Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation

Dual‐Specificity Phosphatase 26 Protects Against Cardiac Hypertrophy Through TAK1

(2021) Jing Zhao et al.   Journal of the American Heart Association

Myocardial Angiotensin Metabolism in End-Stage Heart Failure

(2021) Noemi Pavo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2021) Theresa A McDonagh et al.   EUROPEAN HEART JOURNAL

Curcumin analogue C66 attenuates obesity-induced myocardial injury by inhibiting JNK-mediated inflammation

(2021) Lin Ye et al.   BIOMEDICINE & PHARMACOTHERAPY

Crosstalk between the renin-angiotensin system and the endoplasmic reticulum stress in the cardiovascular system: Lessons learned so far

(2021) Vinicius Sepúlveda-Fragoso et al.   LIFE SCIENCES

Celastrol Attenuates Angiotensin II–Induced Cardiac Remodeling by Targeting STAT3

(2020) Shiju Ye et al.   CIRCULATION RESEARCH

MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

(2020) Yi Wang et al.   Nature Communications

FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway

(2020) Xuejun Hui et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of inflammatory chemokines in hypertension

(2020) Tomasz P. Mikolajczyk et al.   PHARMACOLOGY & THERAPEUTICS

The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation

(2019) Xin Xie et al.   Science Advances

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

(2019) Lauren B. Arendse et al.   PHARMACOLOGICAL REVIEWS

Angiotensin II receptor blocker LCZ696 attenuates cardiac remodeling through the inhibition of the ERK signaling pathway in mice with pregnancy-associated cardiomyopathy

(2019) Yi Wang et al.   Cell and Bioscience

Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway

(2019) Hai-han Liao et al.   Oxidative Medicine and Cellular Longevity

Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination

(2018) Depeng Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway

(2016) Chang-Yi Li et al.   BASIC RESEARCH IN CARDIOLOGY

MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

(2016) Jibo Han et al.   BASIC RESEARCH IN CARDIOLOGY

The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease

(2016) Christa L. Blenck et al.   CIRCULATION RESEARCH

Mnk1 (Mitogen-Activated Protein Kinase–Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in MiceNovelty and Significance

(2016) Yuan Yuan et al.   HYPERTENSION

Olmesartan ameliorates pressure overload-induced cardiac remodeling through inhibition of TAK1/p38 signaling in mice

(2016) Lianpin Wu et al.   LIFE SCIENCES

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

(2016) Yan-Xiao Ji et al.   Nature Communications

Ornamental Exterior versus Therapeutic Interior of Madagascar Periwinkle (Catharanthus roseus): The Two Faces of a Versatile Herb

(2015) Naghmeh Nejat et al.   TheScientificWorldJOURNAL

TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB and Bnip3 Pathways

(2015) Lei Li et al.   Scientific Reports

Ornamental Exterior versus Therapeutic Interior of Madagascar Periwinkle (Catharanthus roseus): The Two Faces of a Versatile Herb

(2015) Naghmeh Nejat et al.   Scientific World Journal

The Global Health and Economic Burden of Hospitalizations for Heart Failure

(2014) Andrew P. Ambrosy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives

(2014) Sabzali Javadov et al.   PHARMACOLOGY & THERAPEUTICS

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

(2011) Norimichi Koitabashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor Suppressor A20 Protects Against Cardiac Hypertrophy and Fibrosis by Blocking Transforming Growth Factor-β–Activated Kinase 1–Dependent Signaling

(2010) He Huang et al.   HYPERTENSION

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

(2010) Rita Moreno et al.   NUCLEIC ACIDS RESEARCH

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Role of the renin–angiotensin system in vascular inflammation

(2008) Chiara Marchesi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES