Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates

(2018) Anne M. Reiner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates

(2018) Dario Valdinocci et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Developing a molecular dynamics force field for both folded and disordered protein states

(2018) Paul Robustelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates

(2018) Luana Palazzi et al.   Scientific Reports

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

(2018) Karima Schwab et al.   Frontiers in Molecular Neuroscience

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features

(2018) Iñaki Gentile et al.   Metallomics

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

(2018) Jordi Pujols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational-Switch Based Strategy Triggered by [18] π Heteroannulenes toward Reduction of Alpha Synuclein Oligomer Toxicity

(2018) Ritobrita Chakraborty et al.   ACS Chemical Neuroscience

Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

(2017) Florencia González-Lizárraga et al.   Scientific Reports

Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation

(2016) Ariel A. Valiente-Gabioud et al.   ACCOUNTS OF CHEMICAL RESEARCH

PDB2CD: a web-based application for the generation of circular dichroism spectra from protein atomic coordinates

(2016) Lazaros Mavridis et al.   BIOINFORMATICS

Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations

(2016) G. Rossetti et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis

(2015) Ritwik Burai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset

(2014) Johannes Levin et al.   ACTA NEUROPATHOLOGICA

A Relationship between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-Synuclein and β-Synuclein

(2014) Jane R. Allison et al.   BIOCHEMISTRY

Structures of the E46K Mutant-Type α-Synuclein Protein and Impact of E46K Mutation on the Structures of the Wild-Type α-Synuclein Protein

(2013) Olivia Wise-Scira et al.   ACS Chemical Neuroscience

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

PLUMED 2: New feathers for an old bird

(2013) Gareth A. Tribello et al.   COMPUTER PHYSICS COMMUNICATIONS

Treatment Strategies Targeting Amyloid  -Protein

(2013) D. Schenk et al.   Cold Spring Harbor Perspectives in Medicine

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

(2012) Alexander S. Maltsev et al.   BIOCHEMISTRY

Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

(2012) Tingyu Liu et al.   ChemMedChem

Generic inhibition of amyloidogenic proteins by two naphthoquinone-tryptophan hybrid molecules

(2012) Roni Scherzer-Attali et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide

(2011) Anat Frydman-Marom et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Toward the Discovery of Effective Polycyclic Inhibitors of α-Synuclein Amyloid Assembly

(2011) Gonzalo R. Lamberto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHIFTX2: significantly improved protein chemical shift prediction

(2011) Beomsoo Han et al.   JOURNAL OF BIOMOLECULAR NMR

Replica Exchange with Solute Scaling: A More Efficient Version of Replica Exchange with Solute Tempering (REST2)

(2011) Lingle Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

(2009) Gonzalo R. Lamberto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Tyr to Ala mutations on α-synuclein fibrillation and structural properties

(2008) Nataša Poklar Ulrih et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solvent-induced collapse of α-synuclein and acid-denatured cytochrome c

(2002) Artemiza S. Morar et al.   PROTEIN SCIENCE