Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Targeting complement in neurodegeneration: challenges, risks, and strategies

(2022) Wioleta M. Zelek et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice

(2021) Réka Á. Kovács et al.   Frontiers in Immunology

Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys

(2021) Jacob J. E. Koopman et al.   Frontiers in Immunology

Novel Monoclonal Antibodies Against Mouse C1q: Characterisation and Development of a Quantitative ELISA for Mouse C1q

(2021) Robert A. J. Byrne et al.   MOLECULAR NEUROBIOLOGY

Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

(2021) Dong Wang et al.   Frontiers in Cellular Neuroscience

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis

(2021) Raquel Sanchez-Varo et al.   Frontiers in Neuroscience

Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease

(2021) Junhua Xie et al.   Acta Neuropathologica Communications

The blood–brain barrier in health and disease: Important unanswered questions

(2020) Caterina P. Profaci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

(2020) Nicole Scott‐Hewitt et al.   EMBO JOURNAL

Complement Inhibitor Therapy for Myasthenia Gravis

(2020) Khaled Albazli et al.   Frontiers in Immunology

Complement in neurological disorders and emerging complement-targeted therapeutics

(2020) Marinos C. Dalakas et al.   Nature Reviews Neurology

Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice

(2020) Courtney K. Walker et al.   NEUROSCIENCE

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species

(2020) Wioleta M. Zelek et al.   Frontiers in Immunology

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease

(2020) Ryan J. Bevan et al.   Acta Neuropathologica Communications

Development and characterisation of novel anti‐C5 monoclonal antibodies capable of inhibiting complement in multiple species

(2019) Wioleta M. Zelek et al.   IMMUNOLOGY

Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

(2019) Sean J. Pittock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

(2019) Raphael Hesse et al.   Acta Neuropathologica Communications

Extracting the barbs from complement assays: Identification and optimisation of a safe substitute for traditional buffers

(2018) Wioleta M. Zelek et al.   IMMUNOBIOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

(2018) Balázs A. Györffy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Loss of thin spines and small synapses contributes to defective hippocampal function in aged mice

(2018) Benke Xu et al.   NEUROBIOLOGY OF AGING

An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease—A cohort study of 95,442 individuals

(2018) Katrine Laura Rasmussen et al.   Alzheimers & Dementia

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

(2018) Tianjiao Duan et al.   Journal of Neuroinflammation

Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APPNL-G-F/NL-G-F) model of Alzheimer's disease

(2018) Jogender Mehla et al.   NEUROBIOLOGY OF AGING

The Correlation between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer’s Disease

(2017) Angharad R. Morgan et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The membrane attack complex as an inflammatory trigger

(2016) B. Paul Morgan   IMMUNOBIOLOGY

Complement Biomarkers as Predictors of Disease Progression in Alzheimer’s Disease

(2016) Svetlana Hakobyan et al.   JOURNAL OF ALZHEIMERS DISEASE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease

(2016) William T. Hu et al.   Acta Neuropathologica Communications

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of the Membrane Attack Complex of the Complement System Reduces Secondary Neuroaxonal Loss and Promotes Neurologic Recovery after Traumatic Brain Injury in Mice

(2014) K. Fluiter et al.   JOURNAL OF IMMUNOLOGY

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

(2012) Marie E. Benoit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation and Synaptic Loss

(2012) Jagadeesh S. Rao et al.   NEUROCHEMICAL RESEARCH

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

DiOlistic Labeling of Neurons in Tissue Slices: A Qualitative and Quantitative Analysis of Methodological Variations

(2011) Nancy A. Staffend et al.   Frontiers in Neuroanatomy

Synapse elimination during development and disease: immune molecules take centre stage

(2010) Dorothy P. Schafer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s disease

(2008) Jun Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE