Review
Oncology
Zhuoya Yu, Xiangxiang Zhou, Xin Wang
Summary: Metabolic reprogramming, a hallmark of cancer progression, supports tumorigenesis and tumor progression by allowing cells to uptake essential nutrients and altering metabolic pathways to meet increased demands for energy and biosynthetic precursors. Activated oncogenes coordinate with altered metabolism to control cell-autonomous pathways, potentially leading to tumorigenesis. Targeting metabolic features of hematologic malignancies has shown promising therapeutic potential in both clinical and preclinical studies.
Review
Pharmacology & Pharmacy
Jiaxin Li, Xiaoxuan Zhai, Xiao Sun, Shengchuan Cao, Qiuhuan Yuan, Jiali Wang
Summary: This review summarizes recent findings on metabolic reprogramming occurring in different cell types during pulmonary fibrosis, especially those related to glucose, lipid, and amino acid metabolism, with the aim of identifying novel treatment targets for pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Environmental Sciences
Yihui Ruan, Xin Fang, Tingyue Guo, Yiting Liu, Yu Hu, Xuening Wang, Yuxin Hu, Lanyue Gao, Yongfang Li, Jingbo Pi, Yuanyuan Xu
Summary: Chronic exposure to arsenic is associated with various cancers, with metabolic reprogramming being a key mechanism. Research has primarily focused on glucose reprogramming induced by arsenic exposure. Apart from enhanced glycolysis, arsenic may also disrupt lipid deposition and induce one-carbon metabolism pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Oncology
Jinbowen Yan, Fangzhi Xu, Dan Zhou, Shuo Zhang, Bo Zhang, Qingwei Meng, Qiubo Lv
Summary: Metabolic reprogramming is the alteration of metabolic pathways in cancer cells to support their growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle, leading to the production of metabolic intermediates for cellular component biosynthesis and energy homeostasis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wen Ya Su, Lu Yao Tian, Lan Pin Guo, Lu Qi Huang, Wen Yuan Gao
Summary: Tumor metabolic reprogramming is closely associated with oncogenic signaling. Not only mutations or deletion of oncogenes, but also the reprogramming of cellular metabolism play a crucial role in tumorigenesis. The PI3K/AKT signaling pathway mediates the metabolic switch in cancer cells and immune cells in the tumor microenvironment. PI3K/AKT regulates multiple steps of metabolism, including glucose, lipids, and amino acids, and targeting this pathway could effectively impede the oncogenic process and serve as biomarkers for tumor diagnosis and treatment. This review summarizes the significant impact of PI3K/AKT signaling on tumor metabolism, providing better understanding for therapeutic strategies targeting cancer cell metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Biochemistry & Molecular Biology
Tao Shen, Tingting Wang
Summary: Plenty of research has shown significant changes in metabolism due to COVID-19, leading to the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid, glucose, cholesterol and fatty acid is a distinctive characteristic of COVID-19 infection, offering new insights into COVID-19 pathophysiology. This metabolic reprogramming provides opportunities for developing novel biomarkers and therapeutic agents for effective adjuvant therapies against COVID-19 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Maryam Khoshnejat, Ali Mohammad Banaei-Moghaddam, Ali Akbar Moosavi-Movahedi, Kaveh Kavousi
Summary: Type 2 diabetes mellitus (T2DM) is a challenging and progressive metabolic disease caused by insulin resistance. Skeletal muscle dysfunction is implicated in the disturbance of glucose homeostasis and the development of insulin resistance. Understanding metabolism reprogramming in newly diagnosed patients provides opportunities for early diagnosis and treatment.
Review
Chemistry, Medicinal
Macus Tien Kuo, Helen H. W. Chen, Lynn G. Feun, Niramol Savaraj
Summary: Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that are essential for the growth of highly proliferative cells such as cancers. Targeting these amino acids through amino acid starvation strategies has shown promise in clinical applications, but drug resistance remains a major obstacle, primarily due to reactivation of key enzymes and reprogramming of compensatory survival pathways.
Article
Oncology
Jiecheng Yang, Fangzhou Liu, Ying Wang, Lei Qu, Aifu Lin
Summary: Long non-coding RNAs (lncRNAs) play important roles in cellular programs, modulating gene transcription and kinase cascades to impact tumor initiation and progression. This review summarizes the role of lncRNAs in tumor metabolic reprogramming and immune environment remodeling, and discusses the advancements in clinical applications.
Article
Cell Biology
Xiaoyu Zhang, Yan Liu, Froylan Sosa, Sumedha Gunewardena, Peter A. Crawford, Amanda C. Zielen, Kyle E. Orwig, Ning Wang
Summary: Nutrient transporter genes are downregulated in germ cells during meiotic initiation, and this process requires the presence of Stra8. Stra8 binds to these genes and induces their H3K27 deacetylation. In the absence of Stra8, germ cells continue to uptake glutamine and glucose, leading to hyperactive mTORC1/PKA activities.
Review
Oncology
Zihao Wang, Xingyun Wu, Hai-Ning Chen, Kui Wang
Summary: Metastasis is the major cause of cancer death as cancer cells can colonize in distant organs. Metastases reprogram their metabolic states to adapt to new environments, displaying different metabolic properties compared with primary lesions. Amino acid metabolic reprogramming plays a crucial role in cancer metastasis, providing energy supply and maintaining homeostasis. This review summarizes the role of amino acid metabolism in cancer cell colonization in common metastatic organs and discusses the potential of targeting organ-specific metastasis for cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shubhangi Saxena, Neha Dagar, Vishwadeep Shelke, Maciej Lech, Pragyanshu Khare, Anil Bhanudas Gaikwad
Summary: The kidney undergoes metabolic reprogramming in various disease states, and understanding the involved bioenergetic pathways and developing targeted interventions are crucial for addressing the high number of kidney disease cases worldwide. Reprogramming of metabolic pathways has been observed in kidney disease, and therapies targeting these pathways have shown promising results in retarding disease progression. This review focuses on potential pharmacological interventions targeting metabolic reprogramming that have advanced through clinical trials and preclinical studies, with the aim of managing kidney disease effectively in the future.
DRUG DISCOVERY TODAY
(2023)
Review
Immunology
Rebecca R. Crowther, Joseph E. Qualls
Summary: This article provides a summary of the current knowledge on anti-Mtb immunity, focusing on immune cell amino acid metabolism, specifically discussing the roles of L-arginine and L-tryptophan in TB patients. By uncovering the immune cell contribution during Mtb infection and how amino acid utilization regulates their functions, novel host-directed therapies may be developed and refined to help eradicate TB.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Qifan Hu, Yutong Li, Dan Li, Yi Yuan, Keru Wang, Lu Yao, Zhujun Cheng, Tianyu Han
Summary: Metabolic reprogramming, a key characteristic of cancer cells, is crucial for their proliferation and survival. Long non-coding RNAs (lncRNAs) have been found to play an important role in regulating amino acid metabolism in cancer cells. Understanding the role of lncRNAs in cancer metabolic reprogramming, especially in amino acid metabolism, could provide new insights for anti-cancer drug development.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Oncology
Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Zhen Cai
Summary: Macrophages are key regulators of tissue homeostasis, involved in tissue development, repair, and defense against pathogens. TAMs play a crucial role in the tumor microenvironment, impacting tumor initiation, growth, invasion, and metastasis. The metabolic characteristics of macrophages influence their phenotype and function, with pro-inflammatory M1 macrophages relying on glycolysis and anti-inflammatory M2 macrophages more dependent on mitochondrial OXPHOS.
BIOMARKER RESEARCH
(2021)
Editorial Material
Biochemistry & Molecular Biology
Belinda B. Garana, Nicholas A. Graham
Summary: Accurately identifying candidate drugs for protein targets is crucial for drug discovery. Chemical screening remains challenging, and misidentification of drug-target interactions can lead to failures in drug development. The use of high-throughput metabolomics to identify drug-target interactions demonstrates a promising new approach towards predicting drug-target relationships.
MOLECULAR SYSTEMS BIOLOGY
(2022)
Article
Anesthesiology
Srdjan Jelacic, Andrew Bowdle, Sai Krishna Madhavaram, Belinda B. Garana
Summary: Commercially available bite blocks used for invasive imaging procedures have limitations, so we designed a novel bite block to address these limitations. Evaluation results showed that most imagers preferred the redesigned bite block.