The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization

Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours

(2022) A. S. Jijumon et al.   NATURE CELL BIOLOGY

Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

(2021) Xiaoyu Song et al.   Nature Chemical Biology

Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold

(2021) Nina Schweizer et al.   Nature Communications

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

(2020) Zhong Y. Yeow et al.   NATURE

Distinct retrograde microtubule motor sets drive early and late endosome transport

(2020) Giulia Villari et al.   EMBO JOURNAL

CCDC66 frameshift variant associated with a new form of early-onset progressive retinal atrophy in Portuguese Water Dogs

(2020) Leonardo Murgiano et al.   Scientific Reports

IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles

(2019) Nicolas Taulet et al.   Scientific Reports

Mapping the kinetochore MAP functions required for stabilizing microtubule attachments to chromosomes during metaphase

(2019) Mohammed A. Amin et al.   Cytoskeleton

Differential Requirements for Centrioles in Mitotic Centrosome Growth and Maintenance

(2019) Gabriela Cabral et al.   DEVELOPMENTAL CELL

Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors

(2019) Deniz Conkar et al.   Scientific Reports

A guide to classifying mitotic stages and mitotic defects in fixed cells

(2018) Nicolaas C. Baudoin et al.   CHROMOSOMA

Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis

(2018) Vladimir Joukov et al.   Science Signaling

Imaging cellular ultrastructures using expansion microscopy (U-ExM)

(2018) Davide Gambarotto et al.   NATURE METHODS

Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles

(2017) Iva M. Tolić   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Regulation of spindle integrity and mitotic fidelity by BCCIP

(2017) S C Huhn et al.   ONCOGENE

Mechanisms of Mitotic Spindle Assembly

(2016) Sabine Petry   Annual Review of Biochemistry

Mitosis

(2016) J. Richard McIntosh   Cold Spring Harbor Perspectives in Biology

Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor

(2016) Li Tao et al.   Nature Communications

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2

(2015) Hiroshi Hanafusa et al.   NATURE CELL BIOLOGY

Microtubule nucleation at the centrosome and beyond

(2015) Sabine Petry et al.   NATURE CELL BIOLOGY

Control of microtubule organization and dynamics: two ends in the limelight

(2015) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytokinesis in Animal Cells

(2015) Pier Paolo D’Avino et al.   Cold Spring Harbor Perspectives in Biology

Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication

(2014) Elif Nur Firat-Karalar et al.   CURRENT BIOLOGY

The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation

(2014) Paul T. Conduit et al.   DEVELOPMENTAL CELL

Mechanisms of spindle positioning: cortical force generators in the limelight

(2013) Sachin Kotak et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular pathways regulating mitotic spindle orientation in animal cells

(2013) M. S. Lu et al.   DEVELOPMENT

Aurora A kinase and its substrate TACC3 are required for central spindle assembly

(2013) Antonios Lioutas et al.   EMBO REPORTS

Cell Cycle Regulation of Microtubule Interactomes: Multi-layered Regulation Is Critical for the Interphase/Mitosis Transition

(2013) Heather M. Syred et al.   MOLECULAR & CELLULAR PROTEOMICS

A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum

(2013) Nathan C Shaner et al.   NATURE METHODS

Midbody assembly and its regulation during cytokinesis

(2012) Chi-Kuo Hu et al.   MOLECULAR BIOLOGY OF THE CELL

The amorphous pericentriolar cloud takes shape

(2012) Jens Lüders   NATURE CELL BIOLOGY

50 ways to build a spindle: the complexity of microtubule generation during mitosis

(2011) Tommy Duncan et al.   CHROMOSOME RESEARCH

A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging

(2011) Daniel G Booth et al.   EMBO JOURNAL

Ccdc66 null mutation causes retinal degeneration and dysfunction

(2011) Wanda M. Gerding et al.   HUMAN MOLECULAR GENETICS

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms

(2011) J. M. Schroder et al.   JOURNAL OF CELL SCIENCE

Functional analysis of the microtubule-interacting transcriptome

(2011) Judith A. Sharp et al.   MOLECULAR BIOLOGY OF THE CELL

The cilia protein IFT88 is required for spindle orientation in mitosis

(2011) Benedicte Delaval et al.   NATURE CELL BIOLOGY

A Minimal Midzone Protein Module Controls Formation and Length of Antiparallel Microtubule Overlaps

(2010) Peter Bieling et al.   CELL

Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein

(2010) Radhika Subramanian et al.   CELL

Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase

(2010) Ryota Uehara et al.   JOURNAL OF CELL BIOLOGY

CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex

(2010) Yuk-Kwan Choi et al.   JOURNAL OF CELL BIOLOGY

Chromosome segregation machinery and cancer

(2009) Kozo Tanaka et al.   CANCER SCIENCE

Force and Length in the Mitotic Spindle

(2009) Sophie Dumont et al.   CURRENT BIOLOGY

HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity

(2009) Steffen Lawo et al.   CURRENT BIOLOGY

Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene

(2009) Gabriele Dekomien et al.   NEUROGENETICS

The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells

(2009) R. Uehara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

(2008) Alexander W. Bird et al.   JOURNAL OF CELL BIOLOGY

Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle

(2008) Gohta Goshima et al.   JOURNAL OF CELL BIOLOGY

The 3Ms of central spindle assembly: microtubules, motors and MAPs

(2008) Michael Glotzer   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila

(2008) Jeroen Dobbelaere et al.   PLOS BIOLOGY