Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma

(2021) Prateek Khanna et al.   Science Translational Medicine

The current landscape of nucleic acid therapeutics

(2021) Jayesh A. Kulkarni et al.   Nature Nanotechnology

Organoïdes dérivés des adénocarcinomes pancréatiques

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MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, phase I trial

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Advances in therapeutic peptides targeting G protein-coupled receptors

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Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

(2020) Stefano Garofalo et al.   Nature Communications

Advances in oligonucleotide drug delivery

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Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

(2020) Jiaxuan Chen et al.   Nature Protocols

The current state and future directions of RNAi-based therapeutics

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Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress

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Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi)

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Counter-regulatory renin–angiotensin system in cardiovascular disease

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Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor

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Therapeutic Potential of Small Activating RNAs (saRNAs) in Human cancers

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Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

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Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

(2018) Tuoyi Li et al.   Nature Communications

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

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Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer

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Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

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Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy

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saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription

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Expression of MAS1 in breast cancer

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Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems

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Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex

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Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells

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RNAa Is Conserved in Mammalian Cells

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