A model for the intrinsic limit of cancer therapy: Duality of treatment-induced cell death and treatment-induced stemness

Quantification of the Selective Advantage of Driver Mutations Is Dependent on the Underlying Model and Stage of Tumor Evolution

(2022) Ivana Bozic   CANCER RESEARCH

Normal tissue architecture determines the evolutionary course of cancer

(2021) Jeffrey West et al.   Nature Communications

Cycling cancer persister cells arise from lineages with distinct programs

(2021) Yaara Oren et al.   NATURE

Towards Multidrug Adaptive Therapy

(2020) Jeffrey West et al.   CANCER RESEARCH

Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation

(2020) Renee Brady-Nicholls et al.   Nature Communications

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

(2020) Nemanja Despot Marjanovic et al.   CANCER CELL

Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors

(2020) Sydney M. Shaffer et al.   CELL

Mathematical Details on a Cancer Resistance Model

(2020) James M. Greene et al.   Frontiers in Bioengineering and Biotechnology

Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet

(2020) Emilia Kozłowska et al.   PLoS Computational Biology

Ensembles, dynamics, and cell types: Revisiting the statistical mechanics perspective on cellular regulation

(2019) Stefan Bornholdt et al.   JOURNAL OF THEORETICAL BIOLOGY

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges

(2019) Mario L. Suvà et al.   MOLECULAR CELL

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies

(2018) Jill A. Gallaher et al.   CANCER RESEARCH

Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer

(2018) Emilia Kozłowska et al.   CANCER RESEARCH

Capitalizing on competition: An evolutionary model of competitive release in metastatic castration resistant prostate cancer treatment

(2018) Jeffrey West et al.   JOURNAL OF THEORETICAL BIOLOGY

Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI

(2018) Chien-Hui Weng et al.   ONCOGENE

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy

(2018) Ankur Sharma et al.   Nature Communications

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance

(2017) Yapeng Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: ‘What does not kill me strengthens me’

(2015) A O Pisco et al.   BRITISH JOURNAL OF CANCER

Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway

(2015) Tsai-Hsien Hung et al.   Oncotarget

Phenotype Switching: Tumor Cell Plasticity as a Resistance Mechanism and Target for Therapy

(2014) K. Kemper et al.   CANCER RESEARCH

Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells

(2013) Sui Huang   CANCER AND METASTASIS REVIEWS

Non-Darwinian dynamics in therapy-induced cancer drug resistance

(2013) Angela Oliveira Pisco et al.   Nature Communications

Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia

(2012) Stephany Corrêa et al.   BMC CANCER

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

(2012) Luis A. Diaz Jr et al.   NATURE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer

(2012) R. A. Beckman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy

(2011) A. F. Read et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Evolution of cancer survival analysis

(2010) Shunzo Maetani et al.   SURGICAL ONCOLOGY-OXFORD

Evolutionary Theory of Cancer

(2009) Camille Stephan-Otto Attolini et al.   Annals of the New York Academy of Sciences

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Progression-free survival and time to progression as primary end points in advanced breast cancer: often used, sometimes loosely defined

(2008) E. D. Saad et al.   ANNALS OF ONCOLOGY