-treatment with resveratrol prevented the elevation of liver damage markers and the depletion of antioxidants caused by vancomycin. In addition, resveratrol prevented the degeneration of liver cells induced by vancomycin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenshuai Wang, Yaohan Zhang, Xinchao Liu, Zonghui Liu, Le Jia, Jianjun Zhang
Summary: The present study aimed to investigate the hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). The results demonstrated that RPS showed significant protection against carbon tetrachloride (CCl4)-induced liver injury. The possible mechanisms included anti-oxidation, anti-inflammation, anti-apoptosis, and anti-fibrosis effects. These findings suggested that RPS could be used as a promising diet supplement or medication for hepatic diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Zuoxu Hou, Xiao Wang, Zefeng Yang, Zhiwei Deng, Jin Zhang, Jintao Zhong, Shanrui Liu, Yuanyuan Hu, Hongxun Sang
Summary: Plant-derived exosome-like nanovesicles from pomegranate (PENs) demonstrated therapeutic potential for nonalcoholic fatty liver disease (NAFLD) by improving mitochondrial function and reducing lipid accumulation. In cell experiments, PENs were internalized by HepG2 cells and ameliorated palmitic acid-induced lipid accumulation and mitochondrial dysfunction. In mouse experiments, oral administration of PENs accumulated in the liver and effectively alleviated NAFLD induced by high-fat diet, with improvements in mitochondrial function and antioxidant capacity. These findings provide new mechanistic insights into pomegranate's hepatoprotective effects and highlight the therapeutic potential of PENs for NAFLD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Mohammad Hadi Baghersad, Ali Maleki, Mohammad Reza Khodabakhshi
Summary: Increasing population growth and rapid industrialization have led to severe environmental pollution. This study focused on the synthesis of a biopolymeric texture nano adsorbent for the removal of environmental pollutants. The results showed that the nanocomposite had a spherical structure and high adsorption capacity. Additionally, it did not exhibit antibacterial activity against E. coli and S. aureus.
JOURNAL OF CONTAMINANT HYDROLOGY
(2023)
Article
Medicine, Research & Experimental
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: Plumbagin has the potential to protect the liver from cholestatic damage by regulating multiple intracellular signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Food Science & Technology
Li Chen, Jingjing Liu, Guibin Mei, Huimin Chen, Shufen Peng, Ying Zhao, Ping Yao, Yuhan Tang
Summary: Quercetin, a polyphenol found in plants, has shown hepatoprotective effects against NAFLD, particularly in hepatic steatosis and hepatitis, through mechanisms such as improving fatty acid metabolism and anti-inflammation. Further research based on GEO database and experimental evidence has discussed the pathways of quercetin on NAFLD comprehensively.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lili Huang, Haiyan Zhu, Yuqin Tang, Zheng Luo, Luyun Xia, Chunjiang Zhang, Yanqiu Wang, Wenying Huai, Zhiyan Fang, Shenrong Li, Zhiyong Yan, Qiaozhi Yin, Tian-e Zhang
Summary: This study explored the regulatory mechanism of Cassiae semen (CS) on lipid metabolism in non-alcoholic fatty liver disease (NAFLD) using network pharmacology and in vitro experiments.
BIOSCIENCE REPORTS
(2023)
Review
Allergy
Rundong Qin, Li He, Zhaowei Yang, Nan Jia, Ruchong Chen, Jiaxing Xie, Wanyi Fu, Hao Chen, Xinliu Lin, Renbin Huang, Tian Luo, Yukai Liu, Siyang Yao, Mei Jiang, Jing Li
Summary: Abnormal immunological indicators are associated with disease severity and mortality in patients with COVID-19. This meta-analysis synthesized the findings of many studies and found that cytokine levels, white blood cell count, and inflammatory markers were significantly increased in severely ill patients or non-survivors. Conversely, lymphocyte count, monocyte count, and other indicators were significantly increased in non-severely ill patients or survivors. Impaired immune response and increased inflammation, coagulation dysfunction, and nonpulmonary organ injury were marked features of patients with poor prognosis. Parameters of immune response dysfunction combined with inflammatory, coagulated, or nonpulmonary organ injury indicators may be more sensitive to predict severe patients and non-survivors.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Economics
Ren Huang, Sufang Zhang, Peng Wang
Summary: The article evaluates the key areas and pathways for carbon emissions reduction in Beijing from 2015 to 2060 using extended STIRPAT model and LEAP-Beijing model. It highlights that energy structure upgrading and energy efficiency improvement are crucial for the city's emissions reduction. Achieving the Dual-Carbon targets requires a low-carbon transition across all sectors, with prioritization on power, transportation, and commercial sectors.
Correction
Chemistry, Medicinal
Ling Wei, Shujuan Lv, Quanfang Huang, Jinbin Wei, Shijun Zhang, Renbin Huang, Zhongpeng Lu, Xing Lin
Article
Energy & Fuels
Tianyu Cao, WooJae Lee, Renjing Huang, Raymond J. Gorte, John M. Vohs
Summary: The cyclic molecule 1,2,3,4-tetrahydroquinoline (THQ) has been examined as a liquid-organic hydrogen carrier (LOHC) for endothermic fuel in hypersonic aircraft engines. It showed high conversion rates and stability, making it a potential alternative for endothermic cooling.
Article
Chemistry, Physical
Ohhun Kwon, Alexandre C. Foucher, Renjing Huang, Eric A. Stach, John M. Vohs, Raymond J. Gorte
Summary: LaMnO3 films with a thickness of 0.5 nm were successfully deposited on CaO-modified γ-Al2O3 substrate using atomic layer deposition (ALD) method. The presence of CaO effectively prevented the formation of LaAlO3 when depositing La2O3 directly onto γ-Al2O3. The LaMnO3 films exhibited two-dimensional crystallites with a size of approximately 10-15 nm. At high temperatures, oxidation caused Ni to spread over the LaMnO3 film, while the Ni formed by high-temperature reduction remained well dispersed and showed higher activity for CO2 reforming of CH4 compared to Ni on MgAl2O4. These results have important implications for understanding the metal-support interactions between Ni and LaMnO3.
JOURNAL OF CATALYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Jiazhu Qin, Manala Mazomba, Renwei Huang, Jiating Zhao, Faxing Wang, Gangjian He, Jue Wang, Wenwen Du, Yunchang Mo
Summary: This study investigated the relationship between typhoon, climate change, and acute Stanford type A aortic dissection (TAAD) in southern Zhejiang Province, China. The findings suggest that TAAD incidence is highest in winter and lowest in summer. Maximum wind speed and water vapor pressure may serve as protective factors.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Plant Sciences
Huamin Liu, Shiqi Xiao, Shunzhao Sui, Renwei Huang, Xia Wang, Huafeng Wu, Xia Liu
Summary: The study identified a CCCH type zinc finger protein gene CpC3H3 from wintersweet, which plays a crucial role in flowering inducement and drought tolerance in transgenic Arabidopsis thaliana. This gene has the potential to be utilized for promoting flowering and enhancing drought tolerance in plants.
Article
Environmental Sciences
Hui Ren, Renhua Huang, Ying Li, Wanting Li, Liuliu Zheng, Yanbao Lei, Ke Chen
Summary: This study investigated the regulation mechanism of moss photosynthesis under strontium pollution. The results showed that moderate and high levels of Sr2+ stress triggered oxidative stress responses and photo-damage, while low levels of Sr2+ stress resulted in photosynthetic acclimation. These regulation mechanisms mainly involve the regulation of reactive oxygen species, activation of photo-inhibition and photo-protective mechanisms in photosystem I and photosystem II, as well as adjustments in flavodiiron proteins and cyclic electron flow.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Organic
Yongzheng Ding, Renbin Huang, Wei Zhang, Hanmin Huang
Summary: A catalytic system combining NiBr2 and diphenylphosphine oxide was developed for the direct synthesis of valuable arylacetic acids from inexpensive alkylarenes and H2O via oxidative carbonylation. This method is compatible with alkylarenes containing primary and secondary benzylic C-H bonds, and the commonly used drugs ibuprofen and diclofenac can be easily obtained.
Article
Metallurgy & Metallurgical Engineering
Guo Wei, Chen Xue-yuan, Ye Yi-tao, Hu Yao, Luo Yi-kai, Shao Ping, Huang Ren-qiang, Wang Xu-yixin, Guo Zhen, Tan Sui
Summary: The failure of the control loop in a high-speed maglev train running on a viaduct can lead to collisions between the train and the track due to the failure of the levitation magnets. A model that couples the maglev train and the viaduct is established to study the dynamic response under control loop failures, and the most disadvantageous combination of failures is obtained. The results show that single control loop failures do not lead to collisions, but there is a risk of rail collisions when both control loops fail.
JOURNAL OF CENTRAL SOUTH UNIVERSITY
(2022)
Article
Biotechnology & Applied Microbiology
Jun-Yi Xiang, Xiao-Shan Huang, Jian-Xia Xu, Ren-Hua Huang, Xiao-Zhong Zheng, Li-Ming Xue, Yu-Long Liu
Summary: This study compared the accuracy of MRI, Partin tables, MSKCCn, and combined models in predicting extraprostatic extension (EPE) in prostate cancer and analyzed the clinical value of EPE grade. The results showed that combining EPE grade with Partin tables and MSKCCn significantly improved the diagnostic efficiency of the clinical model and increased the clinical benefit.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Xingchun Wu, Xing Zhou, Yong Huang, Luhui Qin, Shunyu Lu, Yani Wu, Xiaolin Zhang, Liping Zhong, Yongxiang Zhao, Renbin Huang, Yuhuan Wang
Summary: This study explores the activity and mechanism of DMDD against liver cancer, demonstrating its inhibitory effects on cell proliferation, migration, and invasion and its ability to induce apoptosis and cell cycle arrest. DMDD effectively suppresses the growth of liver cancer and downregulates the expression of IL-2, IL-4, and IL-10. It also exhibits significant apoptosis-inducing effects on liver cancer cells in mice, possibly through modulation of the MAPK pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Correction
Engineering, Environmental
Hailu Fu, Jilei Lin, Shuang Cao, Bosheng Chen, Renhua Huang, Hao Chen, Tao Ding, Pengfei Sun, Ligang Luo
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Engineering, Environmental
Yuhui Deng, Peng Gao, Lu Wang, Yongqing Zhang, Juncong Fu, Renfeng Huang, Shuaifei Zhao, Guangzhao Wang, Yuancheng Wei, Shaoqi Zhou
Summary: Recent studies have shown that the introduction of oxygen vacancies in MnO2 materials can greatly enhance the adsorption capacity of the material for PMS, leading to the formation of more favorable reactive complexes in the electron transfer mechanism. Additionally, the V-o-MnO2/PMS system has significantly improved the degradation efficiency of pollutants, highlighting the important role of oxygen vacancies in the electron transfer mechanism and providing a new method for practical application in wastewater treatment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Hematology
Xiao-Lu Zhu, Ru Feng, Qiu-Sha Huang, Mei-Ying Liang, Ming Jiang, Hui Liu, Yi Liu, Hong-Xia Yao, Lei Zhang, Shen-Xian Qian, Tong-Hua Yang, Jing-Yu Zhang, Xu-Liang Shen, Lin-Hua Yang, Jian-Da Hu, Ren-Wei Huang, Zhong-Xing Jiang, Jing-Wen Wang, Hong-Yu Zhang, Zhen Xiao, Si-Yan Zhan, Hui-Xin Liu, Xing-Lin Wang, Ying-Jun Chang, Yu Wang, Yuan Kong, Lan-Ping Xu, Kai-Yan Liu, Xiao-Hong Zhang, Cheng-Hong Yin, Yue-Ying Li, Qian-Fei Wang, Jian-Liu Wang, Xiao-Jun Huang, Xiao-Hui Zhang
Summary: This study evaluated the safety and effectiveness of prednisone plus IVIg in pregnant patients with immune thrombocytopenia (ITP). The combination therapy showed a shorter time to response and duration of treatment compared to prednisone monotherapy. Additionally, the combination therapy had a lower predelivery platelet transfusion rate compared to IVIg alone.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)