Article
Immunology
Chunying Xiao, Zhenlai Zhu, Chen Zhang, Jixin Gao, Yixin Luo, Hui Fang, Hongjiang Qiao, Wei Li, Gang Wang, Meng Fu
Summary: This study revealed that newly infiltrated inflammatory dermal Langerin(+) DCs play an essential role in the development of atopic dermatitis (AD) and the local production of TSLP, while TSLP further promotes the production of BM-derived i-Langerin(+) dDCs, which may contribute to the maintenance of AD inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Juan Manuel Leyva-Castillo, Mrinmoy Das, Emilie Artru, Juhan Yoon, Claire Galand, Raif S. Geha
Summary: The study found that IL-13 released by cutaneous MCs in response to mechanical skin injury inhibits the T(H)1 cell response to cutaneous antigen exposure in AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Monika Majewska-Szczepanik, Anna Strzepa, Katarzyna Marcinska, Marian Szczepanik
Summary: The contact hypersensitivity response (CHS) is a mouse model that mimics allergic contact dermatitis in humans. Experiments in mice showed that applying a protein antigen to the skin before inducing CHS effectively reduces the inflammatory response. Epicutaneous immunization also suppresses inflammatory response in various mouse models of autoimmune diseases. This suggests that EC immunization could be a therapeutic approach for T cell-mediated diseases in humans.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dermatology
Christoph H. Tripp, Hermann Voit, Angela An, Magdalena Seidl-Philipp, Johanna Krapf, Stephan Sigl, Nikolaus Romani, Barbara Del Frari, Patrizia Stoitzner
Summary: Dendritic cells are promising targets for immunotherapy of cancer, and laser-assisted epicutaneous immunization may be a valuable alternative to intradermal injection. However, the loading efficacy of DC needs to be further improved.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Yan-Wei Wu, Wan-Yu Wang, Yu-Hung Chen
Summary: This study demonstrates that a positively charged nanocomplex can drive the Th1 immune response and modulate dendritic cell differentiation. The surface charge and size of the nanocomplex were found to affect the immune response. Furthermore, vaccination with the positively charged nanocomplex was shown to increase specific antibody and memory T-cell responses.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Manami Toriyama, Defri Rizaldy, Motoki Nakamura, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J. Ishii
Summary: Atopic dermatitis is a common allergic skin disorder affecting up to 10% of adults in developed countries. This study reveals the presence of a previously unknown primary cilium-like structure in dendritic cells (DCs) and Langerhans cells (LCs), which becomes aberrantly expressed in AD patients. These findings suggest a potential role of the primary cilium in the pathogenesis of AD and may provide a new target for its treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Veterinary Sciences
Sang-Won Kim, Jung-Hyun Kim
Summary: This study aimed to establish an experimental model of canine atopic dermatitis (CAD) by repeated epicutaneous applications of mite antigens and to describe the entire process in detail. The results showed that the application of mite antigens resulted in elevated serum IgE levels, clinical atopic scores, high transepidermal water loss, and microbiome dysbiosis resembling spontaneous CAD.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kanako Nakayama, Hiroe Tetsu, Taku Nishijo, Takuo Yuki, Masaaki Miyazawa
Summary: Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. This study investigated the commonality of findings across haptens and mechanisms focused on dendritic cells (DCs) in AD. The results revealed that attenuated contact hypersensitivity (CHS) responses in AD may be hapten-independent and the tolerogenic phenotype of hapten-bearing DCs can contribute to reduced T-cell proliferation and CHS responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Plant Sciences
Jung-Eun Lee, Young-Whan Choi, Dong-Soon Im
Summary: The aim of this study was to identify an active phytochemical from Schisandra chinensis and evaluate its effects on AD-like symptoms. The results showed that alpha-cubebenoate, an active phytochemical in Schisandra chinensis, significantly improved AD-like symptoms by reducing skin hypertrophy and mast cell accumulation, as well as decreasing pro-inflammatory chemokine and cytokine levels. This study provides evidence for the therapeutic efficacy of alpha-cubebenoate in the treatment of AD symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Shujing Feng, Wengying Liu, Sisi Deng, Guoxuan Song, Jie Zhou, Zhengni Zheng, Zhiqiang Song
Summary: By alternately applying DNFB and DfE on BALB/c mice, AD-like models with typical clinical features and Th2-type immune responses can be induced, which could be valuable for studying the pathogenesis of AD and developing novel therapeutic agents for it.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Seunga Choi, Han-Gyu Choi, Yong Woo Back, Hye-Soo Park, Kang-In Lee, Sintayehu Kebede Gurmessa, Thuy An Pham, Hwa-Jung Kim
Summary: Studies have shown that the Rv1876 protein identified from Mtb culture filtrates can enhance DCs and Th1 cell immune responses, reducing bacterial load in the lungs when used in conjunction with the BCG vaccine.
Article
Pharmacology & Pharmacy
Yingjie Yu, Huan Wang, Beibei Guo, Bingkai Wang, Zhan Wan, Yunchang Zhang, Linhong Sun, Feng Yang
Summary: This study successfully prepared immunoliposomes that actively target Langerhans cells and delivered them via microneedles to activate cellular immune responses. The results showed that this method can significantly inhibit tumor growth and prolong survival.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Editorial Material
Medicine, General & Internal
Masutaka Furue, Mihoko Furue
Summary: The OX40L-OX40 axis plays a crucial role in the sustained activation and expansion of effector T cells, and has shown therapeutic potential in diseases like atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Olivier Lamiable, Maia Brewerton, Franca Ronchese
Summary: Skin functions as a protective barrier and is inhabited by various immune cells. This review focuses on the specialization of antigen-presenting cells in the skin and the role of IL-13 cytokine in immune responses. The impact of IL-13-blocking therapeutics on antigen-presenting cells in human skin is also discussed.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Microbiology
Sabrina Nicolo, Giorgio Mattiuz, Alberto Antonelli, Fabio Arena, Vincenzo Di Pilato, Tommaso Giani, Ilaria Baccani, Ann Maria Clemente, Giuseppe Castronovo, Michele Tanturli, Federico Cozzolino, Gian Maria Rossolini, Maria Gabriella Torcia
Summary: The study suggests that hypervirulent Klebsiella pneumoniae (Hv-Kp) strains can interfere with the function of dendritic cells (DCs) and the differentiation of T cells, possibly evading immune response and contributing to pathogen dissemination in immunocompetent hosts.
Letter
Dermatology
Lai-San Wong, Yu-Ta Yen, Shang-Hung Lin, Chih-Hung Lee
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Editorial Material
Dermatology
C. H. Lee
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Medicine, General & Internal
Yung-Wei Chang, Chih-Hung Lee, Han-Chi Tseng
Summary: This study investigated the association between clinical characteristics, classifications, and prognosis among different types of leukemia cutis (LC) in Taiwan. The study found a very poor prognosis for LC, with a high mortality rate during follow-up. There was no statistical significance among different types of LC in terms of survival curves.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Chien -Hui Hong, Shang -Hung Lin, Bjorn E. Clausen, Chih-Hung Lee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Education & Educational Research
Yung-Wei Chang, Chih-Hung Lee
BMC MEDICAL EDUCATION
(2020)
Article
Biochemistry & Molecular Biology
Shang-Hung Lin, Ji-Chen Ho, Sung-Chou Li, Yu-Wen Cheng, Yi-Chien Yang, Jia-Feng Chen, Chung-Yuan Hsu, Toshiaki Nakano, Feng-Sheng Wang, Ming-Yu Yang, Chih-Hung Lee, Chang-Chun Hsiao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Letter
Dermatology
C. -J. Su, C. -H. Lee
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Medicine, General & Internal
Ho-Chang Kuo, Chi-Hsiang Chu, Yu-Jih Su, Chih-Hung Lee
Article
Multidisciplinary Sciences
Ji-Chen Ho, Chih-Hung Lee, Chien-Hui Hong
Article
Dermatology
Musin Kelel, Ruey-Bing Yang, Tsen-Fang Tsai, Pi-Hui Liang, Fu-Yu Wu, Yu-Tien Huang, Ming-Fong Yang, Yu-Ping Hsiao, Li-Fang Wang, Chen-Fen Tu, Fu-Tong Liu, Yungling L. Lee
Summary: The study reveals that FUT8 remodeling of EGFR plays a critical role in the development of psoriasis phenotypes and is associated with disease severity. FUT8 gain of function promotes cell proliferation, while short hairpin FUT8 reduces proliferation and alters the cell cycle.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Kwei-Lan Liu, Wen-Chien Tsai, Hung-Pin Tu, Chih-Hung Lee
Article
Dermatology
Yi-Hsiang Yu, Pei-Lun Sun, Chih-Hung Lee, Chia-Jui Su, Han-Chi Tseng
Summary: Three rare cases of Pleosporales deep cutaneous infections were reported in a medical center in southern Taiwan. The patients, all elderly individuals living in rural tropical areas, presented with erythematous noduloplaques on their upper extremities. Treatment with oral itraconazole showed successful outcomes in two cases, while one case showed partial improvement but did not complete the treatment. Molecular tools were crucial for accurate species identification and successful treatment of DCFI.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Hsin-Wei Huang, Benny Wei-Yun Hsu, Chih-Hung Lee, Vincent S. Tseng
Summary: A lightweight skin cancer classification model based on deep learning methods was developed to assist in medical care. The model demonstrated high accuracy in diagnosing skin cancers and benign tumors, showing great potential for clinical diagnosis and early identification.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Guan-Yi He, Tai-Yi Hsu, Ching -Wen Chen, Feng-Jung Nien, Huan-Yuan Chen, Chia -Yu Chu, Li -Fang Wang
Summary: This study aimed to identify possible mediators responsible for diabetic pruritus. Higher levels of interleukin-4, interleukin-13, granulocyte-macrophage colony-stimulating factor, and C-X-C motif chemokine ligand 10 were observed in patients with pruritus. These mediators were positively correlated with the severity of itching, suggesting potential targets for novel antipruritic drugs.
ACTA DERMATO-VENEREOLOGICA
(2023)
Letter
Dermatology
Hao-Jui Weng, Yi-Hua Liao, Pei-Jung Lin, Jau-Shiuh Chen, Yu-Ping Cheng, Woan-Ruoh Lee, Shiou-Hwa Jee
DERMATOLOGICA SINICA
(2021)