Predicting cancer immunotherapy response from gut microbiomes using machine learning models

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

(2022) John A. McCulloch et al.   NATURE MEDICINE

The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology

(2021) Jinuk Jeong et al.   Scientific Reports

A uniform computational approach improved on existing pipelines to reveal microbiome biomarkers of non-response to immune checkpoint inhibitors

(2021) Fyza Y Shaikh et al.   CLINICAL CANCER RESEARCH

Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

(2021) Francesco Beghini et al.   eLife

Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies

(2021) Paul Oster et al.   GUT

Integrative analysis of gut microbiome and host transcriptomes reveals associations between treatment outcomes and immunotherapy‐induced colitis

(2021) Toshiharu Sakurai et al.   Molecular Oncology

An Exploratory Study for the Association of Gut Microbiome with Efficacy of Immune Checkpoint Inhibitor in Patients with Hepatocellular Carcinoma

(2021) Ying-Chun Shen et al.   Journal of Hepatocellular Carcinoma

Gut microbial species and metabolic pathways associated with response to treatment with immune checkpoint inhibitors in metastatic melanoma

(2020) Thijs T. Wind et al.   MELANOMA RESEARCH

Predictable modulation of cancer treatment outcomes by the gut microbiota

(2020) Yoshitaro Heshiki et al.   Microbiome

Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients

(2020) Lisa Derosa et al.   EUROPEAN UROLOGY

Relationship between intestinal flora structure and metabolite analysis and immunotherapy efficacy in Chinese NSCLC patients

(2020) Peng Song et al.   Thoracic Cancer

Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti–PD-1 Immune Checkpoint Inhibitors

(2020) Nicholas J. Salgia et al.   EUROPEAN UROLOGY

Characterization of gut microbiota in patients with primary hepatocellular carcinoma received immune checkpoint inhibitors

(2020) Lili LI et al.   MEDICINE

The Gut Microbiome Is Associated with Clinical Response to Anti–PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer

(2020) Zhi Peng et al.   Cancer Immunology Research

The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non–Small Cell Lung Cancer

(2020) Taiki Hakozaki et al.   Cancer Immunology Research

Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma

(2020) Angelo Limeta et al.   JCI Insight

Genomic correlates of response to immune checkpoint blockade

(2019) Tanya E. Keenan et al.   NATURE MEDICINE

The diversity of gut microbiome is associated with favorable responses to anti-PD-1 immunotherapy in Chinese non-small cell lung cancer patients

(2019) Yueping Jin et al.   Journal of Thoracic Oncology

Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma

(2019) Yi Zheng et al.   Journal for ImmunoTherapy of Cancer

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2019) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis

(2019) Jethro S. Johnson et al.   Nature Communications

Relating the gut metagenome and metatranscriptome to immunotherapy responses in melanoma patients

(2019) Brandilyn A. Peters et al.   Genome Medicine

Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer

(2018) L Derosa et al.   ANNALS OF ONCOLOGY

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

(2018) Laurence Zitvogel et al.   SCIENCE

Impact of antibiotic treatment on immune-checkpoint blockade efficacy in advanced non-squamous non-small cell lung cancer

(2018) Florian Huemer et al.   Oncotarget

Balances: a New Perspective for Microbiome Analysis

(2018) J. Rivera-Pinto et al.   mSystems

Microbiota and cancer immunotherapy: in search of microbial signals

(2018) Raad Z Gharaibeh et al.   GUT

Immune correlates of clinical outcome in melanoma

(2017) Graham Pawelec   IMMUNOLOGY

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients

(2017) Arthur E. Frankel et al.   NEOPLASIA

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Short-Term Effect of Antibiotics on Human Gut Microbiota

(2014) Suchita Panda et al.   PLoS One

Ribosomal Database Project: data and tools for high throughput rRNA analysis

(2013) James R. Cole et al.   NUCLEIC ACIDS RESEARCH

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE