Good and Bad Stroma in Pancreatic Cancer: Relevance of Functional States of Cancer-Associated Fibroblasts

Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer

(2022) Ryosuke Ichihara et al.   PATHOLOGY INTERNATIONAL

Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors

(2022) Seiichiro Ishihara et al.   Cancers

Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma

(2022) Yasuyuki Mizutani et al.   BMC CANCER

Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

(2022) Huocong Huang et al.   CANCER CELL

Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets

(2022) Shinelle Menezes et al.   JOURNAL OF PATHOLOGY

Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics

(2022) Tadashi Iida et al.   ONCOGENE

Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

(2022) Kathleen M. McAndrews et al.   Cancer Discovery

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts

(2022) Shun Minatoguchi et al.   Scientific Reports

Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade

(2022) Yuki Miyai et al.   Life Science Alliance

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts

(2021) Yoshihiro Mezawa et al.   FEBS Journal

Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity

(2021) Akitoshi Hara et al.   GENES TO CELLS

Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue

(2021) Takahide Kuwano et al.   PLoS One

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

(2021) Kazuhiro Koikawa et al.   CELL

Fibroblasts positive for meflin have anti-fibrotic property in pulmonary fibrosis

(2021) Yoshio Nakahara et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical and therapeutic relevance of cancer-associated fibroblasts

(2021) Yang Chen et al.   Nature Reviews Clinical Oncology

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin/Islr in Cancer Fibrosis

(2021) Masahide Takahashi et al.   Frontiers in Cell and Developmental Biology

Cancer‐associated fibroblasts that restrain cancer progression (rCAFs): hypotheses and perspectives

(2020) Yuki Miyai et al.   CANCER SCIENCE

Pancreatic cancer stroma: an update on therapeutic targeting strategies

(2020) Abdel N. Hosein et al.   Nature Reviews Gastroenterology & Hepatology

DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS

(2020) Giulia Biffi et al.   PHYSIOLOGICAL REVIEWS

Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer

(2020) Yann Kieffer et al.   Cancer Discovery

Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma

(2020) Yuuki Ohara et al.   ONCOLOGY REPORTS

The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis

(2020) Hiroki Kobayashi et al.   GASTROENTEROLOGY

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

(2019) Boris Hinz et al.   EXPERIMENTAL CELL RESEARCH

Cancer-associated fibroblasts—heroes or villains?

(2019) Krystyna A. Gieniec et al.   BRITISH JOURNAL OF CANCER

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis

(2019) Yasuyuki Mizutani et al.   CANCER RESEARCH

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction

(2019) Akitoshi Hara et al.   CIRCULATION RESEARCH

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

(2019) Lea Monteran et al.   Frontiers in Immunology

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

(2019) Claudia X Dominguez et al.   Cancer Discovery

MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells

(2018) Chao Meng et al.   BIOMEDICINE & PHARMACOTHERAPY

Girdin/GIV Regulates Collective Cancer Cell Migration by Controlling Cell Adhesion and Cytoskeletal Organization

(2018) Xiaoze Wang et al.   CANCER SCIENCE

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

New transcriptional-based insights into the pathogenesis of desmoplastic small round cell tumors (DSRCTs)

(2017) Tiziana Negri et al.   Oncotarget

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Decorin as a multivalent therapeutic agent against cancer

(2016) Thomas Neill et al.   ADVANCED DRUG DELIVERY REVIEWS

TGF  Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis

(2016) D. R. Principe et al.   CANCER RESEARCH

Collective invasion of cancer: Perspectives from pathology and development

(2016) Xiaoze Wang et al.   PATHOLOGY INTERNATIONAL

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

(2016) Antonios Chronopoulos et al.   Nature Communications

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

(2016) Benjamin Le Calvé et al.   Oncotarget

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells

(2016) Keiko Maeda et al.   Scientific Reports

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells

(2016) Muge Sarper et al.   Scientific Reports

Akt-Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression

(2015) Y. Yamamura et al.   CANCER RESEARCH

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

(2015) Nilesh P. Talele et al.   Stem Cell Reports

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

(2014) J. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

CD271+ Subpopulation of Pancreatic Stellate Cells Correlates with Prognosis of Pancreatic Cancer and Is Regulated by Interaction with Cancer Cells

(2012) Kenji Fujiwara et al.   PLoS One

Pancreatic Cancer

(2008) Anirban Maitra et al.   Annual Review of Pathology-Mechanisms of Disease