The immunomodulatory potential of phage therapy to treat acne: a review on bacterial lysis and immunomodulation

Therapeutic Effect of a Newly Isolated Lytic Bacteriophage against Multi-Drug-Resistant Cutibacterium acnes Infection in Mice

(2021) Ho Yin Pekkle Lam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differentiation and functional plasticity of gamma-delta (γδ) T cells under homeostatic and disease conditions

(2021) Shilpi Giri et al.   MOLECULAR IMMUNOLOGY

Porphyrins produced by acneic Cutibacterium acnes strains activate the inflammasome by inducing K+ leakage

(2021) Karl-Jan Spittaels et al.   iScience

Optimizing Isotretinoin Treatment of Acne: Update on Current Recommendations for Monitoring, Dosing, Safety, Adverse Effects, Compliance, and Outcomes

(2020) Megan N. Landis   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Microbiota in organ transplantation: An immunological and therapeutic conundrum?

(2020) Kenneth J. Dery et al.   CELLULAR IMMUNOLOGY

The Role of NLRP3 Inflammasome in Infection-related, Immune-mediated and Autoimmune Skin Diseases

(2020) Dan Wang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Tailspike with EPS-depolymerase activity, encoded by a phage belonging to a new genus, makes Providencia stuartii susceptible to serum-mediated killing

(2020) Hugo Oliveira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Safety of Combined Fractional Microneedle Radiofrequency and CO2 as an Early Intervention for Inflammatory Acne and Scarring Treated With Concomitant Isotretinoin

(2020) Jihee Kim et al.   DERMATOLOGIC SURGERY

Adverse events related to topical drug treatments for acne vulgaris

(2020) Agnieszka Otlewska et al.   Expert Opinion On Drug Safety

Antibiotic resistance in acne: changes, consequences and concerns

(2020) Ayse Serap Karadag et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Tissue expression of IL‐17A and FOXP3 in acne vulgaris patients

(2020) Azza Gaber Antar Farag et al.   Journal of Cosmetic Dermatology

Impact of Frequent Administration of Bacteriophage on Therapeutic Efficacy in an A. baumannii Mouse Wound Infection Model

(2020) Michael D. Rouse et al.   Frontiers in Microbiology

Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease

(2020) Martin Maronek et al.   Cells

Acne as an altered dermato‐endocrine response problem

(2020) Stefania Briganti et al.   EXPERIMENTAL DERMATOLOGY

A comparison of the effectiveness of azelaic and pyruvic acid peels in the treatment of female adult acne: a randomized controlled trial

(2020) Karolina Chilicka et al.   Scientific Reports

Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis

(2020) Bénédicte Oulès et al.   Nature Communications

Refining the Galleria mellonella Model by Using Stress Marker Genes to Assess Clostridioides difficile Infection and Recuperation during Phage Therapy

(2020) Janet Y. Nale et al.   Microorganisms

Activation of Janus kinase signaling pathway in acne lesions

(2020) Sara Mohamed Awad et al.   Dermatologic Therapy

Bioactive multi-engineered hydrogel offers simultaneous promise against antibiotic resistance and wound damage

(2020) Jikang Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Bacteriophage Interactions with Mammalian Tissue: Therapeutic Applications

(2019) Haein Huh et al.   ADVANCED DRUG DELIVERY REVIEWS

Acne, the Skin Microbiome, and Antibiotic Treatment

(2019) Haoxiang Xu et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Sarecycline: First Global Approval

(2019) Emma D. Deeks   DRUGS

PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults

(2019) Hallie Febvre et al.   Nutrients

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection

(2019) Johanna M. Sweere et al.   SCIENCE

Short-Chain Fatty Acids from Cutibacterium acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

(2019) James A. Sanford et al.   JOURNAL OF IMMUNOLOGY

Ameliorating the antimicrobial resistance crisis: phage therapy

(2019) Dibya Saha et al.   IUBMB LIFE

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis

(2019) Lasha Gogokhia et al.   Cell Host & Microbe

From pathogenesis of acne vulgaris to anti-acne agents

(2019) Tian-Xin Cong et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Alterations in IL-4, IL-10 and IFN-γ levels synergistically decrease lipid content and protein expression of FAS and mature SREBP-1 in human sebocytes

(2019) Jihye Shin et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Atrophic acne scar: A process from altered metabolism of elastic fibers and collagen fibers based on TGF-β1 signaling

(2019) J. Moon et al.   BRITISH JOURNAL OF DERMATOLOGY

An Overview of Acne Therapy, Part 1

(2019) Justin W. Marson et al.   DERMATOLOGIC CLINICS

Staphylococcus epidermidis: A Potential New Player in the Physiopathology of Acne?

(2019) Jean-Paul Claudel et al.   DERMATOLOGY

Phage Therapy of Pneumonia Is Not Associated with an Overstimulation of the Inflammatory Response Compared to Antibiotic Treatment in Mice

(2019) Nicolas Dufour et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The role of the skin microbiota in acne pathophysiology

(2019) S. Ramasamy et al.   BRITISH JOURNAL OF DERMATOLOGY

Cutibacterium acnes phylotypes diversity loss: a trigger for skin inflammatory process

(2019) Marie‐Ange Dagnelie et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies

(2019) Joseph McLaughlin et al.   Microorganisms

Identification of Genes and Pathways Associated with Acne Using Integrated Bioinformatics Methods

(2019) Xianglan Li et al.   DERMATOLOGY

The role of topical probiotics on skin conditions: A systematic review of animal and human studies and implications for future therapies

(2019) Rebecca Knackstedt et al.   EXPERIMENTAL DERMATOLOGY

A Bacteriophage Cocktail Eliminates Salmonella Typhimurium from the Human Colonic Microbiome while Preserving Cytokine Signaling and Preventing Attachment to and Invasion of Human Cells by Salmonella In Vitro

(2019) ZACHARY D. MOYE et al.   JOURNAL OF FOOD PROTECTION

The emerging utility of the cutaneous microbiome in the treatment of acne and atopic dermatitis

(2019) Taylor E. Woo et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems

(2019) Gemma Latter et al.   Pharmaceutics

A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion

(2019) Martin T. Jahn et al.   Cell Host & Microbe

Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling

(2019) Lei Liu et al.   NATURE IMMUNOLOGY

Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness

(2019) Ratanesh K. Seth et al.   Viruses-Basel

Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria

(2019) Gabriel M. F. Almeida et al.   mBio

Caveolin‐1 as a possible target in the treatment for acne

(2019) Ilja L. Kruglikov et al.   EXPERIMENTAL DERMATOLOGY

High bacterial colonization and lipase activity in microcomedones

(2019) Gwendal Josse et al.   EXPERIMENTAL DERMATOLOGY

Immunostimulatory Activities of Coliphages on In Vitro Activated Mammalian Macrophages

(2019) Gizem Yıldızlı et al.   INFLAMMATION

Emerging Therapies for Acne Vulgaris

(2018) Megha K. Trivedi et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells

(2018) M. Mattii et al.   BRITISH JOURNAL OF DERMATOLOGY

Atrophic scar formation in acne patients involves long-acting immune responses with plasma cells and alteration of sebaceous glands

(2018) I. Carlavan et al.   BRITISH JOURNAL OF DERMATOLOGY

Cutibacterium acnes molecular typing: time to standardize the method

(2018) M.-A. Dagnelie et al.   CLINICAL MICROBIOLOGY AND INFECTION

Concomitant Use of 1,550-nm Nonablative Fractional Laser With Low-Dose Isotretinoin for the Treatment of Acne Vulgaris in Asian Patients

(2018) Jun Xia et al.   DERMATOLOGIC SURGERY

A Rationally Designed Multifunctional Antibiotic for the Treatment of Drug-Resistant Acne

(2018) Sumana Ghosh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phenotype and Antimicrobial Activity of Th17 Cells Induced by Propionibacterium acnes Strains Associated with Healthy and Acne Skin

(2018) George W. Agak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The anti-inflammatory activities of Propionibacterium acnes CAMP factor-targeted acne vaccines

(2018) Yanhan Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Practical management of acne for clinicians: An international consensus from the Global Alliance to Improve Outcomes in Acne

(2018) Diane M. Thiboutot et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine®

(2018) S. Pécastaings et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Cutibacterium acnes (Propionibacterium acnes ) and acne vulgaris: a brief look at the latest updates

(2018) B. Dréno et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Immune response patterns in non-communicable inflammatory skin diseases

(2018) K. Eyerich et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Inhibitory effects of superoxide dismutase 3 on Propionibacterium acnes-induced skin inflammation

(2018) Cuong Thach Nguyen et al.   Scientific Reports

Characterization of Two Novel Bacteriophages Infecting Multidrug-Resistant (MDR) Acinetobacter baumannii and Evaluation of Their Therapeutic Efficacy in Vivo

(2018) Kyoungeun Cha et al.   Frontiers in Microbiology

Comparative analyses of biofilm formation among different Cutibacterium acnes isolates

(2018) Torben Kuehnast et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

A Novel Topical Minocycline Foam for the Treatment of Moderate-to-Severe Acne Vulgaris: Results of Two Randomized, Double-Blind, Phase 3 Studies

(2018) Linda Stein Gold et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

TNIP1 Regulates Cutibacterium acnes-Induced Innate Immune Functions in Epidermal Keratinocytes

(2018) Lilla Erdei et al.   Frontiers in Immunology

Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris

(2018) George Zhanel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of Staphylococcus aureus Bacteriophage K on Expression of Cytokines and Activation Markers by Human Dendritic Cells In Vitro

(2018) Helen Freyberger et al.   Viruses-Basel

Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System

(2018) Jonas Van Belleghem et al.   Viruses-Basel

Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms

(2018) Grazyna Majkowska-Skrobek et al.   Frontiers in Microbiology

Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages

(2018) Luis Vitetta et al.   Frontiers in Immunology

Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris

(2018) Alan M. O’Neill et al.   Microbiome

Efficacy of φkm18p phage therapy in a murine model of extensively drug-resistant Acinetobacter baumannii infection

(2018) Jiun-Ling Wang et al.   Infection and Drug Resistance

A bacteriophages journey through the human body

(2017) Jeremy J. Barr   IMMUNOLOGICAL REVIEWS

Update on etiopathogenesis and treatment of Acne

(2017) YasmeenJabeen Bhat et al.   Indian Journal of Dermatology Venereology & Leprology

What is new in the pathophysiology of acne, an overview

(2017) B. Dréno   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Modeling the synergistic elimination of bacteria by phage and the innate immune system

(2017) Chung Yin (Joey) Leung et al.   JOURNAL OF THEORETICAL BIOLOGY

Low-level red LED light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne

(2017) Wen-Hwa Li et al.   LASERS IN SURGERY AND MEDICINE

Dynamic interactions between prophages induce lysis in Propionibacterium acnes

(2017) Teagan L. Brown et al.   RESEARCH IN MICROBIOLOGY

A3R Phage and Staphylococcus aureus Lysate Do Not Induce Neutrophil Degranulation

(2017) Jan Borysowski et al.   Viruses-Basel

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers

(2017) Sophie Nguyen et al.   mBio

Non-antibiotic Isotretinoin Treatment Differentially Controls Propionibacterium acnes on Skin of Acne Patients

(2017) Angela E. Ryan-Kewley et al.   Frontiers in Microbiology

Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes

(2017) Ewa Jończyk-Matysiak et al.   Frontiers in Microbiology

Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages

(2017) Jonas D. Van Belleghem et al.   Scientific Reports

The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence

(2017) Tomasz Olszak et al.   Scientific Reports

Dapsone 7.5% Gel: A Review in Acne Vulgaris

(2016) Zaina T. Al-Salama et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Emergence of fluoroquinolone-resistant Propionibacterium acnes caused by amino acid substitutions of DNA gyrase but not DNA topoisomerase IV

(2016) Keisuke Nakase et al.   ANAEROBE

Inflammasomes and dermatology

(2016) Daniel Coelho de Sá et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

Heterogeneity of Human CD4+T Cells Against Microbes

(2016) Federica Sallusto   Annual Review of Immunology

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet

(2016) N.F. Agamia et al.   BRITISH JOURNAL OF DERMATOLOGY

Oral Isotretinoin

(2016) Jerry Tan et al.   DERMATOLOGIC CLINICS

The use of oral antibiotics in treating acne vulgaris: a new approach

(2016) Georgia Farrah et al.   Dermatologic Therapy

The extinction of topical erythromycin therapy for acne vulgaris and concern for the future of topical clindamycin

(2016) Brett A. Austin et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

A consensus-based practical and daily guide for the treatment of acne patients

(2016) H.P. Gollnick et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Treatment Modalities for Acne

(2016) Lizelle Fox et al.   MOLECULES

Morphologically Distinct Escherichia coli Bacteriophages Differ in Their Efficacy and Ability to Stimulate Cytokine Release In Vitro

(2016) Mohammadali Khan Mirzaei et al.   Frontiers in Microbiology

Antibody Production in Response to Staphylococcal MS-1 Phage Cocktail in Patients Undergoing Phage Therapy

(2016) Maciej Żaczek et al.   Frontiers in Microbiology

T4 Phage Tail Adhesin Gp12 Counteracts LPS-Induced Inflammation In Vivo

(2016) Paulina Miernikiewicz et al.   Frontiers in Microbiology

TLR-2 Recognizes Propionibacterium acnes CAMP Factor 1 from Highly Inflammatory Strains

(2016) Coralie Lheure et al.   PLoS One

The balance of metagenomic elements shapes the skin microbiome in acne and health

(2016) Emma Barnard et al.   Scientific Reports

Adverse Effects of Acne Medications: Recognition and Management

(2015) Mollie D. Oudenhoven et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Structural Biology of Innate Immunity

(2015) Qian Yin et al.   Annual Review of Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine Lung

(2015) Rishi Pabary et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Management of severe acne

(2015) C.C. Zouboulis et al.   BRITISH JOURNAL OF DERMATOLOGY

Propionibacterium acnes in the Pathogenesis and Immunotherapy of Acne Vulgaris

(2015) Pei-Feng Liu et al.   CURRENT DRUG METABOLISM

Propionibacterium acnes Promotes Th17 and Th17/Th1 Responses in Acne Patients

(2015) Magdalena Kistowska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

From new findings in acne pathogenesis to new approaches in treatment

(2015) H. P. M. Gollnick   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Interleukin-2: Biology, Design and Application

(2015) Natalia Arenas-Ramirez et al.   TRENDS IN IMMUNOLOGY

Oral Application of T4 Phage Induces Weak Antibody Production in the Gut and in the Blood

(2015) Joanna Majewska et al.   Viruses-Basel

Mammalian Host-Versus-Phage immune response determines phage fate in vivo

(2015) Katarzyna Hodyra-Stefaniak et al.   Scientific Reports

Acne vulgaris

(2015) Sara Moradi Tuchayi et al.   Nature Reviews Disease Primers

Strain Specific Phage Treatment for Staphylococcus aureus Infection Is Influenced by Host Immunity and Site of Infection

(2015) Nathan B. Pincus et al.   PLoS One

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Emerging drugs for the treatment of acne

(2014) Imran Aslam et al.   EXPERT OPINION ON EMERGING DRUGS

Observation of inflammatory responses in mice orally fed with bacteriophage T7

(2014) K. Park et al.   JOURNAL OF APPLIED MICROBIOLOGY

Immunogenicity Studies of Proteins Forming the T4 Phage Head Surface

(2014) K. D browska et al.   JOURNAL OF VIROLOGY

IL-17/Th17 Pathway Is Activated in Acne Lesions

(2014) Hanna-Leena Kelhälä et al.   PLoS One

Propionibacterium acnes Induces IL-1β Secretion via the NLRP3 Inflammasome in Human Monocytes

(2013) Min Qin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D

(2013) George W. Agak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Propionibacterium acnes: an update on its role in the pathogenesis of acne

(2013) C. Beylot et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Bacterial skin commensals and their role as host guardians

(2013) G.J.M. Christensen et al.   Beneficial Microbes

Bacteriophages InfectingPropionibacterium acnes

(2013) Holger Brüggemann et al.   Biomed Research International

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

New developments in our understanding of acne pathogenesis and treatment

(2009) Ichiro Kurokawa et al.   EXPERIMENTAL DERMATOLOGY

Emerging drugs for acne

(2009) Kirk A James et al.   EXPERT OPINION ON EMERGING DRUGS

Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin

(2009) Philippe A. Grange et al.   PLoS Pathogens