Advances in plant-based inhibitors of P-glycoprotein

P-glycoprotein in autoimmune rheumatic diseases

(2015) M. García-Carrasco et al.   AUTOIMMUNITY REVIEWS

Disposition of Flavonoids Impacts their Efficacy and Safety

(2015) Yong Ma et al.   CURRENT DRUG METABOLISM

P-Glycoprotein Mediated Drug Interactions in Animals and Humans with Cancer

(2015) K.L. Mealey et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells

(2015) Grégory Gatouillat et al.   PHYTOMEDICINE

Recent trends in preclinical drug-drug interaction studies of flavonoids - Review of case studies, issues and perspectives

(2015) Nuggehally R. Srinivas   PHYTOTHERAPY RESEARCH

P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

(2015) Hossam M. Abdallah et al.   Journal of Advanced Research

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

(2014) Yue-Hu Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation

(2014) Yuhua Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

The effects of human immunodeficiency virus infection on the expression of the drug efflux proteins P-glycoprotein and breast cancer resistance protein in a human intestine model

(2014) Kelstan Ellis et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells

(2014) Yan Fang Sun et al.   PHYTOMEDICINE

Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats

(2014) Liyue Huang et al.   XENOBIOTICA

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

Intestinal absorption, metabolism, and excretion of (–)-epicatechin in healthy humans assessed by using an intestinal perfusion technique

(2013) Lucas Actis-Goretta et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metronomic chemotherapy for cancer treatment: a decade of clinical studies

(2013) Adriana Romiti et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

P-glycoprotein ABCB1: a major player in drug handling by mammals

(2013) Piet Borst et al.   JOURNAL OF CLINICAL INVESTIGATION

2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein

(2013) Ishrat Jabeen et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Combined QSAR and molecule docking studies on predicting P-glycoprotein inhibitors

(2013) Wen Tan et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

MDR-selective microbial-based therapy: A novel approach to cancer treatment

(2013) Omar Anwar Elkadi   MEDICAL HYPOTHESES

Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

(2012) Zhen Yang et al.   Anti-Cancer Agents in Medicinal Chemistry

Overview of P-glycoprotein inhibitors: a rational outlook

(2012) Kale Mohana Raghava Srivalli et al.   Brazilian Journal of Pharmaceutical Sciences

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

Structure and Ligand-based Design of P-glycoprotein Inhibitors: A Historical Perspective

(2012) Andreia Palmeira et al.   CURRENT PHARMACEUTICAL DESIGN

PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells

(2012) Can Sarisozen et al.   DRUG DELIVERY

An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1

(2012) Yu Lei et al.   FOOD CHEMISTRY

Effects of Zuccagnia punctata extracts and their flavonoids on the function and expression of ABCB1/P-glycoprotein multidrug transporter

(2012) Elisabetta Chieli et al.   JOURNAL OF ETHNOPHARMACOLOGY

Jatrophane Diterpenes from Euphorbia mellifera and Their Activity as P-Glycoprotein Modulators on Multidrug-Resistant Mouse Lymphoma and Human Colon Adenocarcinoma Cells

(2012) Inês Valente et al.   JOURNAL OF NATURAL PRODUCTS

Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: Possible role of cytochrome p450 3A4 and P-glycoprotein inhibition by baicalein

(2011) Cheng Li et al.   ARCHIVES OF PHARMACAL RESEARCH

Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum

(2011) Theodora G.H.A. Tucker et al.   BIOCHEMICAL PHARMACOLOGY

New Uses for Old Drugs: Pharmacophore-Based Screening for the Discovery of P-Glycoprotein Inhibitors

(2011) Andreia Palmeira et al.   Chemical Biology & Drug Design

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

Quercetin and Rutin Reduced the Bioavailability of Cyclosporine from Neoral, an Immunosuppressant, through Activating P-Glycoprotein and CYP 3A4

(2011) Chung-Ping Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biochemical Mechanism of Modulation of Human P-glycoprotein by Stemofoline

(2011) Wisinee Chanmahasathien et al.   PLANTA MEDICA

Farnesiferol A fromFerula persicaand Galbanic Acid fromFerula szowitsianaInhibit P-Glycoprotein-Mediated Rhodamine Efflux in Breast Cancer Cell Lines

(2011) Mohammad Hanafi-Bojd et al.   PLANTA MEDICA

Overcoming of P-glycoprotein-mediated multidrug resistance in K562/A02 cells using riccardin F and pakyonol, bisbibenzyl derivatives from liverworts

(2011) Mei Ji et al.   BioScience Trends

Structure–activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP)

(2010) Anne Pick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells

(2010) Sang-Yun Lee et al.   ENVIRONMENTAL TOXICOLOGY

Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f rat

(2010) Kyle A. Floyd et al.   EXPERIMENTAL EYE RESEARCH

Tamoxifen reverses the multi-drug-resistance of an established human cholangiocarcinoma cell line in combined chemotherapeutics

(2010) Zhi-Hua Liu et al.   MOLECULAR BIOLOGY REPORTS

Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance

(2010) Wisinee Chanmahasathien et al.   PHYTOMEDICINE

Inhibition of P-Glycoprotein by Wogonin Is Involved with the Potentiation of Etoposide-Induced Apoptosis in Cancer Cells

(2009) Eibai Lee et al.   Annals of the New York Academy of Sciences

PSC833, cyclosporine analogue, downregulates MDR1 expression by activating JNK/c-Jun/AP-1 and suppressing NF-κB

(2009) H. Bark et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

(2009) Claudia Kuntner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Conformational Change Induced by ATP Binding in the Multidrug ATP-Binding Cassette Transporter BmrA†

(2008) Cédric Orelle et al.   BIOCHEMISTRY

Bicalutamide failure in prostate cancer treatment: Involvement of Multi Drug Resistance proteins

(2008) Nicola Antonio Colabufo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla

(2008) Van Thi Bao Nguyen et al.   FITOTERAPIA

Leukemic blast and natural killer cell P-glycoprotein function and inhibition in a clinical trial of zosuquidar infusion in acute myeloid leukemia

(2008) John F. Marcelletti et al.   LEUKEMIA RESEARCH

Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells

(2008) Yonggang Ma et al.   PHYTOMEDICINE