Localized pmrB hypermutation drives the evolution of colistin heteroresistance

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A mutational hotspot that determines highly repeatable evolution can be built and broken by silent genetic changes

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Colistin Heteroresistance in Klebsiella Pneumoniae Isolates and Diverse Mutations of PmrAB and PhoPQ in Resistant Subpopulations

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Identifying and exploiting genes that potentiate the evolution of antibiotic resistance

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Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin inSalmonella enterica

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Antibiotic treatment enhances the genome-wide mutation rate of target cells

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The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

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Evolved resistance to colistin and its loss due to genetic reversion in Pseudomonas aeruginosa

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