Mitochondrial remodeling and ischemic protection by G protein–coupled receptor 35 agonists

Arrestin-dependent and -independent internalization of GPCRs - methods, mechanisms and implications on cell signaling

(2021) Ee Von Moo et al.   MOLECULAR PHARMACOLOGY

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

(2021) Edward L. Huttlin et al.   CELL

Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice

(2020) Rooban B. Nahomi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice

(2020) Hiroko Deguchi et al.   CIRCULATION JOURNAL

Inhibition of GPR35 Preserves Mitochondrial Function after Myocardial Infarction by Targeting Calpain 1/2

(2020) Ken Chen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria

(2020) Yael Elbaz-Alon et al.   Nature Communications

Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages

(2020) Ozayra Sharmin et al.   Scientific Reports

Functional Metabolomics Reveal the Role of AHR/GPR35 Mediated Kynurenic acid Gradient Sensing in Chemotherapy-induced Intestinal Damage

(2020) Di Wang et al.   Acta Pharmaceutica Sinica B

Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis

(2020) László Juhász et al.   Frontiers in Medicine

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

(2019) Georg Schneditz et al.   Science Signaling

Mitochondrial interaction with the endosomal compartment in endocytosis and mitochondrial transfer

(2019) Kiran Todkar et al.   MITOCHONDRION

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

(2018) Leandro Z. Agudelo et al.   Cell Metabolism

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria

(2018) FoSheng Hsu et al.   eLife

A Review of the Inhibition of the Mitochondrial ATP Synthase by IF1 in vivo: Reprogramming Energy Metabolism and Inducing Mitohormesis

(2018) Ana García-Aguilar et al.   Frontiers in Physiology

When trafficking and signaling mix: how subcellular location shapes GPCR activation of heterotrimeric G proteins

(2018) Braden T. Lobingier et al.   TRAFFIC

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

(2017) Tzu-Lan Yeh et al.   Chemical Science

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation

(2017) Victoria Hung et al.   eLife

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

(2017) Chirag Vasavda et al.   Jove-Journal of Visualized Experiments

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

(2016) Benjamin A. Olenchock et al.   CELL

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation

(2016) Francesco Resta et al.   NEUROPHARMACOLOGY

Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration

(2016) Rita Valenzuela et al.   Cell Death & Disease

APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest

(2016) Song-Yi Lee et al.   Cell Reports

cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants

(2016) Lorena Olivares-González et al.   PLoS One

Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery

(2015) Derek J. Hausenloy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult

(2015) Melanie Vogler et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H+-ATP Synthase

(2015) Javier García-Bermúdez et al.   Cell Reports

The compound BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase

(2014) Fabrice Ivanes et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning

(2014) L. Formentini et al.   EMBO JOURNAL

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

(2014) Hui Yang et al.   Nature Protocols

Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling

(2013) Veli-Pekka Ronkainen et al.   CARDIOVASCULAR RESEARCH

Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor

(2013) Pingwei Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small and large animal models in cardiac contraction research: Advantages and disadvantages

(2013) Nima Milani-Nejad et al.   PHARMACOLOGY & THERAPEUTICS

The continuing evolution of the Langendorff and ejecting murine heart: new advances in cardiac phenotyping

(2012) Ronglih Liao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Assessing Actual Contribution of IF1, Inhibitor of Mitochondrial FoF1, to ATP Homeostasis, Cell Growth, Mitochondrial Morphology, and Cell Viability

(2012) Makoto Fujikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia

(2011) Levente Gellért et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury

(2011) Marion Hölscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orthologue selectivity and ligand bias: translating the pharmacology of GPR35

(2011) Graeme Milligan   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of genes related to heart failure using global gene expression profiling of human failing myocardium

(2010) Kyung-Duk Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β-arrestin-2

(2010) Laura Jenkins et al.   BRITISH JOURNAL OF PHARMACOLOGY

Up-regulation of the ATPase Inhibitory Factor 1 (IF1) of the Mitochondrial H+-ATP Synthase in Human Tumors Mediates the Metabolic Shift of Cancer Cells to a Warburg Phenotype

(2010) Laura Sánchez-Cenizo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat

(2010) Weike Bao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and  -Arrestin2 with Antinociceptive Activity

(2010) P. Zhao et al.   MOLECULAR PHARMACOLOGY

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion

(2010) Juan Zhang et al.   Nature Communications

Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels

(2009) M.H. Selina Mok et al.   NEUROPHARMACOLOGY

Injection of isolated mitochondria during early reperfusion for cardioprotection

(2008) James D. McCully et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Kynurenic acid attenuates MPP+-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway

(2008) Do Yeon Lee et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Gα12 is targeted to the mitochondria and affects mitochondrial morphology and motility

(2008) Alexandra V. Andreeva et al.   FASEB JOURNAL