Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis

Macropinocytosis in Cancer-Associated Fibroblasts is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness

(2021) Yijuan Zhang et al.   Cancer Discovery

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

The origins and evolution of macropinocytosis

(2018) Jason S. King et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identification of laminin α 5 short arm peptides active for endothelial cell attachment and tube formation

(2017) Yamato Kikkawa et al.   JOURNAL OF PEPTIDE SCIENCE

New Directions in Anti-Angiogenic Therapy for Glioblastoma

(2017) Nancy Wang et al.   Neurotherapeutics

Cell behaviors and dynamics during angiogenesis

(2016) Charles Betz et al.   DEVELOPMENT

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo

(2016) Véronique Gebala et al.   NATURE CELL BIOLOGY

Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis

(2016) Sara Caviglia et al.   NATURE CELL BIOLOGY

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

(2016) Johnathan Canton et al.   Nature Communications

Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins

(2015) H. Yu et al.   DEVELOPMENT

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study

(2015) L. Burt Nabors et al.   NEURO-ONCOLOGY

CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion

(2015) Pengcheng Zhou et al.   Oncotarget

Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis

(2015) Maikel A. Farhan et al.   PLoS One

In situ Ca2+ titration in the fluorometric study of intracellular Ca2+ binding

(2014) Shane M. McMahon et al.   CELL CALCIUM

Antiangiogenic Therapy for Glioblastoma: Current Status and Future Prospects

(2014) T. T. Batchelor et al.   CLINICAL CANCER RESEARCH

Revisiting the matricellular concept

(2014) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

Determining the macropinocytic index of cells through a quantitative image-based assay

(2014) Cosimo Commisso et al.   Nature Protocols

Molecular mechanisms of de novo lumen formation

(2014) Sara Sigurbjörnsdóttir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

Modeling Adult Gliomas Using RCAS/t-va Technology

(2014) Dolores Hambardzumyan et al.   Translational Oncology

The Biogenesis of Lysosomes and Lysosome-Related Organelles

(2014) J. P. Luzio et al.   Cold Spring Harbor Perspectives in Biology

Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells

(2012) C. Giampietro et al.   BLOOD

TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types

(2012) Amit Chaudhary et al.   CANCER CELL

Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin  6 1 in Glioblastoma

(2012) P. Huang et al.   CANCER RESEARCH

Transdifferentiation of Glioblastoma Stem-Like Cells into Mural Cells Drives Vasculogenic Mimicry in Glioblastomas

(2012) S. Scully et al.   JOURNAL OF NEUROSCIENCE

The disturbed blood–brain barrier in human glioblastoma

(2012) Hartwig Wolburg et al.   MOLECULAR ASPECTS OF MEDICINE

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration

(2011) Zhizhan Gu et al.   JOURNAL OF CELL BIOLOGY

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Endothelial α3β1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGF

(2010) Rita Graça da Silva et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis

(2010) Stephanie L. Gupton et al.   DEVELOPMENTAL CELL

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

(2010) Ann C. Zovein et al.   DEVELOPMENTAL CELL

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

The Pathobiology of Glioma Tumors

(2009) Candece L. Gladson et al.   Annual Review of Pathology-Mechanisms of Disease

VE-Cadherin-Mediated Cell-Cell Interaction Suppresses Sprouting via Signaling to MLC2 Phosphorylation

(2009) Sabu Abraham et al.   CURRENT BIOLOGY

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

(2009) Boris Strilić et al.   DEVELOPMENTAL CELL

Formation of endothelial lumens requires a coordinated PKC -, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation

(2009) W. Koh et al.   JOURNAL OF CELL SCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151

(2008) Andries Zijlstra et al.   CANCER CELL

Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo

(2008) Yannick Blum et al.   DEVELOPMENTAL BIOLOGY

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling

(2008) W. Koh et al.   JOURNAL OF CELL SCIENCE

Ca2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse

(2008) Hiroyuki Kabayama et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH