An integrated network pharmacology and cell metabolomics approach to reveal the role of rhein, a novel PPARα agonist, against renal fibrosis by activating the PPARα–CPT1A axis

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

(2021) Verónica Miguel et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia

(2021) Azadeh Harzandi et al.   iScience

A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis

(2021) Kaihui Zhang et al.   PHYTOMEDICINE

Functional Metabolomics Reveal the Role of AHR/GPR35 Mediated Kynurenic acid Gradient Sensing in Chemotherapy-induced Intestinal Damage

(2020) Di Wang et al.   Acta Pharmaceutica Sinica B

Comparative Toxicogenomics Database (CTD): update 2021

(2020) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Network pharmacology combined with metabolomics approach to investigate the protective role and detoxification mechanism of Yunnan Baiyao formulation

(2020) Jun-ling Ren et al.   PHYTOMEDICINE

The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia reperfusion injury

(2020) Angelique ML Scantlebery et al.   JOURNAL OF PATHOLOGY

ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis

(2019) Tzu-Ming Jao et al.   KIDNEY INTERNATIONAL

From single drug targets to synergistic network pharmacology in ischemic stroke

(2019) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

(2018) Pamela A. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OMIM.org: leveraging knowledge across phenotype–gene relationships

(2018) Joanna S Amberger et al.   NUCLEIC ACIDS RESEARCH

Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor

(2017) Norihiko Sakai et al.   KIDNEY INTERNATIONAL

The link between phenotype and fatty acid metabolism in advanced chronic kidney disease

(2017) Dan-Qian Chen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The potential of natural products for targeting PPAR α

(2017) Daniela Rigano et al.   Acta Pharmaceutica Sinica B

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression

(2016) Hua Chen et al.   Redox Biology

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue

(2012) Xiaoyan Sheng et al.   International Journal of Biological Sciences

The peroxisome proliferator-activated receptor-α agonist, BAY PP1, attenuates renal fibrosis in rats

(2011) Peter Boor et al.   KIDNEY INTERNATIONAL

Rhein Improves Renal Lesion and Ameliorates Dyslipidemia in db/db Mice with Diabetic Nephropathy

(2009) Qing Gao et al.   PLANTA MEDICA