Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells

PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes

(2022) Joji Nagasaki et al.   Cell Reports

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Glucose makes Treg lose their temper

(2021) Matteo Villa et al.   CANCER CELL

Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition

(2021) Catherine Vander Linden et al.   Cell Reports

Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

(2020) Jinhua Li et al.   EMBO REPORTS

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4+ T Cells

(2019) Saleh et al.   Vaccines

Histone Lactylation: A New Role for Glucose Metabolism

(2019) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

(2018) Xuhao Ni et al.   Cancer Discovery

Intratumor lactate levels reflect HER2 addiction status in HER2-positive breast cancer

(2018) Lorenzo Castagnoli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Clinical, Immunological, and Molecular Heterogeneity of 173 Patients With the Phenotype of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome

(2018) Eleonora Gambineri et al.   Frontiers in Immunology

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

(2017) Frederick Arce Vargas et al.   IMMUNITY

Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways

(2017) Anthony Joetham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling

(2017) Ephraim A. Ansa-Addo et al.   JOURNAL OF CLINICAL INVESTIGATION

Lactic Acid: No Longer an Inert and End-Product of Glycolysis

(2017) Shiren Sun et al.   PHYSIOLOGY

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years

(2016) Sebastian Blatt et al.   Clinical Oral Investigations

FOXP3+ regulatory T cells and their functional regulation

(2015) Zhiyuan Li et al.   Cellular & Molecular Immunology

iTreg induced from CD39+ naive T cells demonstrate enhanced proliferate and suppressive ability

(2015) Yunjie Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In Vivo-Generated Antigen-Specific Regulatory T Cells Treat Autoimmunity Without Compromising Antibacterial Immune Response

(2014) S. Kasagi et al.   Science Translational Medicine

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

(2013) D. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

(2012) Pengyuan Yang et al.   CANCER CELL

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

(2009) Marcin Kortylewski et al.   CANCER CELL