Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta

New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease

(2022) Leslye Venegas-Zamora et al.   Frontiers in Genetics

Syncytins expressed in human placental trophoblast

(2021) R. Michael Roberts et al.   PLACENTA

Molecular and immunological developments in placentas

(2021) Akitoshi Nakashima et al.   HUMAN IMMUNOLOGY

Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?

(2021) Jun Sugimoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transposable elements shape the evolution of mammalian development

(2021) Anna D. Senft et al.   NATURE REVIEWS GENETICS

Alzheimer's disease associated with Down syndrome: a genetic form of dementia

(2021) Juan Fortea et al.   LANCET NEUROLOGY

A re-examination of the origins of placental bed giant cells

(2021) Carolyn J.P. Jones et al.   PLACENTA

Trophoblast invasion: Lessons from abnormally invasive placenta (placenta accreta)

(2020) Nicholas P. Illsley et al.   PLACENTA

Down Syndrome

(2020) Marilyn J. Bull   NEW ENGLAND JOURNAL OF MEDICINE

Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation

(2019) Jun Sugimoto et al.   Scientific Reports

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

(2018) Frances K Wiseman et al.   BRAIN

Syncytin-1, an endogenous retroviral protein, triggers the activation of CRP via TLR3 signal cascade in glial cells

(2018) Xiuling Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 are effective in in vivo models of schizophrenia and visual dysfunction

(2018) Yong-Xin Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells

(2018) Berna Uygur et al.   MOLECULAR CANCER RESEARCH

Expression and function of endogenous retroviruses in the placenta

(2016) Joachim Denner   APMIS

Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits and challenges

(2016) Trilochan Sahoo et al.   GENETICS IN MEDICINE

Baton pass hypothesis: successive incorporation of unconserved endogenous retroviral genes for placentation during mammalian evolution

(2015) Kazuhiko Imakawa et al.   GENES TO CELLS

Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo

(2015) Sebastian Frese et al.   PLoS One

Current Estimate of Down Syndrome Population Prevalence in the United States

(2013) Angela P. Presson et al.   JOURNAL OF PEDIATRICS

Reduced Syncytin-1 Expression Levels in Placental Syndromes Correlates with Epigenetic Hypermethylation of the ERVW-1 Promoter Region

(2013) Matthias Ruebner et al.   PLoS One

A novel human endogenous retroviral protein inhibits cell-cell fusion

(2013) Jun Sugimoto et al.   Scientific Reports

Review: Human trophoblast fusion and differentiation: Lessons from trisomy 21 placenta

(2011) G. Pidoux et al.   PLACENTA

Age- and Disease-Dependent HERV-W Envelope Allelic Variation in Brain: Association with Neuroimmune Gene Expression

(2011) Rakesh K. Bhat et al.   PLoS One

A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast

(2011) A. Dupressoir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gestational trophoblastic disease

(2010) Michael J Seckl et al.   LANCET

Trisomy 21- affected placentas highlight prerequisite factors for human trophoblast fusion and differentiation

(2009) Andre Malassine et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Review: Human Endogenous Retroviruses and the Placenta

(2009) Jun Sugimoto et al.   Reproductive Sciences

Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain

(2008) Catherine M. Gliddon et al.   JOURNAL OF NEUROCHEMISTRY

Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta

(2008) Andre Malassine et al.   Retrovirology

First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics

(2008) K. O. Kagan et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY