ACT001 Inhibits TLR4 Signaling by Targeting Co-Receptor MD2 and Attenuates Neuropathic Pain
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Title
ACT001 Inhibits TLR4 Signaling by Targeting Co-Receptor MD2 and Attenuates Neuropathic Pain
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-06-09
DOI
10.3389/fimmu.2022.873054
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Note: Only part of the references are listed.- Artemisinin inhibits TLR4 signaling by targeting co‐receptor MD2 in microglial BV‐2 cells and prevents lipopolysaccharideinduced blood brain barrier leakage in mice
- (2021) Tianshu Zhang et al. JOURNAL OF NEUROCHEMISTRY
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- (2020) Qiuying Li et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Small-Molecule Modulators of Toll-like Receptors
- (2020) Yibo Wang et al. ACCOUNTS OF CHEMICAL RESEARCH
- Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice
- (2020) Qianqian Liu et al. BEHAVIOURAL BRAIN RESEARCH
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- (2020) Gen Ba et al. CELL CYCLE
- GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
- (2020) Gina L.C. Yosten et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting Inflammation Driven by HMGB1
- (2020) Huan Yang et al. Frontiers in Immunology
- DMAMCL exerts antitumor effects on hepatocellular carcinoma both in vitro and in vivo
- (2020) Shunnan Yao et al. CANCER LETTERS
- Neuropathic pain: From mechanisms to treatment
- (2020) Nanna Brix Finnerup et al. PHYSIOLOGICAL REVIEWS
- The anti-tumor growth effect of a novel agent DMAMCL in rhabdomyosarcoma in vitro and in vivo
- (2019) Ning Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Inappropriate opioid prescription after surgery
- (2019) Mark D Neuman et al. LANCET
- Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury
- (2019) Marieta Georgieva et al. PAIN
- Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain
- (2019) Yinghua Peng et al. BRAIN BEHAVIOR AND IMMUNITY
- ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma
- (2019) Xiaonan Xi et al. Cell Death & Disease
- The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson’s disease in mice
- (2019) Qianqian Liu et al. BEHAVIOURAL BRAIN RESEARCH
- Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia
- (2018) Jing Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
- (2018) Kazuhide Inoue et al. NATURE REVIEWS NEUROSCIENCE
- Targeting toll-like receptor-4 (TLR4)—an emerging therapeutic target for persistent pain states
- (2018) Kelly Bruno et al. PAIN
- Toll-like receptors and their role in persistent pain
- (2018) Michael J. Lacagnina et al. PHARMACOLOGY & THERAPEUTICS
- ACT001 can prevent and reverse tamoxifen resistance in human breast cancer cell lines by inhibiting NF‐κB activation
- (2018) Xiao‐Han Jin et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Pharmacokinetics, tissue distribution and excretion of ACT001 in Sprague-Dawley rats and metabolism of ACT001
- (2018) Xiao-Nan Xi et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain
- (2018) Gang Chen et al. NEURON
- Inflammation in the pathophysiology of neuropathic pain
- (2017) Claudia Sommer et al. PAIN
- Neuropathic pain
- (2017) Luana Colloca et al. Nature Reviews Disease Primers
- Differential Effects of Hydrophobic Core Packing Residues for Thermodynamic and Mechanical Stability of a Hyperthermophilic Protein
- (2016) Katarzyna M. Tych et al. LANGMUIR
- The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation
- (2016) Anja Henn ALTEX-Alternatives to Animal Experimentation
- DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling
- (2015) A L Northcutt et al. MOLECULAR PSYCHIATRY
- Neuropathic pain in the general population: A systematic review of epidemiological studies
- (2013) O. van Hecke et al. PAIN
- Morphine activates neuroinflammation in a manner parallel to endotoxin
- (2012) X. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STD-NMR: application to transient interactions between biomolecules—a quantitative approach
- (2011) Jesus Angulo et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Purinergic systems, neuropathic pain and the role of microglia
- (2011) Kazuhide Inoue et al. EXPERIMENTAL NEUROLOGY
- Saturation-Transfer Difference (STD) NMR: A Simple and Fast Method for Ligand Screening and Characterization of Protein Binding
- (2011) Aldino Viegas et al. JOURNAL OF CHEMICAL EDUCATION
- LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
- (2011) Roman A. Laskowski et al. Journal of Chemical Information and Modeling
- The R.E.D. tools: advances in RESP and ESP charge derivation and force field library building
- (2010) François-Yves Dupradeau et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
- (2009) Oleg Trott et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
- (2009) Beom Seok Park et al. NATURE
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