MHC Class I Enables MSCs to Evade NK-Cell–Mediated Cytotoxicity and Exert Immunosuppressive Activity

Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy

(2021) Yu Fu et al.   Cell Death & Disease

Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells

(2020) Huan Liu et al.   Autophagy

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

(2019) Simona Sivori et al.   Cellular & Molecular Immunology

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

TNF-α/IL-1β–licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell–mediated induction of Foxp3+ regulatory T cells in the lung

(2019) Nick Murphy et al.   FASEB JOURNAL

Mesenchymal stem versus stromal cells: International Society for Cellular Therapy Mesenchymal Stromal Cell committee position statement on nomenclature

(2019) S. Viswanathan et al.   CYTOTHERAPY

The Importance of HLA Assessment in “Off-the-Shelf” Allogeneic Mesenchymal Stem Cells Based-Therapies

(2019) Marta Kot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An acute immune response underlies the benefit of cardiac stem-cell therapy

(2019) Ronald J. Vagnozzi et al.   NATURE

CD8 + T cells and NK cells: parallel and complementary soldiers of immunotherapy

(2018) Jillian Rosenberg et al.   Current Opinion in Chemical Engineering

Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs

(2017) Darwin J. Prockop et al.   MOLECULAR THERAPY

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

(2017) Antonio Galleu et al.   Science Translational Medicine

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis

(2017) Taeko Shigemoto-Kuroda et al.   Stem Cell Reports

Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart

(2016) Xi-Ping Huang et al.   FASEB JOURNAL

Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs

(2016) Nikolay Bazhanov et al.   Stem Cell Research & Therapy

Mesenchymal Stem/Stromal Cells Protect against Autoimmunity via CCL2-Dependent Recruitment of Myeloid-Derived Suppressor Cells

(2015) Hyun Ju Lee et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye

(2015) Jung Hwa Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells

(2015) Dachun Wang et al.   Stem Cells Translational Medicine

Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1

(2015) Vanessa Kruse et al.   PLoS One

Mesenchymal stem cells: immune evasive, not immune privileged

(2014) James A Ankrum et al.   NATURE BIOTECHNOLOGY

TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo

(2014) Ryang Hwa Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells

(2014) Justine Allard et al.   Regenerative Medicine

Heterelogous expression of mutated HLA-G decreases immunogenicity of human embryonic stem cells and their epidermal derivatives

(2014) Longmei Zhao et al.   Stem Cell Research

Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1)

(2013) Thomas J. Bartosh et al.   STEM CELLS

Mesenchymal Stem Cell Lines Isolated by Different Isolation Methods Show Variations in the Regulation of Graft-versus-host Disease

(2013) Hyun Seung Yoo et al.   Immune Network

Modulation of Human Mesenchymal Stem Cell Immunogenicity through Forced Expression of Human Cytomegalovirus US Proteins

(2012) Melisa A. Soland et al.   PLoS One

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF- B signaling in resident macrophages

(2011) H. Choi et al.   BLOOD

Human Leukocyte Antigen I Knockdown Human Embryonic Stem Cells Induce Host Ignorance and Achieve Prolonged Xenogeneic Survival

(2011) T. Deuse et al.   CIRCULATION

Therapeutic factors secreted by mesenchymal stromal cells and tissue repair

(2011) Ryang Hwa Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exploitation of Herpesvirus Immune Evasion Strategies to Modify the Immunogenicity of Human Mesenchymal Stem Cell Transplants

(2011) Anabel S. de la Garza-Rodea et al.   PLoS One

Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells

(2010) Chiara Bocelli-Tyndall et al.   ARTHRITIS AND RHEUMATISM

Differentiation of Allogeneic Mesenchymal Stem Cells Induces Immunogenicity and Limits Their Long-Term Benefits for Myocardial Repair

(2010) Xi-Ping Huang et al.   CIRCULATION

Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells

(2010) Ralf Dressel et al.   FASEB JOURNAL

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

(2010) T. J. Bartosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Natural killer cells remember: An evolutionary bridge between innate and adaptive immunity?

(2009) Joseph C. Sun et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The CD34-like protein PODXL and  6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice

(2008) R. H. Lee et al.   BLOOD