Article
Multidisciplinary Sciences
Paula B. Donate, Kalil Alves de Lima, Raphael S. Peres, Fausto Almeida, Sandra Y. Fukada, Tarcilia A. Silva, Daniele C. Nascimento, Nerry T. Cecilio, Jhimmy Talbot, Rene D. Oliveira, Geraldo A. Passos, Jose Carlos Alves-Filho, Thiago M. Cunha, Paulo Louzada-Junior, Foo Y. Liew, Fernando Q. Cunha
Summary: Transcriptomic analysis revealed that microRNA-132 is induced specifically in Th17 cells in the presence of AhR agonist or CS-enriched medium. This induced miRNA132 acts as a proinflammatory mediator by promoting osteoclastogenesis through down-regulating COX2, exacerbating the development of RA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Jun-Way Chang, Yen-You Lin, Chun-Hao Tsai, Shan-Chi Liu, Xiu-Yuan He, Yi-Syuan Wu, Chien-Chung Huang, Chih-Hsin Tang
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune cell activation and chronic inflammation in the synovium, leading to joint destruction. Nesfatin-1, an adipokine, has been found to be increased in RA synovium and associated with proinflammatory cytokines.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Cell Biology
Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao
Summary: The translation discusses the role of osteoclasts in bone development and remodeling, as well as the significance of epigenetic regulation and microRNAs in gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shih-Yao Chen, Ting-Chien Tsai, Yuan-Tsung Li, Yun-Chiao Ding, Chung-Teng Wang, Jeng-Long Hsieh, Chao-Liang Wu, Po-Ting Wu, Ai-Li Shiau
Summary: This study demonstrates that IL-23 promotes osteoclastogenesis through transcriptional regulation of miR-223 in murine macrophages and mice with CIA. Furthermore, the study suggests that LSF, a selective inhibitor of STAT4, could be an ideal therapeutic agent for treating rheumatoid arthritis by reducing miR-223-mediated osteoclastogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Theo Wirth, Nathalie Balandraud, Laurent Boyer, Pierre Lafforgue, Thao Pham
Summary: PsA diagnosis and treatment is often delayed, resulting in joint damage and disability. Research has identified potential biomarkers to improve PsA diagnosis and prognosis, but further studies are needed to evaluate their performance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Meng Huang, Yan Wang, Zhenning Wang, Qiaozhen Qin, Heyang Zhang, Shuirong Liu, Jiantong Cui, Yu Zhang, Xiaoxia Jiang, Lulu Xu
Summary: The study shows that miR-134-5p inhibits osteoclast formation through targeting the Itgb1 gene and regulating the MAPK pathway, suggesting it could be a potential target for osteoporosis therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Hannah A. Blair
Summary: Secukinumab is an effective treatment for PsA across all key domains, with low rates of adverse effects and sustained long-term efficacy. It is a useful alternative to TNFi and other bDMARDs for adult patients with active PsA.
Article
Biochemistry & Molecular Biology
Santanu Kar, Ranjan Gupta, Rajesh Malhotra, Vijay Sharma, Kamran Farooque, Vijay Kumar, Sushmita Chakraborty, Dipendra Kumar Mitra
Summary: In patients with rheumatoid arthritis (RA), increased levels of IL-9 have been associated with tissue inflammation and abnormal osteoclastogenesis. IL-9 stimulation enhances osteoclast formation and modulates the expression of genes involved in metabolic pathways, as well as MMPs crucial for bone degradation. Blocking IL-9 pathways could be a potential immunotherapeutic target to prevent bone degradation in RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dermatology
Alice B. Gottlieb, Joseph F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that can lead to psoriatic arthritis, a heterogeneous musculoskeletal disease causing joint damage. Early detection and intervention by dermatologists is crucial in preventing permanent joint damage from psoriatic arthritis, which often manifests after skin symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Oliver FitzGerald, Alexis Ogdie, Vinod Chandran, Laura C. Coates, Arthur Kavanaugh, William Tillett, Ying Ying Leung, Maarten deWit, Jose U. Scher, Philip J. Mease
Summary: Psoriatic arthritis (PsA) is a complex inflammatory disease related to psoriasis, presenting challenges in diagnosis and treatment. There are no diagnostic criteria or tests available, and disease heterogeneity may be explained by differences in genotype. New targeted therapies have shown promise in improving outcomes for PsA patients.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Review
Immunology
Eric Toussirot, Irene Gallais-Serezal, Francois Aubin
Summary: Psoriasis and psoriatic arthritis are immune-mediated diseases that affect the skin, joints or both. They involve complex pathophysiological mechanisms and increased inflammation. These conditions are also associated with a higher risk of cardiometabolic diseases, which are linked to systemic inflammation and can impact disease severity and treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Feng-Chih Shen, Shao-Wen Weng, Meng-Han Tsai, Yu-Jih Su, Sung-Chou Li, Shun-Jen Chang, Jung-Fu Chen, Yen-Hsiang Chang, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Ching-Yi Lin, Pei-Wen Wang
Summary: Mitochondrial haplogroups have a significant impact on the clinical characteristics of type 2 diabetes, with patients carrying the D4 haplogroup being less likely to require insulin treatment compared to those with non-D4 haplotypes. However, there is no significant association between insulin requirement and genetic variants in nuclear DNA. This highlights the role of mitochondria in the management of common metabolic diseases.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Shang-Hung Lin, Ji-Chen Ho, Sung-Chou Li, Yu-Wen Cheng, Chung-Yuan Hsu, Wen-Yi Chou, Chang-Chun Hsiao, Chih-Hung Lee
Summary: In psoriatic arthritis, TNF-alpha recruits osteoclast precursors by increasing MCP-1 production but does not directly activate osteoclastogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Dean Luo, Hsin-Ting Tsai, Tai-Jan Chiu, Shau-Hsuan Li, Ya-Ling Hsu, Li-Jen Su, Meng-Hsiu Tsai, Ching-Yi Lee, Chang-Chun Hsiao, Chang-Han Chen
Summary: Leptin plays an important role in regulating lipid metabolism in nasopharyngeal carcinoma cells and could be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Chih-Ho Chen, Rajendra Prasad Janapatla, Lin-Hui Su, Hsin-Chieh Li, Kuang-Che Kuo, Chun-Chih Chien, Chang-Chun Hsiao, Cheng-Hsun Chiu
Summary: The multi-center clinical microbiological study in Taiwan aimed to evaluate the impact of childhood PCV13 immunization on pneumococcal disease, and the magnitude of serotype replacement in invasive and non-invasive pneumococcal disease among all age groups. The study found that childhood PCV13 immunization exerted an indirect protection to vaccine serotype clinically defined non-bacteremic pneumococcal pneumonia among adults, especially those between 50 and 64 years of age. Emerging non-PCV13 serotypes mainly caused non-invasive mucosal disease among children.
JOURNAL OF INFECTION
(2022)
Review
Cell Biology
Yung-Che Chen, Yu-Ping Chang, Kuo-Tung Huang, Po-Yuan Hsu, Chang-Chun Hsiao, Meng-Chih Lin
Summary: ACO is characterized by persistent airflow limitation and features of both asthma and COPD, associated with higher frequency and severity of exacerbations, faster lung function decline, and higher healthcare cost. Systemic inflammation in COPD and asthma is driven by Th1 and Th2 immune responses, with potential contributions to airway remodeling in ACO.
Article
Cell Biology
Yu-Jih Su, Fu-An Li, Jim Jinn-Chyuan Sheu, Sung-Chou Li, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Huan-Yuan Chen, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Pei-Wen Wang
Summary: In this study, the lupus murine model focused on the TLR7 pathway was activated through the MDA5 signaling pathway in splenic B cells, which plays a crucial role in the detection of viral infections and autoimmunity. Further investigation on MDA5 agonist/antagonist RNAs and detailed molecular interactions within B cells is warranted for lupus therapy.
Article
Biochemistry & Molecular Biology
Toshiaki Nakano, Chao-Long Chen, I-Hsuan Chen, Hui-Peng Tseng, Kuei-Chen Chiang, Chia-Yun Lai, Li-Wen Hsu, Shigeru Goto, Chih-Che Lin, Yu-Fan Cheng
Summary: Accumulating evidence suggests the involvement of tumor-derived exosomes in HCC development and recurrence. The study explores the impact of miR-4669 overexpression on HCC and its clinical value in predicting treatment response and HCC recurrence. Overexpression of miR-4669 enhances migration ability, leads to sorafenib resistance, and generates an immunosuppressive tumor microenvironment. Exosomal miR-4669 has clinical value in predicting treatment response and assessing the risk of HCC recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Developmental
Liang-Jen Wang, Sung-Chou Li, Yuan-Ming Yeh, Sheng-Yu Lee, Ho-Chang Kuo, Chia-Yu Yang
Summary: This study used high-throughput sequencing to explore the dysbiosis of the gut mycobiome in children with ADHD. The results showed that ADHD patients had abnormal fungal community composition and increased abundance of Candida, especially Candida albicans. The in vitro cell assay also demonstrated that C. albicans secretions enhanced intestinal permeability.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Te-Yao Hsu, Hsin-Hsin Cheng, Kuo-Chung Lan, Hsuan-Ning Hung, Yun-Ju Lai, Chih-Chang Tsai, Wen-Lang Fan, Sung-Chou Li
Summary: Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality, and early prediction of PTB is crucial for providing timely medical intervention. This study identified four protein biomarkers in amniotic fluid that were negatively correlated with neonatal weight and gestational age, and developed a prediction model with high accuracy for PTB.
SCIENTIFIC REPORTS
(2023)
Correction
Multidisciplinary Sciences
Te-Yao Hsu, Hsin-Hsin Cheng, Kuo-Chung Lan, Hsuan-Ning Hung, Yun-Ju Lai, Chih-Chang Tsai, Wen-Lang Fan, Sung-Chou Li
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Chih-Hsiang Lin, Sung-Chou Li, Ming-Hong Lin, Chen-Jui Ho, Yan-Ting Lu, Yuyu Lin, Pei-Hsien Lin, Kuo-Wang Tsai, Meng-Han Tsai
Summary: This study found that the methylation level of S100A6 gene was decreased in patients with autoimmune encephalitis (AE), and S100A6 promoted the infiltration of B lymphocytes across the blood-brain barrier. S100A6 antibodies could counteract the effect of S100A6, which may be a potential treatment target for AE.
BRAIN AND BEHAVIOR
(2023)
Article
Pediatrics
Sheng-Yu Lee, Sung-Chou Li, Chia-Yu Yang, Ho-Chang Kuo, Wen-Jiun Chou, Liang-Jen Wang
Summary: This study investigated the role of gut leakage biomarkers in the susceptibility of ADHD. The results showed that DEFA1 levels were significantly lower in ADHD group compared to the healthy control group. There was no significant difference in serum levels of zonulin and occludin. DEFA1 levels were negatively correlated with inattention scores, while occludin levels were positively correlated with detectability subtest scores. This study provides new insights into the relationship between gut leakage markers and cognition, advancing research on the pathophysiology of ADHD.
Article
Microbiology
Chih-Ming Tsai, Chun-Hsien Chen, Wei-Hung Cheng, Foekje F. Stelma, Sung-Chou Li, Wei-Chen Lin
Summary: This study investigated the effects of bacteria on A. castellanii by exposing them to different culture conditions. It was found that both bacteria and the culture medium had significant effects on the amino acid composition of A. castellanii. After long-term exposure, A. castellanii achieved amino acid homeostasis by downregulating the biosynthesis of several amino acids.
Article
Cell Biology
Yung-Che Chen, Po-Yuan Hsu, Mao-Chang Su, Yung-Lung Chen, Ya-Ting Chang, Chien-Hung Chin, I. -Chun Lin, Yu-Mu Chen, Ting-Ya Wang, Yong-Yong Lin, Chiu-Ping Lee, Meng-Chih Lin, Chang-Chun Hsiao
Summary: This study aimed to explore the role of a novel long non-coding RNA FKSG29 in the development of endothelial dysfunction induced by intermittent hypoxia with re-oxygenation in obstructive sleep apnea (OSA). The results showed that knockdown of FKSG29 could reverse the damage caused by intermittent hypoxia with re-oxygenation, and its protective effects were abolished by knockdown of miR-23a-3p.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yung-Che Chen, I-Chun Lin, Mao-Chang Su, Po-Yuan Hsu, Chang-Chun Hsiao, Te-Yao Hsu, Chia-Wei Liou, Yu-Mu Chen, Chien-Hung Chin, Ting-Ya Wang, Jen-Chieh Chang, Yong-Yong Lin, Chiu-Ping Lee, Meng-Chih Lin
Summary: This study found that autophagy dysfunction in obstructive sleep apnea (OSA) patients is associated with epigenetic regulation. Differences in protein/gene expressions and DNA methylation levels of autophagy-related genes (ATG) were observed in blood leukocytes between OSA patients and subjects with primary snoring (PS). The impaired autophagy activity in OSA patients was regulated by aberrant DNA methylation, correlated with clinical phenotypes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)