Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAPK/ERK signaling

ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood-brain-barrier modulation

(2021) Limin Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

MicroRNA-133a Regulates the Viability and Differentiation Fate of Bone Marrow Mesenchymal Stem Cells via MAPK/ERK Signaling Pathway by Targeting FGFR1

(2021) Gang Wang et al.   DNA AND CELL BIOLOGY

Genetics of diabetes mellitus and diabetes complications

(2020) Joanne B. Cole et al.   Nature Reviews Nephrology

Potential therapeutic effects of endothelial cells trans-differentiated from Wharton’s Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model

(2020) Shaimaa M. Motawea et al.   Diabetology & Metabolic Syndrome

METTL1 limits differentiation and functioning of EPCs derived from human-induced pluripotent stem cells through a MAPK/ERK pathway

(2020) Yujie Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cotransplantation of human umbilical cord mesenchymal stem cells and endothelial cells for angiogenesis and pulp regeneration in vivo

(2020) Shuang Zhang et al.   LIFE SCIENCES

Endothelial Dysfunction in Diabetic Retinopathy

(2020) Fu Gui et al.   Frontiers in Endocrinology

Arterialization requires the timely suppression of cell growth

(2020) Wen Luo et al.   NATURE

Stem cells: past, present, and future

(2019) Wojciech Zakrzewski et al.   Stem Cell Research & Therapy

Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism

(2019) Li Ling et al.   Stem Cell Research & Therapy

Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling

(2019) Milad Bitar   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stem Cell Migration and Tissue Repair

(2019) Fu et al.   Cells

Traditional two-dimensional mesenchymal stem cells (MSCs) are better than spheroid MSCs on promoting retinal ganglion cells survival and axon regeneration

(2019) Wei Huang et al.   EXPERIMENTAL EYE RESEARCH

Epigenetic regulation in diabetic vascular complications

(2019) Jiayu Jin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Menstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases

(2019) Lijun Chen et al.   Stem Cell Research & Therapy

Vascular endothelial growth factor over-expressed mesenchymal stem cells-conditioned media ameliorate palmitate-induced diabetic endothelial dysfunction through PI-3K/AKT/m-TOR/eNOS and p38/MAPK signaling pathway

(2018) Tianwei Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Mesenchymal stromal/stem cells as potential therapy in diabetic retinopathy

(2018) Agnese Fiori et al.   IMMUNOBIOLOGY

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications

(2018) Bou-Yue Peng et al.   Journal of Diabetes Research

Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy

(2018) Wuzheng Zhu et al.   Cell Death & Disease

Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway

(2018) Yu Xiao et al.   BIOMEDICINE & PHARMACOTHERAPY

Nano-medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies

(2018) Gaurav Taneja et al.   Cardiovascular Toxicology

Overexpression of ERBB4 rejuvenates aged mesenchymal stem cell and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathway

(2018) Xiaoting Liang et al.   FASEB JOURNAL

Regulation of fibroblast growth factor 8 (FGF8 ) in chicken embryonic stem cells differentiation into spermatogonial stem cells

(2017) Man Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Macro- and microvascular endothelial dysfunction in diabetes

(2017) Yi Shi et al.   Journal of Diabetes

Vascular Complications of Diabetes

(2016) Joshua A. Beckman et al.   CIRCULATION RESEARCH

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1  pathway

(2016) Y. Yuan et al.   CLINICAL SCIENCE

Diabetic nephropathy and endothelial dysfunction: Current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study

(2016) Wilson KC Leung et al.   LIFE SCIENCES

miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer

(2016) Xiao Wang et al.   Cell Death & Disease

C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways

(2016) JiaYuan Chen et al.   Stem Cell Research & Therapy

Fabrication of hydroxyapatite/chitosan composite hydrogels loaded with exosomes derived from miR-126-3p overexpressed synovial mesenchymal stem cells for diabetic chronic wound healing

(2016) Min Li et al.   Journal of Materials Chemistry B

Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes

(2016) Kanna Nagaishi et al.   Scientific Reports

TGF-β3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling

(2015) Yiqing Tao et al.   GROWTH FACTORS

Human mesenchymal stem cells enhance cancer cell proliferation via IL-6 secretion and activation of ERK1/2

(2015) AGMAL SCHERZAD et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice

(2015) Mingjun Cao et al.   Stem Cell Research & Therapy

Hypoxia Pretreatment of Bone Marrow Mesenchymal Stem Cells Facilitates Angiogenesis by Improving the Function of Endothelial Cells in Diabetic Rats with Lower Ischemia

(2015) Jiejie Liu et al.   PLoS One

Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes

(2015) Hui-Hung Tzeng et al.   PLoS One

Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis

(2014) Annelies Bronckaers et al.   PHARMACOLOGY & THERAPEUTICS

Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation

(2014) Avraham Maimon et al.   Cell Reports

Saturated fatty acid palmitate induces extracellular release of histone H3: A possible mechanistic basis for high-fat diet-induced inflammation and thrombosis

(2013) Chandan Shrestha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of miR-126 promotes the differentiation of mesenchymal stem cells toward endothelial cells via activation of PI3K/Akt and MAPK/ERK pathways and release of paracrine factors

(2013) Feng Huang et al.   BIOLOGICAL CHEMISTRY

Basic Fibroblast Growth Factor (bFGF) Facilitates Differentiation of Adult Dorsal Root Ganglia-Derived Neural Stem Cells Toward Schwann Cells by Binding to FGFR-1 Through MAPK/ERK Activation

(2013) Yun Gu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Long term effects of the implantation of Wharton^|^rsquo;s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus

(2012) Jianxia Hu et al.   ENDOCRINE JOURNAL

Unique Responses of Stem Cell-Derived Vascular Endothelial and Mesenchymal Cells to High Levels of Glucose

(2012) Emily Keats et al.   PLoS One

The MSC: An Injury Drugstore

(2011) Arnold I. Caplan et al.   Cell Stem Cell

Herbal Medicines and Nutraceuticals for Diabetic Vascular Complications: Mechanisms of Action and Bioactive Phytochemicals

(2011) Eshaifol A. Omara et al.   CURRENT PHARMACEUTICAL DESIGN

Endothelial Dysfunction in Diabetes: The role of reparatory mechanisms

(2011) A. Avogaro et al.   DIABETES CARE

Pyridoxal 5′ phosphate protects islets against streptozotocin-induced beta-cell dysfunction – in vitro and in vivo

(2011) Sashi G Kiran et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway

(2011) Hui Theng Gan et al.   JOURNAL OF NEUROCHEMISTRY

Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure

(2010) T. N. Phoenix et al.   GENES & DEVELOPMENT

VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells

(2009) Sofia Bellou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell

(2008) J. Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Paracrine action mediate the antifibrotic effect of transplanted mesenchymal stem cells in a rat model of global heart failure

(2008) Lili Li et al.   MOLECULAR BIOLOGY REPORTS

Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes

(2008) William Duckworth et al.   NEW ENGLAND JOURNAL OF MEDICINE