Article
Immunology
Chiranjib Chakraborty, Manojit Bhattacharya, Ashish Ranjan Sharma, Kuldeep Dhama
Summary: Research has shown that smallpox vaccines can be used to prevent monkeypox, and this article discusses the importance of vaccines and vaccinations against monkeypox, while exploring potential models for the eradication of MPX in middle to low-economic countries.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Naseem Mohammed Abdulla, Faris El-Dahiyat, Moyad Shahwan, Nageeb Hassan, Obaida Jairoun Dr, Nuha Ghazi Alyousef, Safia Sharif, Ammar Ali Saleh Jaber
Summary: The study aimed to assess the knowledge of Al Ain University students in the UAE regarding the source, signs/symptoms, transmission, prevention, and treatment of human monkeypox. The results showed that the students' knowledge of monkeypox was relatively low, particularly in terms of epidemiology, symptoms, and treatments.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Eva Orviz, Anabel Negredo, Oskar Ayerdi, Ana Vazquez, Ana Munoz-Gomez, Sara Monzon, Petunia Clavo, Angel Zaballos, Mar Vera, Patricia Sanchez, Noemi Cabello, Pilar Jimenez, Jorge A. Perez-Garcia, Sarai Varona, Jorge del Romero, Isabel Cuesta, Alberto Delgado-Iribarren, Montse Torres, Inigo Sagastagoitia, Gustavo Palacios, Vicente Estrada, Maria Paz Sanchez-Seco
Summary: This observational study focused on monkeypox cases in Madrid, Spain, and investigated the clinical and virological aspects of the disease. The findings revealed that the virus circulating in Spain belongs to the western African clade, mainly affecting cisgender men who have sex with men (MSM). The first symptom of the disease was skin lesions, and the disease followed a self-limited course.
JOURNAL OF INFECTION
(2022)
Review
Oncology
Miaojin Zhu, Jia Ji, Danrong Shi, Xiangyun Lu, Baohong Wang, Nanping Wu, Jie Wu, Hangping Yao, Lanjuan Li
Summary: Monkeypox, caused by the monkeypox virus, has become a global concern during the ongoing COVID-19 pandemic. The re-emergence of this virus and outbreaks in multiple nonendemic countries require attention and control measures.
FRONTIERS OF MEDICINE
(2022)
Review
Chemistry, Analytical
Tais Aparecida Reis Cordeiro, Mayra Asevedo Campos de Resende, Simone Cristina dos Santos Moraes, Diego Leoni Franco, Arnaldo Cesar Pereira, Lucas Franco Ferreira
Summary: Neglected tropical diseases are a group of infectious and parasitic diseases prevalent in tropical and subtropical regions, with limited access to proper healthcare. The development of low-cost biosensors for fast diagnosis in these areas is crucial for better treatment and eradication. While progress has been made in the past decade, challenges remain in early detection of neglected tropical diseases using biosensors.
Article
Multidisciplinary Sciences
Tadesse Teferi Mersha, Biruk Mekonnen Wolde, Nigus Abebe Shumuye, Abrha Bsrat Hailu, Abrahim Hassen Mohammed, Yisehak Tsegaye Redda, Birhanu Hadush Abera, Habtamu Taddele Menghistu
Summary: This study utilized a one health approach to prioritize and rank neglected tropical zoonotic diseases in Tigray National Regional State, Ethiopia. Rabies was identified as the most prioritized disease in the region, highlighting the importance of addressing zoonotic diseases through collaborative efforts between human and animal health sectors.
Review
Rheumatology
Rasmi Ranjan Sahoo, Anupam Wakhlu, Vikas Agarwal
Summary: Dealing with rheumatic diseases in tropical countries is complex due to limited healthcare infrastructure, lack of diagnostic and therapeutic facilities, impact of dominant prevalent diseases, and challenges in differentiating from infectious and non-infectious disease mimics. Several tropical diseases present with musculoskeletal and rheumatic manifestations, leading to delayed diagnosis or misdiagnosis and poor patient outcomes.
CLINICAL RHEUMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Deborah Oluwaseun Shomuyiwa, Emery Manirambona
Summary: The Monkeypox virus, declared a global emergency outbreak, has received increased response worldwide. However, the African healthcare community has not responded urgently to the growing outbreak. The impact of COVID-19 across sectors necessitates proactive response patterns. The emphasis on strengthening health systems, highlighted by the COVID-19 pandemic, emphasizes the need for knowledge management, multisectoral and international collaboration, and capacity building. The complexities of transmission require interventions that promote equity, justice, and financial protection for the population.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Pharmacology & Pharmacy
Rachel H. Clare, Steven R. Hall, Rohit N. Patel, Nicholas R. Casewell
Summary: Snakebite envenoming causes up to 138,000 deaths annually, making it the deadliest neglected tropical disease. Current treatment with biologic antivenoms is outdated and expensive, but there is great potential in developing small molecule drugs to inhibit venom toxins. Strategies successful in treating other NTDs could be utilized to facilitate the development of next-generation snakebite treatments.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
Martin Walker, Jonathan I. D. Hamley, Philip Milton, Frederic Monnot, Sally Kinrade, Sabine Specht, Belen Pedrique, Maria-Gloria Basanez
Summary: Drug-based interventions are crucial in addressing major diseases, with a growing consensus on the need for new therapeutic options in some cases. In this field, minimizing wastage of money and resources is essential.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Ian B. Augsburger, Grace K. Galanthay, Jacob H. Tarosky, Jan Rychtar, Dewey Taylor
Summary: Monkeypox, a viral disease, has spread to nearly 60 countries worldwide. Without vaccination, monkeypox can become endemic in previously unaffected regions, including the United States. Not vaccinating often seems to be the optimal solution from an individual's perspective. Moreover, without centrally mandated minimal vaccination rates, the population could easily revert to not vaccinating.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Hollie-Ann Hatherell, Hope Simpson, Rebecca F. Baggaley, T. Deirdre Hollingsworth, Rachel L. Pullan
Summary: The WHO's 2030 road map for neglected tropical diseases highlights the importance of strengthened, institutionalized post-elimination surveillance, but lacks practical guidance on implementation. Nationally representative survey programs, such as DHS, may provide a platform for integrating disease surveillance within national health systems, with a focus on maximizing utility and addressing priorities for further data collection and characterization.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Wendemagegn Enbiale, Alemayehu Bekele, Nigus Manaye, Fikre Seife, Zeyede Kebede, Filmon Gebremeskel, Johan van Griensven
Summary: Subcutaneous mycoses are endemic in Ethiopia, with cases reported throughout the country, especially in the northern regions. The lack of research and surveillance programs for these diseases highlights the need for routine programs and systems to identify and record cases.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Pharmacology & Pharmacy
Leonardo L. G. Ferreira, Josue de Moraes, Adriano D. Andricopulo
Summary: Neglected tropical diseases, such as leishmaniasis and schistosomiasis, continue to be a public health challenge in developing countries. However, advancements in drug discovery using modern strategies have shown promise in addressing these diseases by combining medicinal chemistry and parasite biology.
DRUG DISCOVERY TODAY
(2022)
Article
Immunology
Amanda Minter, Lorenzo Pellis, Graham F. Medley, T. Deirdre Hollingsworth
Summary: As countries strive to meet WHO goals for reducing morbidity and eliminating disease transmission, they will need to plan for the next stages of surveillance and control in low prevalence settings. Going beyond simple predictions of treatment program effectiveness, more nuanced intervention choices informed by quantitative analyses will be necessary for sustainable gains in the long term. Identifying policy goals and finding the right balance between intervention and surveillance constraints will be key challenges in achieving multiple aims such as minimizing morbidity and costs simultaneously.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Parasitology
Ashwaq M. Al Nazawi, Jabir Aqili, Mohammed Alzahrani, Philip J. McCall, David Weetman
PARASITES & VECTORS
(2017)
Article
Biology
Yasser A. Attia, Ashwaq M. Al Nazawi, Hassan Elsayed, Mahmoud W. Sadik
Summary: This study introduced a novel nanoparticle-based method to stimulate the production of hyaluronic acid by Streptococcus equi subsp. Zooepidemicus. Results indicated that the incubation of bacteria with CNTs under UV-irradiation significantly increased HA production, with the nanoparticles serving as coenzymes to induce mutation and enhance production.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Virology
Fatmah M. A. Naemi, Shurooq Al-adwani, Heba Al-khatabi, Ashwaq Al-nazawi
Summary: Regional variations in incidence and severity of COVID-19 are influenced by human leukocyte antigen (HLA) polymorphism. This study focused on the association between HLA genotype and COVID-19 severity in South Asian patients. The study identified differences in HLA allele frequencies between mild, severe, and fatal COVID-19 cases, with some significant associations observed, although significance decreased after statistical corrections. Ethnicity plays a role in the interaction between HLA system and COVID-19 outcomes, emphasizing the need for broader genetic variation studies for infection prognosis and vaccine effectiveness assessment.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Entomology
Ashwaq M. Al Nazawi, Simon Ashall, David Weetman
Summary: In Saudi Arabia, the Ae. aegypti populations in Jeddah and Makkah show full susceptibility to both temephos and Bti, suggesting they can be used as part of vector control programs for dengue prevention in the region. This data indicates the potential importance of rotational or spatial management strategies to address insecticide resistance.
ENTOMOLOGICAL RESEARCH
(2021)
Article
Virology
Fatmah M. A. Naemi, Shurooq Al-adwani, Heba Al-khatabi, Ashwaq Al-nazawi
Summary: HLA polymorphism is associated with variations in susceptibility to COVID-19 infection among Saudi patients. Differences in HLA allele frequencies were found between infected and deceased patients, suggesting a potential role in determining infection outcomes. Further research with larger sample sizes from diverse populations is needed to establish a strong association for clinical application.
Article
Infectious Diseases
Fatmah M. A. Naemi, Shurooq Al-adwani, Ashwaq Al-nazawi, Heba Al-khatabi
Summary: The study found that high serum ferritin levels in COVID-19 patients are associated with increased infection severity and mortality, which may be influenced by HLA polymorphism.
INFECTIOUS DISEASES
(2021)
Article
Parasitology
Abadi M. Mashlawi, Ashwaq M. Al-Nazawi, Elsiddig M. Noureldin, Hussain Alqahtani, Jazem A. Mahyoub, Jassada Saingamsook, Mustapha Debboun, Martha Kaddumukasa, Hesham M. Al-Mekhlafi, Catherine Walton
Summary: Research conducted in southwestern Saudi Arabia found that Aedes aegypti populations carry three known kdr mutations, as well as wild type genotypes. Investigation in Saudi Arabia and other countries showed higher genetic diversity in Saudi Arabia, particularly in Jazan and Sahil regions, compared to Jeddah, Makkah, and Madinah regions.
PARASITES & VECTORS
(2022)
Article
Chemistry, Multidisciplinary
Marwa A. Ibrahim, Eman M. Helmy, Ashwaq M. Al Nazawi, Mahmoud W. Sadek, Mohamed S. Abdelatif
Summary: The research focused on isolating fungal isolates capable of degrading NPEOs from secondary activated sludge. Screening experiments identified eight promising fungal isolates, with one new species Penicillium chrysogenum achieving a high degradation rate of 80%. Toxicity tests revealed cytotoxic activity of Penicillium chrysogenum against mammalian and human lung fibroblast cells.
EGYPTIAN JOURNAL OF CHEMISTRY
(2021)
Meeting Abstract
Public, Environmental & Occupational Health
Ashwaq M. Alnazawi, Philip J. McCall, David Weetman
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)
