Immunogenic Cell Death and Role of Nanomaterials Serving as Therapeutic Vaccine for Personalized Cancer Immunotherapy

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

(2022) Peng Liao et al.   CANCER CELL

Hard, Soft, and Hard-and-Soft Drug Delivery Carriers Based on CaCO3 and Alginate Biomaterials: Synthesis, Properties, Pharmaceutical Applications

(2022) Yanqi Huang et al.   Pharmaceutics

Triggering Immune System With Nanomaterials for Cancer Immunotherapy

(2022) Qiyan Li et al.   Frontiers in Bioengineering and Biotechnology

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

(2021) Razan Alzeibak et al.   Journal for ImmunoTherapy of Cancer

Polymeric Nanosystems for Immunogenic Cell Death‐Based Cancer Immunotherapy

(2021) Liwen Fu et al.   MACROMOLECULAR BIOSCIENCE

Novel porphyrazine-based photodynamic anti-cancer therapy induces immunogenic cell death

(2021) Victoria D. Turubanova et al.   Scientific Reports

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

(2021) Emeline Dierge et al.   Cell Metabolism

Lipid-Based Drug Delivery Systems in Regenerative Medicine

(2021) Nina Filipczak et al.   Materials

Deep learning with digital holographic microscopy discriminates apoptosis and necroptosis

(2021) Joost Verduijn et al.   Cell Death Discovery

DCN released from ferroptotic cells ignites AGER-dependent immune responses

(2021) Jiao Liu et al.   Autophagy

Immunogenic ferroptosis and where to find it?

(2021) Robin Demuynck et al.   Journal for ImmunoTherapy of Cancer

Necroptosis‐Inducible Polymeric Nanobubbles for Enhanced Cancer Sonoimmunotherapy

(2020) Wooram Um et al.   ADVANCED MATERIALS

Classification of analytics, sensorics, and bioanalytics with polyelectrolyte multilayer capsules

(2020) Louis Van der Meeren et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In situ Photothermal Activation of Necroptosis Potentiates Black Phosphorus-Mediated Cancer Photo-Immunotherapy

(2020) Henan Zhao et al.   CHEMICAL ENGINEERING JOURNAL

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection

(2020) Tania Løve Aaes et al.   JOURNAL OF IMMUNOLOGY

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

(2020) Cyril Corbet et al.   Nature Communications

Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

(2020) Yang Li et al.   Nature Communications

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies

(2020) Mark P. Chao et al.   Frontiers in Oncology

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

Gasdermins deliver a deadly punch to cancer

(2020) Cheng Shen et al.   CELL RESEARCH

RIPK1‐mediated immunogenic cell death promotes anti‐tumour immunity against soft‐tissue sarcoma

(2020) Henry G Smith et al.   EMBO Molecular Medicine

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Pyroptosis heats tumour immunity

(2020) Kirsty Minton   NATURE REVIEWS DRUG DISCOVERY

Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells

(2020) Chen-Cheng Xue et al.   Science Advances

A 3D Cell Death Assay to Quantitatively Determine Ferroptosis in Spheroids

(2020) Robin Demuynck et al.   Cells

CD47: the next checkpoint target for cancer immunotherapy

(2020) Ridong Feng et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

(2020) Jenny Sprooten et al.   Cells

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Emerging connectivity of programmed cell death pathways and its physiological implications

(2020) Sammy Bedoui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells

(2020) Demet Candas-Green et al.   Nature Communications

Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells

(2020) Ling Li et al.   Nature Biomedical Engineering

Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis

(2020) Ane Ruiz-de-Angulo et al.   iScience

AFM Analysis Enables Differentiation between Apoptosis, Necroptosis, and Ferroptosis in Murine Cancer Cells

(2020) Louis Van der Meeren et al.   iScience

Turning the corner on therapeutic cancer vaccines

(2019) Robert E. Hollingsworth et al.   npj Vaccines

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

(2019) Junhui Yu et al.   Cell Death & Disease

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

The release and activity of HMGB1 in ferroptosis

(2019) Qirong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nanocatalytic Tumor Therapy by Single-Atom Catalysts

(2019) Minfeng Huo et al.   ACS Nano

Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer

(2019) Fan Zhang et al.   ACS Nano

Natural compound inducers of immunogenic cell death

(2019) Marc Diederich   ARCHIVES OF PHARMACAL RESEARCH

The emerging roles of inflammasome‐dependent cytokines in cancer development

(2019) Hanne Van Gorp et al.   EMBO REPORTS

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

(2019) Wenjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

(2019) Mariia S. Saveleva et al.   Frontiers in Chemistry

On the issue of transparency and reproducibility in nanomedicine

(2019) Hon S. Leong et al.   Nature Nanotechnology

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

(2019) Annelise G. Snyder et al.   Science Immunology

Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy

(2019) Xiaoqin Qian et al.   BIOMATERIALS

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

(2019) Inbar Shlomovitz et al.   Cell Communication and Signaling

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

(2019) Tinneke Delvaeye et al.   Scientific Reports

Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine

(2019) Victoria D. Turubanova et al.   Journal for ImmunoTherapy of Cancer

Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality

(2018) Ting Kang et al.   BIOMATERIALS

Oncogene-induced senescence and tumour control in complex biological systems

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy

(2018) André Veillette et al.   TRENDS IN IMMUNOLOGY

An Endogenous Vaccine Based on Fluorophores and Multivalent Immunoadjuvants Regulates Tumor Micro-Environment for Synergistic Photothermal and Immunotherapy

(2018) Ling Li et al.   Theranostics

Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers

(2018) David L Elion et al.   CANCER RESEARCH

Efferocytosis in the tumor microenvironment

(2018) Thomas A. Werfel et al.   Seminars in Immunopathology

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

(2018) Shuaifei Wang et al.   ACS Nano

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death

(2018) Tatiana Mishchenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model

(2018) Inbar Shlomovitz et al.   FEBS Journal

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance

(2017) Norma Bloy et al.   IMMUNOLOGICAL REVIEWS

Necroptotic cell death in anti-cancer therapy

(2017) Olga Krysko et al.   IMMUNOLOGICAL REVIEWS

Nanoparticles for death‑induced gene therapy in cancer (Review)

(2017) Jorge Roacho‑Perez et al.   Molecular Medicine Reports

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome

(2016) Wei-Peng Li et al.   ACS Nano

Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment

(2016) Petra Kucerova et al.   ANTI-CANCER DRUGS

Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation

(2016) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Oxidized PEs trigger death

(2016) Katharina D'Herde et al.   Nature Chemical Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity

(2016) A. L. Silva et al.   Human Vaccines & Immunotherapeutics

Immunogenic peptide discovery in cancer genomes

(2015) Alexandra Snyder et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

How safe are nanomaterials?

(2015) E. Valsami-Jones et al.   SCIENCE

Gene delivery to carcinoma cells via novel non-viral vectors: Nanoparticle tracking analysis and suicide gene therapy

(2014) Senait Gebremedhin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

High hydrostatic pressure induces immunogenic cell death in human tumor cells

(2014) Jitka Fucikova et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor immunity by magnetic nanoparticle-mediated hyperthermia

(2014) Takeshi Kobayashi et al.   Nanomedicine

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

(2013) Marina A. Dobrovolskaia et al.   JOURNAL OF CONTROLLED RELEASE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Many faces of DAMPs in cancer therapy

(2013) O Krysko et al.   Cell Death & Disease

Towards Theranostic Multicompartment Microcapsules: in-situ Diagnostics and Laser-induced Treatment

(2013) Ranhua Xiong et al.   Theranostics

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cancer nanomedicines: So many papers and so few drugs!

(2012) Vincent J. Venditto et al.   ADVANCED DRUG DELIVERY REVIEWS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

One-step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells

(2012) Bert Devriendt et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma

(2012) B. Edris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimuli-responsive LbL capsules and nanoshells for drug delivery

(2011) Mihaela Delcea et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer hyperthermia using magnetic nanoparticles

(2011) Takeshi Kobayashi   Biotechnology Journal

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

(2011) D V Krysko et al.   CELL DEATH AND DIFFERENTIATION

Encapsulation, release and applications of LbL polyelectrolyte multilayer capsules

(2011) Andre G. Skirtach et al.   CHEMICAL COMMUNICATIONS

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases

(2010) Dmitri V. Krysko et al.   APOPTOSIS

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Anisotropic multicompartment micro- and nano-capsules produced via embedding into biocompatible PLL/HA films

(2010) Mihaela Delcea et al.   CHEMICAL COMMUNICATIONS

Multicompartmental Micro- and Nanocapsules: Hierarchy and Applications in Biosciences

(2010) Mihaela Delcea et al.   MACROMOLECULAR BIOSCIENCE

Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy

(2010) N. Kolishetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Tumor Cell Apoptosis or Necrosis by Conditional Expression of Cell Death Proteins: Analysis of Cell Death Pathways and In Vitro Immune Stimulatory Potential

(2009) C. Lohmann et al.   JOURNAL OF IMMUNOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Polymeric carriers: role of geometry in drug delivery

(2008) Eric A Simone et al.   Expert Opinion on Drug Delivery

Apoptosis and necrosis: Detection, discrimination and phagocytosis

(2008) Dmitri V. Krysko et al.   METHODS

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS