Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

(2021) Wing K. Man et al.   Nature Communications

A Master Regulator of α-Synuclein Aggregation

(2020) Timir Tripathi   ACS Chemical Neuroscience

A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

(2020) Ciaran P. A. Doherty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly

(2020) Oscar Palomino-Hernandez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

(2020) Kun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins

(2020) Michele F. Sciacca et al.   ACS Chemical Neuroscience

Keeping α-Synuclein at Bay: A More Active Role of Molecular Chaperones in Preventing Mitochondrial Interactions and Transition to Pathological States?

(2020) Emelie E. Aspholm et al.   Life-Basel

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation

(2018) Ariel A. Valiente-Gabioud et al.   BIOPHYSICAL JOURNAL

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

(2018) Caterina Masaracchia et al.   Acta Neuropathologica Communications

Role of Parkinson’s Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde

(2018) Vanderlei de Araújo Lima et al.   ACS Chemical Neuroscience

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential

(2017) Saurav Brahmachari et al.   Journal of Parkinsons Disease

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations

(2016) Igor Dikiy et al.   ACS Chemical Biology

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis

(2015) Ritwik Burai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

(2015) Daniel Ysselstein et al.   NEUROBIOLOGY OF DISEASE

Multiple-System Atrophy

(2015) Alessandra Fanciulli et al.   NEW ENGLAND JOURNAL OF MEDICINE

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

(2014) Anne-Laure Mahul-Mellier et al.   HUMAN MOLECULAR GENETICS

Site-Specific Copper-Catalyzed Oxidation of α-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson’s Disease

(2014) Marco C. Miotto et al.   INORGANIC CHEMISTRY

Sequence and Membrane Determinants of the Random Coil–Helix Transition of α-Synuclein

(2014) Sowmya B. Lokappa et al.   JOURNAL OF MOLECULAR BIOLOGY

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

(2014) Luis Fonseca-Ornelas et al.   Nature Communications

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

(2014) Diana F. Lázaro et al.   PLoS Genetics

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

α-Synucleinopathy phenotypes

(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

Modeling Lewy pathology propagation in Parkinson's disease

(2013) Kelvin C. Luk et al.   PARKINSONISM & RELATED DISORDERS

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

(2012) Alexander S. Maltsev et al.   BIOCHEMISTRY

Toward the Discovery of Effective Polycyclic Inhibitors of α-Synuclein Amyloid Assembly

(2011) Gonzalo R. Lamberto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for the Glycosphingolipid-Binding Specificity of α-Synuclein: Key Role of Tyrosine 39 in Membrane Insertion

(2011) Jacques Fantini et al.   JOURNAL OF MOLECULAR BIOLOGY

Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding

(2011) Eva Sevcsik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Bioinorganic Chemistry of Parkinson’s Disease: Structural Determinants for the Copper-Mediated Amyloid Formation of Alpha-Synuclein

(2010) Andrés Binolfi et al.   INORGANIC CHEMISTRY

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   BIOCHEMISTRY

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

On the mechanism of internalization of α-synuclein into microglia: roles of ganglioside GM1 and lipid raft

(2009) Ji-Young Park et al.   JOURNAL OF NEUROCHEMISTRY

Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein

(2009) J.B. Watson et al.   NEUROSCIENCE

Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

(2009) Gonzalo R. Lamberto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE