Review
Biochemistry & Molecular Biology
Nikolaos Machairiotis, Sofia Vasilakaki, Nikolaos Thomakos
Summary: Inflammatory mediators play a crucial role in inducing pain in endometriosis. Inhibition of the synthesis of these mediators may provide an effective treatment for inflammation-induced pain in endometriosis. Identifying and targeting these mediators could lead to the development of novel treatments for chronic pelvic pain in endometriosis patients.
Review
Virology
Tony J. F. Guo, Gurpreet K. Singhera, Janice M. Leung, Delbert R. Dorscheid
Summary: The airway epithelium plays a crucial role in the defense and immune response of the lungs against COVID-19. Severe COVID-19 is characterized by an excessive inflammatory response, which can lead to lung injury and organ failure. The immune response of the airway epithelium to SARS-CoV-2 infection may contribute to the pathogenesis of severe COVID-19. This article reviews the barrier and immune functions of the airway epithelium, the interaction between SARS-CoV-2 and the epithelium, and the role of epithelial-derived cytokines and chemokines in COVID-19 as well as their potential as biomarkers and therapeutic targets.
Review
Biochemistry & Molecular Biology
Tibor Docsa, Adam Sipos, Charles S. Cox, Karen Uray
Summary: Feeding intolerance and ileus are common complications in critically ill, surgical, and trauma patients, leading to longer hospital stays, increased infections, readmission rates, and medical costs. Current medical treatment for ileus is ineffective and has serious side effects. Inflammatory mediators play a critical role in the development of ileus, but their direct effects on gastrointestinal cells are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Panagiotis Theofilis, Marios Sagris, Alexios S. Antonopoulos, Evangelos Oikonomou, Costas Tsioufis, Dimitris Tousoulis
Summary: In the context of dysfunctional vascular endothelium, platelet activation occurs due to structural alterations like endothelial glycocalyx thinning or functional modifications through impaired NO bioavailability. Additionally, neutrophil-derived mediators and neutrophil extracellular traps formation contribute to platelet activation and platelet-leukocyte aggregation. Pro-inflammatory cytokines and their receptors in platelets, along with factors like TNF-alpha, play critical roles in inducing inflammatory responses and affecting platelet activation. Furthermore, new concepts linking inflammation and platelet activation, such as toll-like receptors, myeloperoxidase, and platelet factor-4, have been explored. The evidence is particularly relevant in the context of COVID-19, where excessive inflammation leads to thrombotic complications partially mediated by platelet activation. Advances in anti-inflammatory therapies have shown promise in reducing platelet activation and its thrombotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Patrick Schaedel, Fabiana Troisi, Anna Czapka, Nadja Gebert, Simona Pace, Alessandro Ori, Oliver Werz
Summary: Aging is often accompanied by chronic systemic inflammation, referred to as inflammaging, which plays a major role in age-associated diseases. Research shows that different organs have organ-specific responses to inflammatory cytokines, chemokines, and lipid mediators, with varying levels of pro-inflammatory and pro-resolving mediators during the aging process.
Article
Immunology
Olubukola Titilope Oyebode, John Oludele Olanlokun, Olamilekan Salami, Ifeanyi Obi, Olusola Bodede, Gerhard Prinsloo, Olufunso Olabode Olorunsogo
Summary: The study compared the efficacy of terpene-rich fractions of F. mucoso root bark on LPS-induced inflammation and mitochondrial health, finding that TRDF was more effective in reducing cytokine levels and improving liver mitochondrial permeability transition compared to TREF. These results suggest that TRDF is a promising anti-inflammatory compound for LPS-induced acute systemic inflammation.
INFLAMMOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Salvatore Calogero Gaglio, Marta Donini, Piyachat Evelyn Denbaes, Stefano Dusi, Massimiliano Perduca
Summary: Oxyresveratrol suppresses cytokine production by activated dendritic cells and when loaded into poly(lactic-co-glycolic acid) nanoparticles, it mitigates the pro-inflammatory effects. This suggests that oxyresveratrol could serve as a promising anti-inflammatory and immune-suppressive agent.
Review
Plant Sciences
Gopalsamy Rajiv Gandhi, Poovathumkal James Antony, Maria Julia Miranda de Paula Lana, Brenda Fernandes Xavier da Silva, Roberta Vieira Oliveira, Gnanasekaran Jothi, Govindasamy Hariharan, Thiruchenduran Mohana, Ren-You Gan, Ricardo Queiroz Gurgel, Rosana Cipolotti, Lucindo Jose Quintana Junior
Summary: This study systematically reviewed the potential of natural products in regulating cancer-related signaling pathways, showing their ability to weaken pro-and anti-inflammatory signaling markers. Flavonoids, polyphenols, polysaccharides, alkaloids, and tannins are believed to play important roles in cancer modulation.
Article
Biochemistry & Molecular Biology
Makram Merimi, Karolien Buyl, Dhouha Daassi, Robim M. Rodrigues, Rahma Melki, Philippe Lewalle, Tamara Vanhaecke, Hassan Fahmi, Vera Rogiers, Laurence Lagneaux, Joery De Kock, Mehdi Najar
Summary: This study investigates the response of AT-MSCs to inflammation and cell-passaging, revealing that inflammation leads to upregulation of specific cytokines and TLR, while cell-passaging increases the expression of other genes. These findings provide insights into the characteristics of AT-MSCs and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Niluni M. Wijesundara, Song F. Lee, Ross Davidson, Zhenyu Cheng, H. P. Vasantha Rupasinghe
Summary: The study found that carvacrol has anti-inflammatory properties and may be used to manage the pain associated with streptococcal pharyngitis.
Article
Immunology
Ben A. A. Calvert, Erik J. J. Quiroz, Zareeb Lorenzana, Ngan Doan, Seongjae Kim, Christiana N. N. Senger, Jeffrey J. J. Anders, Wiliam D. D. Wallace, Matthew P. P. Salomon, Jill Henley, Amy L. L. Ryan
Summary: Neutrophils play a crucial role in the innate immune response against viral infection. Chronic airway neutrophilia is associated with severe COVID-19 cases. COVID-19 infection leads to epithelial pathologies and the activation of neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Madlen Reinicke, Judith Leyh, Silke Zimmermann, Soroth Chey, Ilijana Begcevic Brkovic, Christin Wassermann, Julia Landmann, Dieter Luetjohann, Berend Isermann, Ingo Bechmann, Uta Ceglarek
Summary: Plant sterols (PSs) must be obtained through diet as mammals cannot synthesize them. Obesity induced by a high-fat diet leads to decreased levels of PSs in the blood and brain, which have anti-neuroinflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Henry Velazquez-Soto, Sergio Groman-Lupa, Marisa Cruz-Aguilar, Alberto L. Salazar, Juan C. Zenteno, Maria C. Jimenez-Martinez
Summary: Age-related macular degeneration (AMD) is a complex retinal disease that results in progressive irreversible degeneration of photoreceptors. Oxidative stress, chronic inflammation, and genetic factors, such as the CFH Y402H polymorphism, contribute to AMD pathogenesis. In this study, it was found that ARPE-19 cells with the CFH Y402H variant were more susceptible to oxidative stress-induced damage and exhibited increased levels of inflammatory mediators and pro-apoptotic factors. However, pretreatment with exogenous CFH protected the cells from damage and cell death, possibly through negative regulation of pro-inflammatory cytokines.
Article
Cell Biology
Faezeh Niazi Shahraki, Saeideh Momtaz, Maryam Baeeri, Danial Khayatan, Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Ali Reza Abdollahi, Ahmad Reza Dehpour, Amir Hossein Abdolghaffari
Summary: This study evaluated the anti-inflammatory effects of Licofelone in a rat model of acetic acid-induced colitis. The results showed that Licofelone attenuated colitis, increased superoxide dismutase activity, and significantly reduced colonic levels of inflammatory factors. Additionally, the concurrent use of nitric oxide synthase inhibitors with Licofelone reversed the observed positive effects, demonstrating the role of nitric oxide in the pathogenesis of inflammatory bowel disease and the mechanism of action of Licofelone in colitis healing.
Review
Immunology
M. Fathimath Muneesa, Sadiya B. Shaikh, T. M. Jeena, Yashodhar P. Bhandary
Summary: Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease characterized by lung tissue scarring leading to respiratory failure. The exact etiology of the disease is unclear and the role of inflammation in its development is controversial. Inflammatory cytokines play a critical role in initiating the inflammatory response in the lungs, contributing to the pathogenesis of IPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Applied
Mary H. Grace, Jia Xiong, Debora Esposito, Mark Ehlenfeldt, Mary Ann Lila
Article
Agriculture, Dairy & Animal Science
Kathleen R. Walter, Xi Lin, Sheila K. Jacobi, Tobias Kaser, Debora Esposito, Jack Odle
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Debora Esposito, John Overall, Mary H. Grace, Slavko Komarnytsky, Mary Ann Lila
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Plant Sciences
Rong Di, Anne F. Murray, Jia Xiong, Debora Esposito, Slavko Komarnytsky, Thomas J. Gianfagna, John P. Munafo
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Editorial Material
Pharmacology & Pharmacy
Namrita Lall, Mohamad Fawzi Mahomoodally, Debora Esposito, Vanessa Steenkamp, Gokhan Zengin, Aimee Steyn, Carel B. Oosthuizen
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Cell Biology
Barbara Cristina Felix Nogueira, Artur Kanadani Campos, Raul Santos Alves, Mariaurea Matias Sarandy, Romulo Dias Novaes, Debora Esposito, Reggiani Vilela Goncalves
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Editorial Material
Cell Biology
Reggiani Vilela Goncalves, Mariaurea Matias Sarandy, Debora Esposito, Maria do Carmo Gouveia Peluzio
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Food Science & Technology
Larissa Marina Pereira Silva, Maria Raquel Cavalcanti Inacio, Gualter Guenter Costa da Silva, Jucier Magson de Souza e Silva, Jefferson Romaryo Duarte da Luz, Maria das Gracas Almeida, Edgar Perin Moraes, Debora Esposito, Leandro De Santis Ferreira, Silvana Maria Zucolotto
Summary: Moringa oleifera leaves are rich in flavonoids, and the highest flavonoid content can be obtained through ultrasound-assisted extraction. The optimal cultivation condition is using mineral soil fertilizer in the drought season, with the optimized extraction conditions being 80% ethanol and 13.4 minutes extraction time. The extract is safe and significantly reduces inflammation, with major compounds derived from apigenin, quercetin, and kaempferol glycosides.
Article
Medicine, Research & Experimental
Jia Xiong, Sierra Bonney, Reggiani Vilela Goncalves, Debora Esposito
Summary: In this study, the effects of BRs on wound repair were analyzed. It was found that certain BRs compounds can reduce inflammation and promote migration of skin cells. Furthermore, BRs have positive effects on mitochondrial metabolism, contributing to skin health.
Editorial Material
Cell Biology
Reggiani Vilela Goncalves, Mariella Bontempo Freitas, Debora Esposito
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Edilane Rodrigues Dantas Araujo, Jacinthia Beatriz Xavier-Santos, Valeria Costa da Silva, Juliana Bessa Figueiredo de Lima, Jade Schlamb, Matheus de Freitas Fernandes-Pedrosa, Arnobio Antonio da Silva Junior, Raimundo Fernandes de Araujo Junior, Thirumurugan Rathinasabapathy, Marvin Moncada, Debora Esposito, Gerlane Coelho Bernardo Guerra, Silvana Maria Zucolotto
Summary: This study evaluated the stability and healing effects of a gel formulation containing Bryophyllum pinnatum leaf extract on skin wounds. The results showed that the gel formulation stimulated wound healing, reduced inflammation, and promoted angiogenesis. Therefore, it has the potential to be used as an active ingredient in wound healing pharmaceuticals.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elaine Cristine Souza da Silva, Gerlane Coelho Bernardo Guerra, Edilane Rodrigues Dantas de Araujo, Jade Schlamb, Valeria Costa da Silva, Emanuella de Aragao Tavares, Renato Dantas-Medeiros, Lucas Silva Abreu, Josean Fechine Tavares, Raimundo Fernandes de Araujo Junior, Debora Esposito, Marvin Moncada, Silvana Maria Zucolotto
Summary: Nopalea cochenillifera, native to Mexico but widely introduced in Brazil, has been used as food and medicine due to its high content of phenolic compounds. The study evaluated the phytochemical profile and gastroprotective activity of a phenolic-rich extract from N. cochenillifera in gastric lesion models. The extract showed promising results in reducing gastric lesions and restoring gastric health.
Article
Biochemistry & Molecular Biology
Jia Xiong, Fernanda Matta, Mary Grace, Mary Ann Lila, Neil L. Ward, Monica Felipe-Sotelo, Debora Esposito