Pathological Mechanism and Targeted Drugs of COPD

Alkylating and oxidative stresses in smoking and non-smoking patients with COPD: Implications for lung carcinogenesis

(2021) Ying-Ming Shih et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway

(2021) Meng-Yu Zhang et al.   LIFE SCIENCES

NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea

(2021) Xu Wu et al.   Frontiers in Immunology

Macrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures

(2021) Hiroto Takiguchi et al.   Scientific Reports

The PI3K∂-Selective Inhibitor Idelalisib Induces T- and NK-Cell Dysfunction Independently of B-Cell Malignancy-Associated Immunosuppression

(2021) Lisa Rohrbacher et al.   Frontiers in Immunology

Inflammatory Biomarkers Interleukin 1 Beta (IL-1β) and Tumour Necrosis Factor Alpha (TNF-α) Are Differentially Elevated in Tobacco Smoke Associated COPD and Biomass Smoke Associated COPD

(2021) Bellipady Shyam Prasad Shetty et al.   Toxics

An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial

(2021) Anthony Cahn et al.   International Journal of Chronic Obstructive Pulmonary Disease

Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials

(2021) Malcolm Begg et al.   International Journal of Chronic Obstructive Pulmonary Disease

Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study

(2021) William Fahy et al.   International Journal of Chronic Obstructive Pulmonary Disease

Inhaled Dual Phosphodiesterase 3/4 Inhibitors for the Treatment of Patients with COPD: A Short Review

(2021) Clémence Martin et al.   International Journal of Chronic Obstructive Pulmonary Disease

Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease

(2021) Amel Nasri et al.   Cells

Sulforaphane Activates a Lysosome-dependent Transcriptional Program to Mitigate Oxidative Stress

(2020) Dan Li et al.   Autophagy

The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: Asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis

(2020) Hiroyuki Nagase et al.   ALLERGOLOGY INTERNATIONAL

Role of p38-mitogen-activated protein kinase in COPD: pathobiological implications and therapeutic perspectives

(2020) Corrado Pelaia et al.   Expert Review of Respiratory Medicine

Targeting the MAPK Pathway in KRAS-Driven Tumors

(2020) Matthias Drosten et al.   CANCER CELL

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

(2020) Wei Rao et al.   CELL

Regulation of DNA methylation signatures on NF-κB and STAT3 pathway genes and TET activity in cigarette smoke extract–challenged cells/COPD exacerbation model in vitro

(2020) Gagandeep Kaur et al.   CELL BIOLOGY AND TOXICOLOGY

Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway

(2020) Tao Li et al.   MOLECULAR IMMUNOLOGY

Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells

(2020) Xinli An et al.   Anti-Cancer Agents in Medicinal Chemistry

Inflammatory Endotype Associated Airway Microbiome in COPD Clinical Stability and Exacerbations – A Multi-Cohort Longitudinal Analysis

(2020) Zhang Wang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD

(2020) John T. Benjamin et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD

(2020) Durga Mahor et al.   BMC Pulmonary Medicine

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Experimental and investigational phosphodiesterase inhibitors in development for asthma

(2019) Polyxeni Ntontsi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease

(2019) Xuejiao Sun et al.   CURRENT DRUG METABOLISM

Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production

(2019) Md. Samsuzzaman et al.   LIFE SCIENCES

Benralizumab for the Prevention of COPD Exacerbations

(2019) Gerard J. Criner et al.   NEW ENGLAND JOURNAL OF MEDICINE

The etiologic origins for chronic obstructive pulmonary disease

(2019) Xinwei Huang et al.   International Journal of Chronic Obstructive Pulmonary Disease

Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation

(2019) Yin-Fang Wu et al.   Autophagy

Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways

(2019) Huahong Yang et al.   Cell Communication and Signaling

Comparison of oxidant/antioxidant balance in COPD and non-COPD smokers

(2019) Yusuf Aydemir et al.   HEART & LUNG

NLRP3 inflammasome activity is upregulated in an in-vitro model of COPD exacerbation

(2019) Noy Nachmias et al.   PLoS One

Eosinophil Inflammation and Hyperresponsiveness in the Airways as Phenotypes of COPD, and Usefulness of Inhaled Glucocorticosteroids

(2019) Hiroaki Kume et al.   Frontiers in Pharmacology

LncRNA MIR155HG regulates M1/M2 macrophage polarization in chronic obstructive pulmonary disease

(2019) Nannan Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Predicting response to benralizumab in chronic obstructive pulmonary disease: analyses of GALATHEA and TERRANOVA studies

(2019) Gerard J Criner et al.   Lancet Respiratory Medicine

WNT/RYK signaling restricts goblet cell differentiation during lung development and repair

(2019) Hyun-Taek Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic value of platelet and neutrophil to lymphocyte ratio in COPD patients

(2019) Ahmed Gouda El-Gazzar et al.   Expert Review of Respiratory Medicine

LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD

(2019) Jürgen Knobloch et al.   Journal of Clinical Medicine

M1 Macrophage Activated by Notch Signal Pathway Contributed to Ventilator-Induced Lung Injury in Chronic Obstructive Pulmonary Disease Model

(2019) Hongping Huang et al.   JOURNAL OF SURGICAL RESEARCH

Macrophages: Their role, activation and polarization in pulmonary diseases

(2018) Shweta Arora et al.   IMMUNOBIOLOGY

Valsartan attenuates bleomycin-induced pulmonary fibrosis by inhibition of NF-κB expression and regulation of Th1/Th2 cytokines

(2018) Hoda Mojiri-Forushani et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Nrf2 attenuates inflammatory response in COPD/emphysema: Crosstalk with Wnt3a/β-catenin and AMPK pathways

(2018) Wenhui Cui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Blood MCP-1 levels are increased in chronic obstructive pulmonary disease patients with prevalent emphysema

(2018) Antonino Di Stefano et al.   International Journal of Chronic Obstructive Pulmonary Disease

Inhaled corticosteroids in COPD: Friend or foe?

(2018) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

The short term bronchodilator effects of the dual PDE3 and PDE4 inhibitor RPL554 in COPD

(2018) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells

(2017) Tiina Keränen et al.   INFLAMMATION RESEARCH

Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology

(2017) Eva Sahakian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease

(2017) Ian D. Pavord et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD

(2017) A. Cahn et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice

(2017) J. Lu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Nucleotide-Binding Oligomerization Domain–Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Regulates Bronchial Epithelial Cell Injury and Proapoptosis after Exposure to Biomass Fuel Smoke

(2016) Chen Li et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Pathology of Chronic Obstructive Pulmonary Disease: Progress in the 20th and 21st Centuries

(2016) Kyra Berg et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells

(2016) Su Ui Lee et al.   CYTOKINE

Roflumilast: a review of its use in the treatment of COPD

(2016) Jadwiga Wedzicha et al.   International Journal of Chronic Obstructive Pulmonary Disease

High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial

(2016) Dennis Niewoehner et al.   International Journal of Chronic Obstructive Pulmonary Disease

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

(2016) Robert A. Wise et al.   PLoS One

Feasibility of Computed Tomography in a Multicenter COPD Trial: A Study of the Effect of AZD9668 on Structural Airway Changes

(2015) Lars H. Nordenmark et al.   ADVANCES IN THERAPY

CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease

(2015) Stephen I. Rennard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

(2015) Zdenka Navratilova et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial

(2015) Fernando J Martinez et al.   LANCET

Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

(2015) C F de la Cruz-Herrera et al.   ONCOGENE

Novel aspects of pathogenesis and regeneration mechanisms in COPD

(2015) Ruta Aldonyte et al.   International Journal of Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury

(2014) Mariona Pinart et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alpha-1 Antitrypsin Deficiency in Iranian Patients with Chronic Obstructive Pulmonary Disease

(2014) Bita Geramizadeh et al.   Iranian Red Crescent Medical Journal

High-Dose N-Acetylcysteine in Stable COPD

(2013) Hoi Nam Tse et al.   CHEST

Understanding the paradigm shift to computational social science in the presence of big data

(2013) Ray M. Chang et al.   DECISION SUPPORT SYSTEMS

Muc5b is required for airway defence

(2013) Michelle G. Roy et al.   NATURE

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

(2013) William MacNee et al.   THORAX

Role of CXCL5 in Leukocyte Recruitment to the Lungs during Secondhand Smoke Exposure

(2012) Gayathriy Balamayooran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD

(2012) Audreesh Banerjee et al.   CURRENT OPINION IN PHARMACOLOGY

Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: A randomised controlled trial

(2012) Ronald Dahl et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Long-term safety study of infliximab in moderate-to-severe chronic obstructive pulmonary disease

(2012) Stephen I. Rennard et al.   RESPIRATORY MEDICINE

TNFα antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial

(2012) Shawn D Aaron et al.   THORAX

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

(2011) Nicolas Mercado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

(2011) Deepti Malhotra et al.   JOURNAL OF CLINICAL INVESTIGATION

Sulforaphane inhibitsde novosynthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract

(2011) Warren Starrett et al.   Journal of Immunotoxicology

AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD

(2011) Piotr Kuna et al.   RESPIRATORY MEDICINE

Current Perspectives on Role of Chromatin Modifications and Deacetylases in Lung Inflammation in COPD

(2009) Saravanan Rajendrasozhan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Potential Adverse Effects of Bronchodilators in the Treatment of Airways Obstruction in Older People

(2009) Preeti Gupta et al.   DRUGS & AGING

A Randomized, Placebo-Controlled Study of the Effects of the p38 MAPK Inhibitor SB-681323 on Blood Biomarkers of Inflammation in COPD Patients

(2009) Dave Singh et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Chronic obstructive pulmonary disease in non-smokers

(2009) Sundeep S Salvi et al.   LANCET