Clinical Efficacy of Carbocysteine in COPD: Beyond the Mucolytic Action

Carbocysteine Modifies Circulating miR-21, IL-8, sRAGE, and fAGEs Levels in Mild Acute Exacerbated COPD Patients: A Pilot Study

(2022) Maria Ferraro et al.   Pharmaceuticals

Goals of COPD treatment: Focus on symptoms and exacerbations

(2020) Claus F. Vogelmeier et al.   RESPIRATORY MEDICINE

Building toolkits for COPD exacerbations: lessons from the past and present

(2019) Elizabeth Sapey et al.   THORAX

Carbocisteine inhibits the expression of Muc5b in COPD mouse model

(2019) Yan Song et al.   Drug Design Development and Therapy

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl−]i in mouse airway cilia

(2018) Yukiko Ikeuchi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effects of Carbocysteine and Beclomethasone on Histone Acetylation/Deacetylation Processes in Cigarette Smoke Exposed Bronchial Epithelial Cells

(2017) Elisabetta Pace et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mucoactive and antioxidant medicines for COPD: consensus of a group of Chinese pulmonary physicians

(2017) Xixin Yan et al.   International Journal of Chronic Obstructive Pulmonary Disease

Effect of carbocisteine on patients with COPD: a systematic review and meta-analysis

(2017) Zheng Zeng et al.   International Journal of Chronic Obstructive Pulmonary Disease

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B

(2017) Luke Bonser et al.   Journal of Clinical Medicine

Carbocisteine attenuates TNF-α-induced inflammation in human alveolar epithelial cells in vitro through suppressing NF-κB and ERK1/2 MAPK signaling pathways

(2016) Wei Wang et al.   ACTA PHARMACOLOGICA SINICA

A review of national guidelines for management of COPD in Europe

(2016) Marc Miravitlles et al.   EUROPEAN RESPIRATORY JOURNAL

Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells

(2016) E. Pace et al.   EXPERIMENTAL GERONTOLOGY

Effect of CArbocisteine in Prevention of exaceRbation of chronic obstructive pulmonary disease (CAPRI study): An observational study

(2016) Antonietta Esposito et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

A mucoactive drug carbocisteine ameliorates steroid resistance in rat COPD model

(2016) Yun Song et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Carbocisteine attenuates hydrogen peroxide-induced inflammatory injury in A549 cells via NF-κB and ERK1/2 MAPK pathways

(2015) Wei Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Carbocysteine restores steroid sensitivity by targeting histone deacetylase 2 in a thiol/GSH-dependent manner

(2015) Yun Song et al.   PHARMACOLOGICAL RESEARCH

Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells

(2013) Elisabetta Pace et al.   CELL STRESS & CHAPERONES

Short- and Long- Term Effects of Cigarette Smoke Exposure on Glutathione Homeostasis in Human Bronchial Epithelial Cells

(2013) Claudia Bazzini et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity

(2013) Amir Hakim et al.   FASEB JOURNAL

Oxidative stress and innate immunity responses in cigarette smoke stimulated nasal epithelial cells

(2013) Elisabetta Pace et al.   TOXICOLOGY IN VITRO

Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells

(2013) Elisabetta Pace et al.   TOXICOLOGY LETTERS

S-Carboxymethyl-L-cysteine

(2012) Steve C. Mitchell et al.   DRUG METABOLISM REVIEWS

Carbocisteine promotes phagocytosis of apoptotic cells by alveolar macrophages

(2011) Masako Inoue et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

S-Carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells

(2011) T. Sumitomo et al.   JOURNAL OF MEDICAL MICROBIOLOGY

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells

(2011) Masanori Asada et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells

(2010) Mutsuo Yamaya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

Carbocisteine Protects Against Emphysema Induced by Cigarette Smoke Extract in Rats

(2010) Masayuki Hanaoka et al.   CHEST

Carbocisteine normalizes the viscous property of mucus through regulation of fucosylated and sialylated sugar chain on airway mucins

(2010) Yuji Ishibashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells

(2009) Motoki YOSHIDA et al.   RESPIROLOGY

S-CMC-Lys Protective Effects on Human Respiratory Cells During Oxidative Stress

(2008) Maria Lisa Garavaglia et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells

(2008) Elisabetta Pace et al.   IMMUNOLOGY

Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

(2008) Jin-Ping Zheng et al.   LANCET

Carbocisteine can scavenge reactive oxygen speciesin vitro

(2008) Hisashi NOGAWA et al.   RESPIROLOGY