Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1

(2022) Lanqing Li et al.   BIOFACTORS

Tenascin‐C regulates migration of SOX10 tendon stem cells via integrin‐α9 for promoting patellar tendon remodeling

(2021) Kang Xu et al.   BIOFACTORS

Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo

(2021) Chunli Wang et al.   CELL CALCIUM

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

(2020) Robin Schwarzer et al.   CURRENT OPINION IN CELL BIOLOGY

Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies

(2020) Yu-Chin Liu et al.   Cells

Multiple roles of caspase‐8 in cell death, inflammation, and innate immunity

(2020) Pontus Orning et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting Lipid Metabolism in Liver Cancer

(2020) Malak Alannan et al.   BIOCHEMISTRY

HBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3‐mediated m6A modification of HIF‐1α

(2020) Nanmu Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis

(2020) Zhenqiang Sun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interconnection between Metabolism and Cell Cycle in Cancer

(2019) Philippe Icard et al.   TRENDS IN BIOCHEMICAL SCIENCES

Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways

(2019) Liu Li et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Bakuchiol suppresses oestrogen/testosterone-induced Benign Prostatic Hyperplasia development through up-regulation of epithelial estrogen receptor β and down-regulation of stromal aromatase

(2019) Lin Miao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of Bakuchiol on chondrocyte proliferation via the PI3K‐Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects

(2019) Kang Xu et al.   CELL PROLIFERATION

Targeting PI3K/Akt/mTOR pathway identifies differential expression and functional role of IL-8 in liver cancer stem cell enrichment

(2019) Deniz Cansen Kahraman et al.   MOLECULAR CANCER THERAPEUTICS

Histone lactylation links metabolism and gene regulation

(2019) Luke T. Izzo et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Apoptosis signaling and BCL-2 pathways provide opportunities for novel targeted therapeutic strategies in hematologic malignances

(2018) Huanling Wu et al.   BLOOD REVIEWS

Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway

(2018) Jinghui Sun et al.   CANCER LETTERS

Bcl-2 inhibitors as anti-cancer therapeutics: The impact of and on calcium signaling

(2018) Tamara Vervloessem et al.   CELL CALCIUM

Demethylzeylasteral (ZST93) inhibits cell growth and enhances cell chemosensitivity to gemcitabine in human pancreatic cancer cells via apoptotic and autophagic pathways

(2018) Feng Wang et al.   INTERNATIONAL JOURNAL OF CANCER

The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway

(2018) Ketao Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

ATR/CHK1 inhibitors and cancer therapy

(2018) Zhaojun Qiu et al.   RADIOTHERAPY AND ONCOLOGY

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer

(2018) Xing-Yu Zhong et al.   Cell Reports

Drug Resistance Driven by Cancer Stem Cells and Their Niche

(2017) Marta Prieto-Vila et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells

(2017) Yuzu Zhao et al.   Cell Death & Disease

Biomechanical profile of cancer stem-like cells derived from MHCC97H cell lines

(2016) Jinghui Sun et al.   JOURNAL OF BIOMECHANICS

Tigecycline Inhibits Glioma Growth by Regulating miRNA-199b-5p-HES1-AKT Pathway

(2016) R. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibitory effects of Hedyotis diffusa Willd. on colorectal cancer stem cells

(2016) GUODONG SUN et al.   Oncology Letters

Over-expression of TRIM37 promotes cell migration and metastasis in hepatocellular carcinoma by activating Wnt/β-catenin signaling

(2015) Jianxin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells

(2015) Narumol Bhummaphan et al.   Evidence-based Complementary and Alternative Medicine

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

(2015) Dingzhi Wang et al.   GASTROENTEROLOGY

Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1

(2015) Fan Xuan et al.   NEURO-ONCOLOGY

Lactate Dehydrogenase Is an Important Prognostic Indicator for Hepatocellular Carcinoma after Partial Hepatectomy

(2015) Jing-Ping Zhang et al.   Translational Oncology

The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management

(2014) Luca Faloppi et al.   BMC CANCER

Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: Implications for cell migration

(2014) Daniel E Conway et al.   Cell Adhesion & Migration

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

(2012) Shi L. Sheng et al.   FEBS Journal

Prediction of Posthepatectomy Recurrence of Hepatocellular Carcinoma by Circulating Cancer Stem Cells

(2011) Sheung Tat Fan et al.   ANNALS OF SURGERY

CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma

(2011) Lian Shu Piao et al.   CANCER LETTERS

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

CD13: Waving the flag for a novel cancer stem cell target

(2011) Bruno Christ et al.   HEPATOLOGY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety

(2011) Jun Bao et al.   RHEUMATOLOGY INTERNATIONAL

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

(2008) Zhen Fan Yang et al.   CANCER CELL