Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria

(2021) Ane Landajuela et al.   PLOS BIOLOGY

Membrane constriction and thinning by sequential ESCRT-III polymerization

(2020) Henry C. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Anisotropic ESCRT-III architecture governs helical membrane tube formation

(2020) Joachim Moser von Filseck et al.   Nature Communications

Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation

(2020) Aurélie Bertin et al.   Nature Communications

An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission

(2020) Anna-Katharina Pfitzner et al.   CELL

Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes

(2020) John McCullough et al.   CURRENT BIOLOGY

Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4

(2019) Han Han et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

(2019) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

(2019) Han Han et al.   eLife

Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon

(2019) Javier Espadas et al.   Nature Communications

Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function

(2019) Rachel Allison et al.   Frontiers in Neuroscience

ESCRT-III is required for scissioning new peroxisomes from the endoplasmic reticulum

(2018) Fred D. Mast et al.   JOURNAL OF CELL BIOLOGY

Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers

(2018) Léa Ripoll et al.   JOURNAL OF CELL BIOLOGY

The ESCRT CHMP2B acts as a diffusion barrier on reconstituted membrane necks

(2018) Nicola De Franceschi et al.   JOURNAL OF CELL SCIENCE

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

(2018) Marco M Manni et al.   eLife

Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly

(2018) Daniel S Johnson et al.   eLife

Inside job: how the ESCRTs release HIV-1 from infected cells

(2018) James H. Hurley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Functional differences of short and long isoforms of spastin harboring missense mutation

(2018) Clément Plaud et al.   Disease Models & Mechanisms

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

Microtubule-severing enzymes: From cellular functions to molecular mechanism

(2018) Francis J. McNally et al.   JOURNAL OF CELL BIOLOGY

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4

(2018) Johannes Schöneberg et al.   SCIENCE

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

(2017) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

(2017) Beata E. Mierzwa et al.   NATURE CELL BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly

(2015) Il-Hyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and membrane remodeling activity of ESCRT-III helical polymers

(2015) J. McCullough et al.   SCIENCE

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly

(2014) Qing-Tao Shen et al.   JOURNAL OF CELL BIOLOGY

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis

(2014) Henri-François Renard et al.   NATURE

Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins

(2014) M. Pinot et al.   SCIENCE

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

(2013) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

ESCRT-III CHMP2A and CHMP3 form variable helical polymersin vitroand act synergistically during HIV-1 budding

(2012) Grégory Effantin et al.   CELLULAR MICROBIOLOGY

The AAA ATPase spastin links microtubule severing to membrane modelling

(2011) Jennifer H. Lumb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

(2011) Markus Babst   CURRENT OPINION IN CELL BIOLOGY

Activation of Human VPS4A by ESCRT-III Proteins Reveals Ability of Substrates to Relieve Enzyme Autoinhibition

(2010) Samuel A. Merrill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPG20 Protein Spartin Is Recruited to Midbodies by ESCRT-III Protein Ist1 and Participates in Cytokinesis

(2010) Benoît Renvoisé et al.   MOLECULAR BIOLOGY OF THE CELL

Essential Role of hIST1 in Cytokinesis

(2009) Monica Agromayor et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Curvature-driven lipid sorting needs proximity to a demixing point and is aided by proteins

(2009) B. Sorre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments

(2008) Phyllis I. Hanson et al.   JOURNAL OF CELL BIOLOGY

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

(2008) Dong Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Helical Structures of ESCRT-III Are Disassembled by VPS4

(2008) S. Lata et al.   SCIENCE

Structure and Disassembly of Filaments Formed by the ESCRT-III Subunit Vps24

(2008) Sara Ghazi-Tabatabai et al.   STRUCTURE

Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion

(2008) James W. Connell et al.   TRAFFIC