Heterologous Expression and Evaluation of Novel Plasmodium falciparum Transmission Blocking Vaccine Candidates

A Reproducible and Scalable Process for Manufacturing a Pfs48/45 Based Plasmodium falciparum Transmission-Blocking Vaccine

(2021) Susheel K. Singh et al.   Frontiers in Immunology

Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice

(2021) Sara A. Healy et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasmodium falciparum Pf77 and male development gene 1 as vaccine antigens that induce potent transmission-reducing antibodies

(2021) Abhai K. Tripathi et al.   Science Translational Medicine

Unveiling the Sugary Secrets of Plasmodium Parasites

(2021) Felix Goerdeler et al.   Frontiers in Microbiology

Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes

(2021) Michelle K. Muthui et al.   Frontiers in Cellular and Infection Microbiology

When Is a Plasmodium-Infected Mosquito an Infectious Mosquito?

(2020) Wouter Graumans et al.   TRENDS IN PARASITOLOGY

A Brief History of Protein Sorting Prediction

(2019) Henrik Nielsen et al.   PROTEIN JOURNAL

Engineering a Virus-Like Particle as an Antigenic Platform for a Pfs47-Targeted Malaria Transmission-Blocking Vaccine

(2019) Lampouguin Yenkoidiok-Douti et al.   Scientific Reports

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

(2019) Roos M. Jong et al.   IMMUNOLOGICAL REVIEWS

The Plasmodium falciparum circumsporozoite protein produced in Lactococcus lactis is pure and stable

(2019) Susheel K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum

(2018) Susheel K. Singh et al.   Microbial Cell Factories

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

(2018) Will J. R. Stone et al.   Nature Communications

Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission

(2018) Gaspar E. Canepa et al.   npj Vaccines

Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults

(2018) Issaka Sagara et al.   LANCET INFECTIOUS DISEASES

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

(2018) Frank Lennartz et al.   Nature Communications

Towards clinical development of a Pfs48/45-based transmission blocking malaria vaccine

(2017) Michael Theisen et al.   Expert Review of Vaccines

Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’

(2017) Jing Jin et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

(2017) Susheel K. Singh et al.   Microbial Cell Factories

Functional characterization and comparison of Plasmodium falciparum proteins as targets of transmission-blocking antibodies

(2017) Daria Nikolaeva et al.   MOLECULAR & CELLULAR PROTEOMICS

Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana

(2017) L. E. Amoah et al.   Parasites & Vectors

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

(2017) Fiona Angrisano et al.   Cell Reports

Integrated transcriptomic and proteomic analyses ofP. falciparumgametocytes: molecular insight into sex-specific processes and translational repression

(2016) Edwin Lasonder et al.   NUCLEIC ACIDS RESEARCH

Malaria: Global progress 2000 – 2015 and future challenges

(2016) Richard E. Cibulskis et al.   Infectious Diseases of Poverty

Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults

(2016) Kawsar R. Talaat et al.   PLoS One

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodies

(2015) Susheel K. Singh et al.   VACCINE

A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages

(2014) Michael Theisen et al.   VACCINE

Functional Comparison of Plasmodium falciparum Transmission-Blocking Vaccine Candidates by the Standard Membrane-Feeding Assay

(2013) Kazutoyo Miura et al.   INFECTION AND IMMUNITY

The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays

(2013) Will J. R. Stone et al.   Scientific Reports

Measuring the blockade of malaria transmission – An analysis of the Standard Membrane Feeding Assay

(2012) Thomas S. Churcher et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro

(2009) Andrew M. Blagborough et al.   VACCINE

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

(2008) Y. Liu et al.   GENES & DEVELOPMENT

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH